Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估 α-蒎烯对实验动物的毒性和致癌潜力

• 批准号: 9162300
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 252.62万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9162300
• 关键词: Animals; Breathing; Chemicals; Chronic; Fertility; Flavoring; Goals; Human; Inhalation Exposure; Laboratory Animals; Life; Mus; National Toxicology Program; Phase; Process; Rattus; Risk; Self Care; Sperm Count Procedure; Sperm Motility; Toxic effect; Toxicity Tests; Turpentine; alpha-pinene; carcinogenicity; hazard; male; reproductive; Animals; Breathing; Chemicals; Chronic; Fertility; Flavoring; Goals; Human; Inhalation Exposure; Laboratory Animals; Life; Mus; National Toxicology Program; Phase; Process; Rattus; Risk; Self Care; Sperm Count Procedure; Sperm Motility; Toxic effect; Toxicity Tests; Turpentine; alpha-pinene; carcinogenicity; hazard; male; reproductive

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of alpha-pinene in rats and mice, following whole body inhalation exposure. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed through use of personal care and cleaning products as well as in lumber processing and building activities. 2-Year chronic toxicity and carcinogenicity studies of alpha-pinene are the in life phase. These studies include an assessment of fertility and sperm count and motility, as male reproductive effects are anticipated. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene

该项目的目的是评估大鼠和小鼠α-烯的慢性毒性和致癌性，随后全身吸入。在松节油和调味剂和香水中发现α-烯烯。可以通过使用个人护理和清洁产品以及木材处理和建筑活动来暴露人类。 α-烯烯的2年慢性毒性和致癌性研究是生命阶段。这些研究包括评估生育能力，精子计数和运动，因为预计男性生殖作用。 关键词：毒性，致癌性，吸入，α-细胞烯