Patient and Population Sciences

患者和人口科学

基本信息

批准号：
8300285
负责人：
MAX S. WICHA
金额：
$ 22.91万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8300285
关键词：
Alcohol consumption Back Basic Science Behavioral Behavioral Risk Factor Surveillance System Biopsy Blood Blood specimen Breast Budgets Cancer Center Cancer Center Support Grant Cancer Control Cancer Patient Cancer Research Project Cataloging Catalogs Charge Clinic Clinical Clinical Data Clinical Research Collaborations Common Data Element Community Health Confidentiality of Patient Information Consent DNA Data Data Element Databases Development Diagnosis Diagnostic Dictionary Diet Discipline Electronics Enrollment Environment Epidemiologic Studies Epidemiology Evaluation Family Feedback Fees Funding Funding Agency Goals Grant Guidelines Health Health Communication Health system Histology Indium Individual Information Management Institutes Institution Institutional Review Boards Internet Label Link Malignant Neoplasms Medical Medical History Medical Records Metric Michigan Mission Molecular Monitor Paper Participant Patient Representative Patients Phase Physical activity Pilot Projects Population Population Sciences Predisposition Procedures Process Production Protocols documentation Public Health Quality of life Questionnaires Recording of previous events Recruitment Activity Reproductive History Research Research Infrastructure Research Personnel Resource Sharing Resources Risk Risk Factors Sampling Screening for cancer Services Signs and Symptoms Smoking Smoking History Source Specialist Specimen Staging Strategic Planning Surveys Technology Testing Training Treatment outcome Tube Universities University of Michigan Comprehensive Cancer Center Weight Woman Women&apos s Group Work Writing base biobank cancer Biomedical Informatics Grid cancer prevention cancer risk cost demographics empowered innovation instrument interest meetings member multidisciplinary neoplasm registry operation patient population peer population based prognostic programs prototype repository research study sample collection

项目摘要

The University of Michigan Comprehensive Cancer Center (UMCCC) is one of the nation's premiere multidisciplinary cancer research programs, with a long Institutional tradition of excellence in patient and population-based research. The Patient and Population Core is a new cancer center core resource that has been developed as a result of UMCCC's strategic planning to meet key needs of cancer center researchers identified through a strategic planning process. Programs in cancer prevention and control, clinical research, and basic science all require enhanced access to annotated patient and population data with accompanying DNA samples In order to continue the cancer center's mission and commitment to achieve innovative research in personalized cancer prevention, diagnosis and treatment. The Patient and Population Core is a resource that collects, catalogs, and stores DNA samples together with highly annotated, linked clinical and epidemiologic Information from cancer patients and representative controls without cancer. Building upon an already established cancer center infrastructure and health-system wide institutional commitment to biobanking, the Patient and Population Core takes advantage of the combined resources of the Michigan Institute for Clinical Health Research (MICHR) Biorepository and the Michigan Clinical Research Unit (MCRU) to provide cancer-specific resources to members of the cancer center, This resource will facilitate environmental, susceptibility, prognostic, and mechanistic studies to be conducted by researchers from various disciplines within the cancer center, as well as provide opportunities for pilot studies and resources for successful grant submissions for translational and molecular epidemiologic research studies, by linking specimen data with questionnaire and medical record data. The overall goal of this core is to further empower our investigators, promote resource sharing, and maximize the value of data and DNA sample collection for research participants, investigators, UMCCC members, and our funding agencies. Since its inception in April 2010, DNA samples and data from 3,910 patients have been established within the Patient and Population Core repository, and 7 cancer center members have accessed DNA samples and data. CCSG funding comprises 36% of the proposed core budget, with the remaining support from charge-backs at rates determined by institution-wide metrics and other institutional support.

密歇根大学综合癌症中心 (UMCCC) 是美国首屈一指的多学科癌症研究项目之一，在以患者和人群为基础的研究方面拥有悠久的卓越机构传统。患者和人口核心是新的癌症中心核心资源，是 UMCCC 战略规划的结果，旨在满足通过战略规划流程确定的癌症中心研究人员的关键需求。癌症预防和控制、临床研究和基础科学项目都需要更好地获取带有 DNA 样本的带注释的患者和人群数据，以便继续履行癌症中心的使命和承诺，实现个性化癌症预防、诊断和治疗方面的创新研究。患者和人群核心是一种收集、编目和存储 DNA 样本的资源，以及来自癌症患者和非癌症代表性对照的高度注释、关联的临床和流行病学信息。患者和人群核心建立在已建立的癌症中心基础设施和卫生系统范围内对生物样本库的机构承诺的基础上，利用密歇根临床健康研究所 (MICHR) 生物样本库和密歇根临床研究单位 (MCRU) 的综合资源为癌症中心成员提供癌症特异性资源，该资源将促进癌症中心内不同学科的研究人员进行环境、易感性、预后和机制研究，并为试点研究和通过将样本数据与问卷和病历数据联系起来，为转化和分子流行病学研究成功提交拨款的资源。该核心的总体目标是进一步增强研究人员的能力，促进资源共享，并最大限度地提高研究参与者、研究人员、UMCCC 成员和资助机构的数据和 DNA 样本收集的价值。自 2010 年 4 月启动以来，患者和人群核心存储库中已建立了 3,910 名患者的 DNA 样本和数据，并且 7 名癌症中心成员已经访问了 DNA 样本和数据。 CCSG 资金占拟议核心预算的 36%，其余支持来自按机构范围指标和其他机构支持确定的费率退款。