Identifying the neurobehavioral signature of individuals with AUD and comorbid PTSD

识别患有 AUD 和共病 PTSD 的个体的神经行为特征

基本信息

批准号：
10019441
负责人：
Amber Jarnecke
金额：
$ 20.35万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10019441
关键词：
Address Alcohol abuse Alcohol consumption Alcoholism Alcohols Amber Amygdaloid structure Area Back Basic Science Behavior Behavior Therapy Behavioral Behavioral Mechanisms Behavioral Research Biomedical Research Cause of Death Clinical Clinical Research Cognition Complex Corpus striatum structure Data Data Analyses Decision Making Development Disease Emotional Empirical Research Employment Ensure Foundations Functional Magnetic Resonance Imaging Future Goals Grant HIV risk Habits Human Impairment Individual Institutes Intervention Investigation Knowledge Laboratories Legal Literature Magnetic Resonance Maintenance Medical Medical Economics Mental Depression Mental Health Mentored Patient-Oriented Research Career Development Award Mentorship Methodology Mission Motivation Neurobiology Pathway interactions Perception Personality Play Post-Traumatic Stress Disorders Prefrontal Cortex Psychologist Public Health Relapse Research Research Design Research Personnel Research Project Grants Rest Rewards Risk Behaviors Scientist Series Sex Differences Sleep Solid South Carolina Statistical Data Interpretation Strategic Planning Symptoms Techniques Training Translating Treatment outcome United States Universities Ventral Striatum Withdrawal Writing alcohol comorbidity alcohol cue alcohol research alcohol use disorder base behavioral disinhibition behavioral phenotyping behavioral response career career development comorbidity cost craving design effective intervention effective therapy executive function experience high risk individual response interest negative affect neural circuit neurobehavioral neurobiological mechanism neuroimaging neuromechanism novel outcome forecast patient oriented research physical conditioning prevent programs psychosocial reduce symptoms relating to nervous system response responsible research conduct skills suicidal risk

项目摘要

The overall aim of the proposed K23 Mentored Patient-Oriented Research Career Development Award is to allow Dr. Amber Jarnecke to develop new knowledge and research skills in (1) alcohol use disorders (AUD) and co-occurring mental health conditions, in particular, posttraumatic stress disorder (PTSD); and (2) the application of neuroimaging and human laboratory paradigms to investigate AUD and PTSD. Research demonstrates that individuals with comorbid AUD and PTSD have a more severe clinical presentation; more psychosocial, legal, medical and economic problems; and poorer treatment outcomes as compared to individuals with either disorder alone. Despite the frequent co-occurrence and deleterious consequences associated with comorbid AUD and PTSD, research on effective treatments for this comorbidity is sparse, and empirical data is critically needed to inform the development of effective interventions. Investigation of the neural circuitry and behavioral responses underlying comorbid AUD and PTSD may help develop a more thorough understanding of this common comorbidity, and identify viable treatment targets for future interventions. The candidate is a clinical psychologist with a strong background in research design, statistical analysis, and behavioral interventions for AUD. Under the proposed K23 award, she aims to obtain new knowledge and research skills in order to advance toward her long-term career goal of becoming an independent investigator conducting patient-oriented research, able to translate findings from basic research into new treatments that target the underlying neurobiological mechanisms of AUD and comorbid conditions, such as PTSD. To that end, the candidate's immediate career goals under the proposed K23 are to: (1) develop a solid foundation in the neurobiology of AUD and PTSD; (2) obtain experience in advanced neuroimaging techniques and data analysis in order to better understand the AUD/PTSD neurobiological interface; (3) become proficient in the conduct of human laboratory paradigms; (4) continue training in the responsible conduct of research, and (5) enhance her scientific and grant writing skills. Under the mentorship of outstanding investigators (Drs. Sudie Back, Jane Joseph, and Kathleen Brady at the Medical University of South Carolina and Dr. Rajita Sinha at Yale University), the candidate will employ task-based functional magnetic resonance imaging (fMRI) to investigate the neurobehavioral responses of individuals with comorbid AUD and PTSD. The mentorship and training afforded by the proposed K23 award will significantly enhance the candidate's career development in the area of patient-oriented research focused on AUD and comorbid PTSD. The combination of outstanding mentorship, hands-on experience, didactics and formal coursework will provide a rich training experience and critical preliminary data to support future R-series applications. This K23 application is directly responsive to the mission of NIAAA and the strategic plan to understand, prevent, and treat AUD and co-occurring mental health conditions.

拟议的 K23 指导的以患者为导向的研究职业发展奖的总体目标是让 Amber Jarnecke 博士在 (1) 酒精使用障碍 (AUD) 方面发展新知识和研究技能以及同时发生的心理健康状况，特别是创伤后应激障碍（PTSD）；和（2）应用神经影像学和人类实验室范例来研究 AUD 和 PTSD。研究表明患有 AUD 和 PTSD 共病的个体具有更严重的临床表现；更多的社会心理、法律、医疗和经济问题；和较差的治疗结果相比单独患有任何一种疾病的人。尽管经常同时发生并产生有害后果与合并症 AUD 和 PTSD 相关，针对这种合并症的有效治疗方法的研究很少，并且迫切需要经验数据来为制定有效干预措施提供信息。调查 AUD 和 PTSD 共病背后的神经回路和行为反应可能有助于开发更多彻底了解这种常见的合并症，并确定未来可行的治疗目标干预措施。候选人是一位临床心理学家，在研究设计、统计方面拥有深厚的背景 AUD 的分析和行为干预。根据拟议的 K23 奖项，她的目标是获得新的知识和研究技能，以实现她成为一名独立研究者进行以患者为导向的研究，能够转化基础研究的结果针对 AUD 和合并症的潜在神经生物学机制的新疗法，例如创伤后应激障碍。为此，候选人在拟议的 K23 下的近期职业目标是：(1) 为 AUD 和 PTSD 的神经生物学奠定坚实的基础； (2) 获得先进经验神经影像技术和数据分析，以便更好地了解 AUD/PTSD 神经生物学界面; (3) 精通人类实验室范式的实施； (4)继续培训负责任地进行研究，(5) 提高她的科学和资助写作技能。在师徒的指导下杰出研究人员（美国医科大学的 Sudie Back、Jane Joseph 和 Kathleen Brady 博士）南卡罗来纳州和耶鲁大学的 Rajita Sinha 博士），候选人将采用基于任务的功能磁共振成像（fMRI）研究共病个体的神经行为反应澳元和创伤后应激障碍。拟议的 K23 奖项提供的指导和培训将显着增强候选人在以患者为中心的研究领域的职业发展，重点是 AUD 和共病创伤后应激障碍。杰出的指导、实践经验、教学法和正式课程的结合将提供丰富的培训经验和关键的初步数据，以支持未来的R系列应用。这个K23 应用程序直接响应 NIAAA 的使命以及理解、预防和预防的战略计划治疗 AUD 和同时发生的心理健康状况。