Cancer Cell Biology

癌细胞生物学

基本信息

批准号：
8719610
负责人：
MAX S. WICHA
金额：
$ 5万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8719610
关键词：
Advanced Malignant Neoplasm Antibodies Area Basal cell carcinoma Breast Cancer Biology Cancer Center Support Grant Cell Death Cellular biology Clinical Trials Colorectal Cancer Data Development Discipline Embryo Erinaceidae Funding Future Goals Grant Growth Human MMP14 gene MT2-MMP Maintenance Malignant Neoplasms Malignant neoplasm of ovary Matrix Metalloproteinases Mission Molecular Multiple Myeloma Neoplasm Metastasis Neoplasms Pancreas Pancreatic Adenocarcinoma Pathway interactions Peptide Hydrolases Phase Phase I Clinical Trials Process Publications Publishing Research Research Personnel Research Support Scientist Signal Pathway Soft Tissue Neoplasms Solid Neoplasm Staging Testing Therapeutic Tumor Biology Tumor Cell Invasion University of Michigan Comprehensive Cancer Center Work base cancer cell cancer prevention cancer stem cell cancer therapy cancer type chromatin remodeling docetaxel gamma secretase gemcitabine improved inhibitor/antagonist malignant breast neoplasm member neutralizing antibody novel preclinical study programs smoothened signaling pathway translational study treatment effect treatment strategy trial comparing tumor tumorigenesis

项目摘要

The Cancer Cell Biology (CCB) Program is comprised of 62 members from 23 departments. Since the past funding cycle the research base of the Cancer Cell Biology has nearly doubled from $15,046,494 to $22,406,120 total annual direct research support, of which $3,643,399 is from the NCI. Over this last grant period, there were 558 publications of Cancer Cell Biology Program members, of which 3.9% are intraprogrammatic and 24.2% are inter-programmatic . Members of the Cancer Cell Biology program are nationally recognized experts in a spectrum of disciplines unified by the goal of furthering our understanding of the process of oncogenesis at the cellular and molecular level, In order to develop new strategies for the treatment and prevention of cancer. Program investigators have advanced cancer biology in the areas of deregulated growth, proliferation, and cell death pathways: chromatin remodeling; cancer stem cells; embryonic signaling pathways; and tumor invasion programs. The bench-based research carried out by our program members has led to translational studies and clinical trials using novel, targeted approaches to cancer therapy which may afford significant advantages over currently available therapeutics.

癌细胞生物学 (CCB) 项目由来自 23 个部门的 62 名成员组成。自上一个资助周期以来，癌细胞生物学的研究基础几乎翻了一番，从每年的 15,046,494 美元增加到 22,406,120 美元，其中 3,643,399 美元来自 NCI。在上一个资助期内，癌细胞生物学计划成员发表了 558 篇出版物，其中 3.9% 为计划内出版物，24.2% 为计划间出版物。癌细胞生物学项目的成员是全国公认的多学科专家，其目标是加深我们对细胞和分子水平上肿瘤发生过程的理解，以便制定治疗和预防癌症的新策略。项目研究人员在生长、增殖和细胞死亡途径失调等领域拥有先进的癌症生物学：染色质重塑；癌症干细胞；胚胎信号通路；和肿瘤侵袭计划。我们的项目成员进行的基于实验室的研究已经导致使用新颖的、有针对性的癌症治疗方法进行转化研究和临床试验，这些方法可能比目前可用的治疗方法具有显着的优势。