ARCHAEAL RNA LIGASE

古细菌RNA连接酶

• 批准号: 8171323
• 负责人: DIETER SOLL
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171323
• 关键词: Animals; Archaeal RNA; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Human Identifications; Institution; Life; Ligase; Ligation; Literature; Pathway interactions; Pharmaceutical Preparations; RNA; RNA Ligase (ATP); RNA Splicing; Research; Research Personnel; Resources; Source; Transfer RNA; Tropical Disease; Trypanosoma; United States National Institutes of Health; Yeasts; pathogen; tRNA Ligase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In life two different RNA ligation pathways involved in RNA splicing can be pinpointed. The yeast type and the animal/archaeal type ligation pathway. While human mainly utilize the animal type RNA ligation pathway, many pathogens like Leihsmania and Trypanosome rely on the yeast-type tRNA ligation pathway. Hence the yeast type tRNA ligase is a good target to develop a medication against several tropical diseases. Identification of the archaeal RNA ligase should inspire the identification of the human tRNA ligase which has been described in literature as very unstable.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 在生命中，可以查明参与 RNA 剪接的两种不同的 RNA 连接途径。酵母类型和动物/古细菌类型连接途径。虽然人类主要利用动物型 RNA 连接途径，但许多病原体（如莱氏曼原虫和锥虫）依赖于酵母型 tRNA 连接途径。因此，酵母型 tRNA 连接酶是开发针对多种热带疾病的药物的良好靶点。 古细菌 RNA 连接酶的鉴定应该会启发人类 tRNA 连接酶的鉴定，文献中将其描述为非常不稳定。