2013 Polyamines Gordon Research Conference and Gordon Research Seminar

2013年多胺戈登研究会议暨戈登研究研讨会

• 批准号: 8528010
• 负责人: John L. Cleveland
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-17 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528010
• 关键词: Academia; Aging; Applications Grants; Asia; Autoimmune Diseases; Award; Bacteria; Basic Science; Biological Models; Biology; Cardiovascular Diseases; Cell physiology; Clinical Oncology; Clinical Trials; Collaborations; Communicable Diseases; Communities; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Environment; Epigenetic Process; Europe; Fostering; Funding; Genetic Transcription; Goals; Homeostasis; Human; Infusion procedures; International; Ion Channel; Ischemia; Life; Location; Malignant Neoplasms; Messenger RNA; Metabolic Diseases; Metabolism; MicroRNAs; Neurodegenerative Disorders; Obesity; Organism; Parasitic infection; Pathway interactions; Pharmacologic Substance; Plants; Play; Polyamines; Postdoctoral Fellow; Prevention; Protozoa; Regulation; Request for Proposals; Research; Research Personnel; Resort; Role; Running; Scientist; Series; Structural Biologist; Students; Therapeutic; Therapeutic Agents; Translational Research; Translations; Travel; Vertebrates; Work; Yeasts; analog; data exchange; drug development; experience; forging; graduate student; human disease; meetings; multidisciplinary; next generation; notch protein; pathogen; polycation; posters; protein degradation; public health relevance; small molecule; success; symposium; tumorigenesis

DESCRIPTION (provided by applicant): The Polyamines Gordon Research Conference (GRC) has continuously run since 1975, where it provides a multidisciplinary forum that brings together top polyamine researchers as well as young and established investigators new to the field. The 2013 Polyamines GRC will be held at Waterville Valley Resort in Waterville Valley, NH, from June 16-21, 2013, and it will be focused on the regulation and role of polyamine pathways in cell physiology, development and human disease, and on the use and development of small molecules targeting polyamine metabolism as therapeutic agents in cancer, infectious disease and metabolic disorders. The GRC is unanimously regarded as the pre-eminent venue for the presentation of the very best in polyamine research. Polyamines are small, essential polycations found in all forms of life, yet their regulation varies widely among species and polyamine homeostasis is disabled in several pathological states. In particular, polyamines play unique roles in human pathogens and polyamine metabolism is markedly altered in ischemia, cardiovascular disease, obesity, diabetes and cancer, and in autoimmune and neurodegenerative disorders. Thus, the GRC brings together top-notch researchers who study polyamines in several organisms (vertebrates, yeast, plants, protozoa and bacteria) with those assessing therapeutic applications. This collage of scientific disciplines is unique amongst GRCs and creates a remarkably stimulating environment, with experts from many disciplines, including biologists, chemists, structural biologists and clinicians, and investigators from both academia and the biotech and pharmaceutical sectors. The 2013 Polyamines GRC will feature presentations from scientists at the forefront of basic and translational polyamine research, with an emphasis on the role of polyamines in tumorigenesis and metabolic and infectious diseases. The meeting will include presentations on roles of polyamines in basic cellular processes (e.g., epigenetics, transcription, translation, ion channel function), in development and disease, the normal and aberrant control of polyamine homeostasis and transport, polyamine- targeted drug development and clinical oncology and infectious disease trials. Presentations by invited speakers will be 30 minutes, followed by 10-minute discussion period. Sessions will also include short talks by students and postdoctoral fellows whose work is chosen from poster presentations. There will be two poster sessions during the meeting. To foster participation of young scientists, the 2013 GRC is held in conjunction with the 4th Polyamines Gordon Research Seminar (GRS). The GRS provides graduate students and fellows with a constructive venue that fosters the exchange of data in the absence of all but a few senior colleagues. The GRS has made the GRC a richer, more constructive experience, as it promotes the participation of young scientists during the main conference. The interactions between GRS and GRC conferees will facilitate the sharing of new research ideas, toolsets and model systems and will forge new collaborations that will to drive the field forward.

描述（由申请人提供）：自1975年以来，多胺戈登研究会议（GRC）一直在不断运行，在那里提供了一个多学科论坛，该论坛汇集了最高的多胺研究人员以及年轻的和既新手的研究人员。 2013年多胺GRC将于2013年6月16日至21日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行，它将集中在多胺途径在细胞生理学，发育和人类疾病中的调节和作用，以及针对靶向多胺代谢的小分子在癌症中疾病的小分子的使用和开发。 GRC一致认为是出现在多胺研究中最好的杰出场所。多胺是在各种生命形式中发现的小，必不可少的多阳离子，但它们的调节在物种中差异很大，多胺稳态在几种病理状态下都是残疾的。特别是，多胺在人类病原体中起着独特的作用，多胺代谢在缺血，心血管疾病，肥胖，糖尿病和癌症以及自身免疫性和神经退行性疾病中明显改变。因此，GRC汇集了研究多胺在几种生物（脊椎动物，酵母，植物，原生动物和细菌）中研究多胺的一流研究人员，以及评估治疗应用的人。科学学科的这种拼贴在GRC中是独一无二的，创造了一个非常刺激的环境，来自许多学科的专家，包括生物学家，化学家，结构生物学家和临床医生，以及来自学术界，生物技术和制药领域的研究人员。 2013年多胺GRC将以科学家的介绍为基础和转化多胺研究的最前沿，重点是多胺在肿瘤发生以及代谢和传染病中的作用。会议将包括有关多胺在基本细胞过程中的作用（例如表观遗传学，转录，翻译，离子通道功能），发育和疾病，多胺稳态和运输，多胺靶向药物发育以及临床肿瘤学和感染性疾病试验的正常和异常控制。受邀演讲者的演讲将为30分钟，然后进行10分钟的讨论期。会议还将包括学生和博士后研究员的简短会谈，这些演讲是从海报演示中选择的。会议期间将有两个海报会议。为了培养年轻科学家的参与，2013 GRC与第四个多胺戈登研究研讨会（GRS）结合。 GRS为研究生和研究员提供了一个建设性的场所，该场所在没有几个高级同事的情况下促进了数据交换。 GRS使GRC成为更丰富，更具建设性的体验，因为它促进了年轻科学家在主要会议期间的参与。 GRS与GRC Conferees之间的相互作用将促进新的研究思想，工具集和模型系统的共享，并将建立新的合作，以推动该领域前进。