Research Support Core C: Analytical Core

研究支持核心 C：分析核心

• 批准号: 8055830
• 负责人: David W. Murray
• 金额: $ 19.42万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8055830
• 关键词: Address; Administrator; Aging; Analytical Chemistry; Area; Arts; Award; Back; Basic Science; Bayesian Analysis; Bioinformatics; Biological; Biological Markers; Biometry; Biostatistical Methods; Biotechnology; Blood specimen; Budgets; Calibration; Characteristics; Chemicals; Chemistry; Cluster Analysis; Collection; Community Health; Complex; Computer Systems; Computer software; Computers; Computing Methodologies; Core Facility; Coupled; Data; Data Analyses; Data Set; Detection; Development; Devices; Digestion; Disease; Ecology; Education; Education and Outreach; Educational Intervention; Educational process of instructing; Elements; Engineering; Ensure; Environment; Equipment; Equipment and Supplies; Experimental Designs; Faculty; Failure; Fees; Fees and Charges; Flame Ionization; Fluorescence; Fostering; Freezing; Funding; Gases; Genetic; Goals; Grant; Health; High Pressure Liquid Chromatography; Housing; Human; Human Resources; Inorganic Chemicals; Instruction; Internet; Interruption; Ions; Journals; Knowledge; Laboratories; Laboratory Research; Lead; Letters; Libraries; Link; Liquid Chromatography; Liquid substance; Location; Mails; Maintenance; Measurement; Measures; Mentorship; Mercury; Mercury Compounds; Metals; Methodology; Methods; Modeling; Natural graphite; Optics; Organic Chemicals; Organic Chemistry; Plasma; Poison; Polychlorinated Biphenyls; Positioning Attribute; Postdoctoral Fellow; Power Sources; Preparation; Procedures; Process Measure; Program Research Project Grants; Programming Languages; Protocols documentation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Risk; Roentgen Rays; Role; Running; SHFM1 gene; Sampling; Science; Scientist; Services; Solid; Solvents; Specialist; Statistical Computing; Statistical Methods; Structure; Students; Superfund; System; Technical Expertise; Techniques; Text; The Sun; Time; Trace metal; Training; Training Support; Translational Research; Universities; Work; absorption; analytical tool; base; computer network; cost; data management; design; detector; experience; firewall; graduate student; innovation; insight; instrument; instrumentation; interest; knowledge base; laboratory facility; liquid chromatography mass spectrometry; medical schools; meetings; member; mercury fumes; microwave electromagnetic radiation; novel; operation; organic contaminant; phthalates; professor; programs; purge; remediation; research study; software systems; soil sampling; sound; stable isotope; statistical center; statistics; technique development; tool; toxicant; training project; vapor; volatile organic compound

The Analytical Core is comprised of two research support activities; chemistry and biostatistics. The goals of the core are to provide technical expertise, a support staff, and research tools necessary to make quantitative assessments of the chemicals that will be studied in this project, and to evaluate the exposures and risks associated with these chemicals. The Chemistry component of the Core will use an existing infrastructure of instrumentation and technical support associated with Brown University's Environmental Chemistry Facility to provide a managed set of laboratories and analytical facilities that will be shared among all the research projects to detect and quantify organic and inorganic compounds that are considered hazardous to human health. The Biostatistical component will provide statistical methodology and computational support for experimental design and data analysis for the research projects. The expertise from the two components will also be integrated to ensure comprehensive analysis of the chemicals and their health risks. There are five specific aims proposed in the Analytical Core: 1) Provide centralized facilities for the analysis of organic and inorganic compounds, and for biostatistical analysis; 2) Provide a Leader who will be responsible for the management of the chemistry component of the Core and a Leader who will be responsible for the biostatistical capabilities; 3) Provide the knowledge base and personnel to support investigators in the development of appropriate and innovative techniques to satisfy their specific analytical chemistry and biostatiistical goals; 4) Provide expendable supplies, equipment parts, and the computational capabilities to maintain a state-of-the-art facility; and 5) Provide training for students, technicians, and researchers using core facilities. During the initial award period, funds were available to enhance the analytical capabilities of the instruments and facilities specifically focused on the detection and quantification of organic compounds, and mercury analysis of vapors, liquids, and solids. Accomplishment of Aims 1-5 will use the existing infrastructure at Brown, and a knowledge base and support staff for machine maintenance, computational analyses, and training. This model of management has worked well during the initial funding period and will continue to support the research projects in this study and the analytical facilities that will be shared among the projects

分析核心由两项研究支持活动组成：化学和生物统计学。的目标 核心是提供技术专长、支持人员和必要的研究工具，以实现 对该项目中将研究的化学品进行定量评估，并评估暴露情况 以及与这些化学品相关的风险。核心的化学部分将使用现有的 与布朗大学环境相关的仪器和技术支持基础设施 化学设施提供一套受管理的实验室和分析设施，这些设施将在 检测和量化所考虑的有机和无机化合物的所有研究项目 对人体健康有害。生物统计部分将提供统计方法和 研究项目的实验设计和数据分析的计算支持。专业知识 这两个组成部分也将被整合，以确保对化学品和 他们的健康风险。分析核心提出了五个具体目标： 1) 提供集中化 有机和无机化合物分析以及生物统计分析设施； 2）提供一个 领导者将负责核心化学部分的管理和领导者 谁将负责生物统计能力； 3) 提供知识库和人员 支持研究人员开发适当的创新技术以满足他们的具体要求 分析化学和生物统计目标； 4）提供消耗品、设备零件和 维持最先进设施的计算能力； 5）为学生提供培训， 使用核心设施的技术人员和研究人员。在最初的奖励期间，资金可用于 提高专门针对检测和检测的仪器和设施的分析能力 有机化合物的定量，以及蒸气、液体和固体的汞分析。成就 目标 1-5 将使用布朗现有的基础设施以及机器的知识库和支持人员 维护、计算分析和培训。这种管理模式在改革开放初期取得了良好的效果 初始资助期并将继续支持本研究中的研究项目和分析 项目之间共享的设施