COBRE in Lipidomics and Pathobiology

COBRE 在脂质组学和病理生物学中的应用

基本信息

批准号：
8514026
负责人：
Besim Ogretmen
金额：
$ 105.65万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-19 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8514026
关键词：
Achievement Address Animal Disease Models Animal Model Animals Antifungal Agents Area Atherosclerosis Biological Biological Markers Biology Biology of Aging Cancer Biology Cancer Center Cardiovascular Diseases Centers of Research Excellence Ceramidase Ceramides Collaborations Colon Carcinoma Communicable Diseases Communities Complex Core Facility Core Protein Cryptococcus Data Development Diabetes Mellitus Diagnostic Diet Discipline Disease Disease Progression Educational workshop Ensure Environment Enzyme Inhibitor Drugs Enzyme Inhibitors Enzymes Evaluation Extramural Activities Faculty Fatty Acids Functional disorder Funding Future Genes Glucosylceramides Goals Grant Growth Growth and Development function Head and Neck Cancer High Density Lipoproteins Human Immune response Individual Industry Infection Inflammation Inflammatory Bowel Diseases Inflammatory Response Institution Insulin Resistance Interdisciplinary Study International Ischemia Journals Knock-out Laboratories Lead Leadership Lipids Malignant Neoplasms Medical Mentors Metabolic Diseases Metabolism Minority Mixed Function Oxygenases Muscle function Mutation Nerve Degeneration Neuronal Injury Pathogenesis Pathway interactions Peer Review Phase Physiological Physiology Pilot Projects Positioning Attribute Prostate Proteins Publications Recruitment Activity Regulation Relative (related person)Research Research Personnel Resources Rheumatoid Arthritis Role Rotation SKI gene Schedule Science Seeds Serum Services Smooth Muscle South Carolina Sphingolipids Strategic Planning Subgroup Targeted Research Testing Therapeutic Therapeutic Agents Translational Research Translations Universities Ursidae Family Woman Work angiogenesis assay development base cerebrovascular dihydroceramide desaturase drug development drug discovery enzyme pathway galactosylgalactosylglucosylceramidase high throughput screening inhibitor/antagonist innovation leukodystrophy macrophage meetings new therapeutic target novel preclinical study programs public health relevance ranpirnase research and development response success symposium therapeutic development vasculogenesis

项目摘要

DESCRIPTION (provided by applicant): The emerging Center in Lipidomics and Pathobiology at the Medical University of South Carolina (MUSC) builds on substantial accomplishments during the first two phases of the COBRE. These include mentoring of 19 targeted junior faculty investigators, 14 of whom have achieved independent extramural funding, 193 publications in peer-review journals by the target faculty, participation by more than 25 MUSC research faculty in COBRE activities, and development and enhancement of highly successful, innovative scientific core facilities, including a unique core in Lipidomics, and emerging focused cores in animal pathobiology (focused on lipid-based animal models) and a protein core focused on lipid enzymes and targets. The COBRE has also been very successful in recruiting minorities (2) and women (10) as target faculty. The organizing hypothesis states that the universe of bioactive lipids and related metabolites constitutes a complex network of diverse pathways regulating key physiologic functions. In turn, dysfunctions in these pathways contribute to the pathobiology of specific diseases. Counterbalancing the biological significance of lipids are unique considerations that arise from the relative difficulties of studying lipids and lipid-interacting proteins. These necessitate the development of competent shared facilities and collaborative efforts to bring various disciplines and expertise to bear on specific problems. Therefore, the strategic focus of the next phase is to achieve the development of a stand-alone Center of Lipidomics and Pathobiology at MUSC that will build on these remarkable scientific and institutional achievements and that will continue to catapult lipid research at MUSC. The overall objective is to capitalize on the exceptional strengths at MUSC in lipid biology with specific goal to: 1) define and develop specific thematic programmatic activities focusing on important pathobiology based on Center activities (e.g. cancer, neurodegeneration, metabolic disorders and infection/inflammation); 2) enhance translational research; 3) enhance mentoring to meet the increasing challenges of the current funding environment; 4) enhance the function of the cores and position them to better serve thematic and translational goals; 5) complete the development of the novel Lipidomics Portal; and 6) develop and achieve sustainability of the cores. We anticipate that these activities will result in a highly developed interdisciplinary research center with a critical mass of collaborative, independently and programmatically funded investigators in an evolving area of research of major significance to cancer biology, aging, inflammation, diabetes, neurodegeneration and infectious diseases.

描述（由申请人提供）：南卡罗来纳医科大学 (MUSC) 的新兴脂质组学和病理生物学中心建立在 COBRE 前两个阶段取得的实质性成就的基础上。其中包括指导 19 名目标初级教师研究人员，其中 14 名获得了独立的校外资助，目标教师在同行评审期刊上发表了 193 篇出版物，超过 25 名 MUSC 研究教师参与 COBRE 活动，以及开发和增强高度成功的、创新的科学核心设施，包括脂质组学的独特核心、动物病理学的新兴重点核心（专注于基于脂质的动物模型）以及专注于脂质酶和靶标的蛋白质核心。 COBRE 在招募少数族裔 (2) 和女性 (10) 作为目标教员方面也非常成功。组织假说指出，生物活性脂质和相关代谢物的整体构成了调节关键生理功能的不同途径的复杂网络。反过来，这些途径的功能障碍会导致特定疾病的病理学。平衡脂质的生物学意义是由于研究脂质和脂质相互作用蛋白的相对困难而引起的独特考虑。这就需要开发有能力的共享设施和协作努力，以利用不同的学科和专业知识来解决具体问题。因此，下一阶段的战略重点是在 MUSC 建立一个独立的脂质组学和病理生物学中心，该中心将建立在这些卓越的科学和机构成就的基础上，并将继续推动 MUSC 的脂质研究。总体目标是利用 MUSC 在脂质生物学方面的特殊优势，具体目标是：1）根据中心活动（例如癌症、神经退行性变、代谢紊乱和感染/炎症）确定和开发侧重于重要病理学的特定主题计划活动; 2）加强转化研究； 3）加强指导，应对当前融资环境日益严峻的挑战； 4）增强核心功能，使其更好地服务于主题和转化目标； 5) 完成新型脂质组学门户网站的开发； 6) 开发并实现核心的可持续性。我们预计这些活动将建立一个高度发达的跨学科研究中心，在一个对癌症生物学、衰老、炎症、糖尿病、神经退行性疾病和传染病具有重大意义的不断发展的研究领域中，拥有大量合作、独立和有计划资助的研究人员。