Clinical and Translational Science Institute

临床与转化科学研究所

• 批准号: 8282773
• 负责人: S. CLAIBORNE JOHNSTON
• 金额: $ 1899.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8282773
• 关键词: Academic Medical Centers; Acceleration; Accountability; Advocacy; Area; Basic Science; Biological Models; Biomedical Engineering; Businesses; California; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Community Practice; Consultations; Contracts; Data; Data Set; Development; Diagnostic tests; Distance Learning; Doctor of Medicine; Doctor of Philosophy; Engineering; Environment; Epidemiology; Faculty; Fostering; Funding; Goals; Health; Health Policy; Healthcare; Home environment; Hour; Improve Access; Industry; Informatics; Institutes; Institution; Institutional Review Boards; Interdisciplinary Study; Internships; Intervention; Knowledge; Leadership; Medical Records; Metric; Mission; Modeling; Multicenter Studies; Participant; Patients; Performance; Phase; Policies; Population; Principal Investigator; Public Health; Regulation; Research; Research Infrastructure; Research Personnel; Research Training; Rewards; San Francisco; Schools; Series; Services; Site; Students; Training; Training Programs; Training and Infrastructure; Translational Research; Trust; Universities; Work; base; catalyst; clinical application; cost effectiveness; design; evidence base; improved; innovation; meetings; multidisciplinary; programs; randomized trial; skills; success; tool; translational medicine; virtual

DESCRIPTION (provided by applicant): We established the UCSF Clinical and Translational Science Institute (CTSI) at the University of California, San Francisco (UCSF) in 2006 to accelerate the pace of research that improves the health of the public. The overall mission of CTSI has been to improve and transform clinical and translational research infrastructure and training at UCSF and our partner institutions. In the next funding period we aim to use the substantial knowledge, skills, and infrastructure that we have developed to further accelerate the pace of research at UCSF, to export our successes to other institutions, and to create initiatives aimed at improving the health of our own and other communities, through the following aims: SPECIFIC AIM 1: To enhance the highly successful activities of the UCSF CTSI, including the development of new initiatives in the areas of Training, Infrastructure/Services, and Advocacy/Culture Change: a) Training: to provide programs for students at all levels, across a spectrum of settings, and including all phases of the improvement of healthcare; b) Infrastructure/Services: to expand services and tools to clinical and translational investigators at UCSF, our partner institutions, and within the broader regional, national, and global communities; and, c) Advocacy/Culture Change: to nurture communication, encourage collaboration, foster innovation, and catalyze the successful conduct of clinical and translational research; to support a diverse faculty; to increase involvement of the community and the responsive of research to its needs; and change the academic culture to promote multidisciplinary, collaborative work. SPECIFIC AIM 2: To develop crosscutting initiatives using the knowledge, skills, and infrastructure developed by multiple CTSI programs in the first funding period to accelerate clinical and translational research and its impact on health, well beyond the institutions collaborating in the UCSF CTSI. New initiatives will: a) Bring together local public health and philanthropic groups to work with CTSI to improve the health of the San Francisco Bay Area community through a series of health improvement projects directed at high impact conditions; b) create a model system to accelerate the pace of clinical and translational research that includes streamlining regulation, developing participant recruitment services, providing research management, and bringing research services directly into community practices; and, c) improve the performance, transparency and accountability of research administration within and beyond CTSI by setting challenging goals and tracking performance metrics on public dashboards. These aims will be achieved by orchestration of activities occurring within and between our 10 programs, supported by a proven governance model, and with strong ties to institutional and community leadership. Our ultimate goal is to bring better health to more people more quickly.

描述（由申请人提供）：我们于 2006 年在加州大学旧金山分校 (UCSF) 建立了 UCSF 临床与转化科学研究所 (CTSI)，以加快改善公众健康的研究步伐。 CTSI 的总体使命是改善和改造 UCSF 及其合作机构的临床和转化研究基础设施和培训。在下一个资助期间，我们的目标是利用我们开发的大量知识、技能和基础设施来进一步加快加州大学旧金山分校的研究步伐，将我们的成功成果输出到其他机构，并制定旨在改善我们人类健康的举措。自己和其他社区，通过以下目标： 具体目标 1：加强 UCSF CTSI 非常成功的活动，包括在培训、基础设施/服务和宣传/文化变革领域制定新举措： a) 培训：为各级学生提供计划，跨越一系列环境，包括改善医疗保健的所有阶段； b) 基础设施/服务：将服务和工具扩展到加州大学旧金山分校、我们的合作机构以及更广泛的区域、国家和全球社区内的临床和转化研究人员； c) 倡导/文化变革：培养沟通、鼓励合作、促进创新并促进临床和转化研究的成功进行；支持多元化的教师队伍；增加社区的参与以及研究对其需求的响应；改变学术文化以促进多学科的协作工作。 具体目标 2：利用多个 CTSI 项目在第一个资助期内开发的知识、技能和基础设施来制定跨领域举措，以加速临床和转化研究及其对健康的影响，远远超出 UCSF CTSI 合作机构的范围。新举措将： a) 汇集当地公共卫生和慈善团体与 CTSI 合作，通过一系列针对高影响条件的健康改善项目来改善旧金山湾区社区的健康； b) 创建一个模型系统，加快临床和转化研究的步伐，包括简化监管、开发参与者招募服务、提供研究管理以及将研究服务直接纳入社区实践； c) 通过设定具有挑战性的目标并在公共仪表板上跟踪绩效指标，提高 CTSI 内部和外部研究管理的绩效、透明度和问责制。 这些目标将通过协调我们 10 个项目内部和之间发生的活动来实现，并得到经过验证的治理模型的支持，并与机构和社区领导层保持紧密联系。我们的最终目标是更快地为更多人带来更好的健康。