Conduct of studies to evaluate the toxic and carcinogenic potentiial

进行研究以评估毒性和致癌潜力

• 批准号: 8602480
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 69.39万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8602480
• 关键词: Adult; Animals; Chemicals; Chronic; Development; Dibutyl Phthalate; Diet; Environment; Exposure to; Goals; Histopathology; Human; Lactation; Life; Mus; Perinatal; Perinatal Exposure; Phase; Plasticizers; Pregnancy; Rattus; Reporting; Toxic effect; Toxicity Tests; Writing; carcinogenicity; critical period; hazard; phthalates

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of two phthalate plasticizers, dibutyl phthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP), following dietary exposures. 2-Year chronic toxicity and carcinogenicity studies of DBP and DEHP are in the in life phase. Both of these studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the DBP study, rats were exposed perinatally prior to the start of 2-year study, while standard studies are being conducted in mice. DEHP includes two 2-year rat studies, one with perinatal exposure and one without, to evaluate the effect of perinatal exposure. The DBP studies are in the histopathology/report writing phase. The DEHP studies are in the in life phase. Keywords: toxicity, carcinogenicity, diet, perinatal, phthalate, dibutyl phthalate, di(2-ethylhexyl)phthalate.

该项目的目的是在饮食暴露后评估两种邻苯二甲酸酯增塑剂（DBP）和DI（2-乙基己基）（DEHP）的慢性毒性和致癌性。 DBP和DEHP的2年慢性毒性和致癌性研究处于生命阶段。这两项研究都包括围产期暴露（妊娠和泌乳期间的暴露）。人类可能会通过环境类似地暴露于这些化合物。围产期暴露在关键的发育期间发生，与仅从成年开始的暴露相比，可能导致毒性/致癌性差异。在DBP的研究中，在2年研究开始之前，大鼠在围产期暴露，而在小鼠中进行了标准研究。 DEHP包括两项为期两年的大鼠研究，一项具有围产期暴露，一项无需评估围产期暴露的影响。 DBP研究处于组织病理学/报告写作阶段。 DEHP研究处于生命阶段。 关键词：毒性，致癌性，饮食，围产期，邻苯二甲酸酯，邻苯二甲酸二丁酯，DI（2-乙基己基）邻苯二甲酸酯。