Making and breaking the left-right axis: Laterality in development and disease

左右轴的形成和破坏：发育和疾病的偏侧性

• 批准号: 8597643
• 负责人: MARNIE E HALPERN
• 金额: $ 0.6万
• 依托单位: CARNEGIE INSTITUTION OF WASHINGTON, D.C.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-12 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597643
• 关键词: Address; Behavior; Communities; Complex; Congenital Disorders; Congresses; Development; Developmental Biology; Disease; Disease model; Educational workshop; Embryo; Event; Funding; Generations; Handedness; Heart; Human; International; Invertebrates; Joints; Journals; Left; Link; Liver diseases; Mexico; Modeling; Nervous System Physiology; Nervous system structure; Organ; Participant; Pattern; Polycystic Kidney Diseases; Postdoctoral Fellow; Process; Research Personnel; Side; Societies; System; Time; Travel; Work; body system; ciliopathy; congenital heart disorder; cost; graduate student; insight; interest; meetings; public health relevance; symposium

DESCRIPTION (provided by applicant): This is an application for support of a conference entitled "Making and breaking the left-right axis: Laterality in development and disease" to be held June 15-16, 2013 in Cancun, Mexico, just prior to the joint Society for Developmental Biology 72nd Annual Meeting and the 17th International Congress of Developmental Biology. The objective of this satellite symposium is to bring together researchers working on invertebrate and vertebrate models for an up-to-date presentation of the latest results on the development and disease relevance of left-right asymmetry. Although there have been many exciting recent developments in the field, a meeting on this specific subject has not been held since 2001, when a small workshop was sponsored by the Instituto Juan March in Madrid. Since then, numerous discoveries have been made on how sidedness is established and maintained in the embryo and the common disorders that can result from abnormal left-right patterning, such as ciliopathies, polycystic kidney and liver disease and complex congenital heart disease. New insights have also been obtained on the significance of laterality in the developing nervous system and its influence on behavior. The group of invited speakers will, for the first time, unite researchers working on left-right symmetry breaking in diverse developmental models and organ systems. The high degree of enthusiasm expressed by researchers who have already agreed to participate indicates the timeliness and level of interest for a symposium on this topic. We anticipate that this symposium will attract approximately 100 participants, with the size and format of the event encouraging maximal interaction among the attendees. The co-organizers will also inform the scientific community more broadly by serving as guest editors of a journal issue dedicated to the symposium topic on the development of L-R asymmetry.

描述（由申请人提供）：这是一份支持题为“左右轴的形成和打破：发育和疾病中的偏侧性”的会议的申请，该会议将于 2013 年 6 月 15 日至 16 日在墨西哥坎昆举行。发育生物学学会联合第 72 届年会和第 17 届国际发育生物学大会。本次卫星研讨会的目的是汇集无脊椎动物和脊椎动物模型研究人员，最新介绍左右不对称的发展和疾病相关性的最新结果。尽管该领域最近取得了许多令人兴奋的进展，但自 2001 年以来就再也没有举行过关于这一特定主题的会议，当时马德里的胡安马奇研究所主办了一次小型研讨会。从那时起，人们在胚胎中如何建立和维持侧面性以及左右模式异常可能导致的常见疾病（如纤毛病、多囊肾和肝病以及复杂的先天性心脏病）方面取得了许多发现。关于偏侧性在神经系统发育中的重要性及其对行为的影响也获得了新的见解。受邀演讲者群体将首次联合起来 研究人员致力于研究不同发育模型和器官系统中左右对称性的破坏。已经同意参加的研究人员所表现出的高度热情表明了对该主题的研讨会的及时性和兴趣程度。 我们预计本次研讨会将吸引大约 100 名与会者，活动的规模和形式鼓励与会者之间进行最大程度的互动。联合组织者还将担任专门讨论 L-R 不对称性发展研讨会主题的期刊客座编辑，为科学界提供更广泛的信息。