Antipsychotic Treatment Effects on Attention & Working Memory in Schizophrenia

抗精神病治疗对注意力的影响

基本信息

批准号：
8196723
负责人：
James L Reilly
金额：
$ 16.62万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-12-08 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8196723
关键词：
Accounting Address Affect Aftercare Animal Model Animals Antipsychotic Agents Area Attention Base of the Brain Behavior Behavioral Brain Brain imaging Chronic Clinic Clinical Clinical Investigator Clinical Trials Clinical Trials Design Cognitive Cognitive deficits Data Data Analyses Data Collection Delusions Development Direct Costs Disease Dopamine D1 Receptor Effectiveness Event Failure Functional Magnetic Resonance Imaging Goals Hallucinations Human Image Impaired cognition Individual Investigation K-Series Research Career Programs Knowledge Laboratories Laboratory Study Learning Location Maintenance Memory impairment Mental disorders Methodology Modeling Neurobehavioral Manifestations Neurocognitive Neurocognitive Deficit Neuropharmacology Noise Patients Performance Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Population Prefrontal Cortex Prevalence Productivity Public Health Receptor Activation Regulation Research Research Activity Research Personnel Role Schizophrenia Sensory Series Short-Term Memory Support System Symptoms System Techniques Testing Time Training Training Activity Translating Validation Work base behavioral pharmacology career career development cognitive function cognitive neuroscience comparative trial design distraction drug development experience first episode schizophrenia functional disability investigator training memory process mental representation neocortical neuroimaging novel oculomotor operation prevent programs relating to nervous system response role model skills standard care success tool treatment effect

项目摘要

Deficits in attention and working memory, the abilities that allow individuals to selectively attend to and mentally maintain and manipulate information to guide behavior, are considered to be central components to the cognitive dysfunction in schizophrenia. While advances in antipsychotic pharmacotherapy have resulted in important gains for treating symptoms of hallucinations and delusions, cognitive deficits have been far less responsive to standard treatments. Developing novel pharmacological agents to target these persistent cognitive deficits is an important goal of ongoing schizophrenia treatment research. This is a broad and multidimensional problem involving drug development and translational animal models. In the end, success will depend on the ability of trained investigators who have the expertise and tools to evaluate drug effects on neurocognitive systems in the clinic. The aim of this proposed career development program is to facilitate the candidate's efforts to become a successful independent clinical investigator in this area. Primary objectives of this career development program are to provide the candidate with advanced training in three main areas: (1) functional brain imaging; (2) cognitive neuroscience and neuropharmacological models of working memory; and (3) clinical trial design and methodology. Research activities will focus on designing and conducting behavioral and event-related functional neuroimaging studies of working memory and attention using paradigms translated from animal models to examine antipsychotic treatment effects on these core cognitive deficits in schizophrenia. These activities will prepare the candidate for an independent program of research examining disturbances in functional brain systems that underlie cognitive impairments in schizophrenia and how these are impacted by antipsychotic treatments. The knowledge and skills gained from proposed training and research activities will be important for the Pi's career objective to use integrative approaches to investigate the effectiveness of pharmacological treatments developed to reduce cognitive impairments in schizophrenia.

注意力和工作记忆的缺陷，允许个人选择性参加的能力和精神维护和操纵信息以指导行为，被认为是核心组成部分精神分裂症的认知功能障碍。抗精神病药物药物疗法的进步已导致在治疗幻觉和妄想症状的重要收益中，认知缺陷少得多对标准治疗的反应。开发新型的药理学剂来针对这些持久认知缺陷是正在进行的精神分裂症治疗研究的重要目标。这是一个广泛的涉及药物开发和转化动物模型的多维问题。最后，成功将取决于具有专业知识和工具来评估药物影响的训练有素的调查人员的能力关于诊所的神经认知系统。该提议的职业发展计划的目的是促进候选人在这一领域成为成功的独立临床研究者的努力。基本的该职业发展计划的目标是为候选人提供三个中的高级培训主要区域：（1）功能性脑成像；（2）认知神经科学和神经药理模型工作记忆；（3）临床试验设计和方法论。研究活动将集中于设计并进行行为和事件相关的功能性神经影像学研究，对工作记忆和使用从动物模型翻译的范式来检查抗精神病药物治疗对这些精神分裂症的核心认知缺陷。这些活动将为候选人做好准备研究研究的研究计划，这些功能性脑系统的干扰是认知障碍的基础的在精神分裂症中以及如何受到抗精神病药的影响。获得的知识和技能通过拟议的培训和研究活动对于使用综合性的PI的职业目标将很重要研究为了降低认知而开发的药理治疗有效性的方法精神分裂症的障碍。