2019 Polyamines GRS/GRC

2019 多胺 GRS/GRC

• 批准号: 9750998
• 负责人: Keith T. Wilson
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750998
• 关键词: Academia; Aging; Amino Acids; Applications Grants; Area; Arginine; Asia; Authorization documentation; Bacterial Infections; Basic Science; Biological Models; Biology; Biotechnology; Budgets; Cancer Biology; Cell physiology; Chemopreventive Agent; Clinical; Clinical Trials; Collaborations; Communities; DL-alpha-Difluoromethylornithine; Development; Diabetes Mellitus; Digestive System Disorders; Discipline; Disease; Drosophila genus; Epigenetic Process; Europe; Fostering; Funding; Genetic Transcription; Goals; Host Defense; Hour; Human; Immune response; Immunology; Infection; Inflammation; Infusion procedures; International; Intervention; Ion Channel; Lead; Learning; Life; Link; Location; Malignant Neoplasms; Mammals; Metabolic Control; Metabolic Diseases; Metabolism; Names; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Neuroblastoma; North America; Organism; Outcome; Parasites; Parasitic infection; Participant; Pathway interactions; Pharmacologic Substance; Physicians; Plants; Play; Polyamines; Prevention; Prokaryotic Cells; Regulation; Request for Proposals; Research; Research Personnel; Role; Running; Scientist; South America; Students; Translational Research; Translations; Travel; United States National Institutes of Health; Vertebrates; Work; base; c new; carcinogenesis; career; career development; cost; data exchange; experience; graduate student; human disease; innovation; interest; meetings; member; microbiome; multidisciplinary; nervous system disorder; next generation; novel; pathogen; polycation; posters; programs; success; symposium; targeted treatment; translational impact; tumor

Project Summary. The Polyamines Gordon Research Conference (GRC) has run continuously since 1975, and provides a multidisciplinary forum that brings together leading polyamine researchers, as well as young and established investigators new to the field. The 2019 Polyamines GRC will be held at Waterville Valley Hotel in Waterville Valley, NH, from June 23-28, 2019. This GRC will have a broad focus on the role of polyamines in human diseases, with topic areas that include cancer biology, immunology/inflammation, host-pathogen interactions, digestive diseases, diabetes, neurologic disorders, and many new potential interventions. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino-acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2019 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. It will showcase key new links between arginine metabolism and polyamines, and other metabolic control pathways that can then lead to alterations in host defense against pathogens and tumors, immune responses leading to inflammation, carcinogenesis, metabolic disorders, neurologic diseases, aging, and the microbiome. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, and physician-scientists, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 26 named speakers, 25 are new since the last GRC and 18 have never spoken at the GRC; 9 are early career scientists. We will choose 6 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 41 GRC and 16 GRS registrations, and travel costs for 16 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to develop promising young scientists into contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 7th Polyamines GRS, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, promoting participation of young scientists during the main conference. Interactions between GRS and GRC conferees facilitate sharing of new ideas and create new partnerships that will drive the field forward.

项目摘要。 多胺戈登研究会议 (GRC) 自 1975 年以来一直持续举办，并提供了 多学科论坛汇聚了领先的多胺研究人员以及年轻和成熟的研究人员 新进入该领域的调查人员。 2019 年 Polyamines GRC 将于沃特维尔 Waterville Valley Hotel 举行 新罕布什尔州山谷，时间为 2019 年 6 月 23 日至 28 日。本次 GRC 将广泛关注多胺在人体中的作用 疾病，主题领域包括癌症生物学、免疫学/炎症、宿主-病原体相互作用、 消化系统疾病、糖尿病、神经系统疾病以及许多新的潜在干预措施。会议是 其独特之处在于它吸引了众多顶尖研究人员来评估多胺的控制和作用 涵盖广泛的模型系统（原核生物、寄生虫、果蝇、植物、脊椎动物和 哺乳动物）。多胺是一种由氨基酸衍生的小聚阳离子，存在于所有生命形式中，并且发挥着重要作用 在许多细胞过程中发挥作用，包括转录、翻译、复制、代谢、表观遗传控制、 和离子通道功能。 2019 年多胺 GRC 将重点关注癌症中的多胺途径 和其他疾病。它将展示精氨酸代谢和多胺之间的关键新联系，以及其他 代谢控制途径可以导致宿主对病原体和肿瘤的防御发生改变， 免疫反应导致炎症、致癌、代谢紊乱、神经系统疾病、衰老、 和微生物组。该计划拥有强大的基础研究人员、转化研究人员和临床研究人员。这个GRC 参加会议的有生物学家、化学家和医学科学家，其中包括来自学术界的研究人员， 生物技术和制药行业。科学学科的多样性在 GRC 中是独一无二的，高度 刺激，并将强调与上游和下游途径以及疾病相关的新发现 直到最近才与多胺生物学的改变联系起来。我们将把最新的研究、新的研究人员带到 领域和早期职业研究人员参加这个论坛。在 26 名指定演讲者中，有 25 名是自上次 GRC 以来新加入的 18 人从未在集选区发言； 9 人是职业生涯早期的科学家。我们将从以下人员中选出 6 位演讲者 戈登研究研讨会 (GRS) 和海报，将增加更多新演讲者。具体目标寻求 获得资金支持 41 个 GRC 和 16 个 GRS 注册，以及 16 个 GRC/GRS 参与者的差旅费。 长期目标是增强对多胺代谢和多胺代谢之间相互作用的了解。 人类疾病，并培养有前途的年轻科学家成为多胺的贡献成员 科学界。受邀演讲者的演讲时间为 25-30 分钟，并有 10 分钟的讨论。 GRC 将与第七届多胺 GRS 同期举行，为研究生和研究员提供 设有一个由学生经营的场所，促进数据和思想的交流。 GRS 使 GRC 变得更加富裕 经验，促进年轻科学家在主会议期间的参与。 GRS之间的相互作用 GRC 与会者促进新想法的分享并建立新的合作伙伴关系，从而推动该领域向前发展。