CALCIUM ABSORPTION IN NEONATES FED WITH MOTHER'S MILK FORTIFIED WITH A DONOR

用捐赠者强化母乳喂养的新生儿的钙吸收

• 批准号: 8166693
• 负责人: STEVEN A ABRAMS
• 金额: $ 0.3万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166693
• 关键词: Body Composition; Bone Growth; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Grant; Growth; Human Milk; Infant; Institution; Milk; Minerals; Mothers; Neonatal; Nutrient; Outcome; Physiologic calcification; Premature Infant; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Very Low Birth Weight Infant; base; calcium absorption; feeding; neonate; nutrition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast milk is considered the nutrition of choice for infants, including premature infants in the Neonatal ICU (NICU). In the case of very low birth weight (VLBW) infants, this milk is generally supplemented with a human milk fortifier (HMF) in order to provide the additional nutrients that these babies require. We propose to investigate a HMF made from pasteurized donor human milk, in particular regarding calcium absorption, growth, bone mineral status, body composition, and feeding tolerance. We hypothesize that these study parameters will result in adequate outcomes with the use of the donor milk based HMF. The use of a human milk fortifier made from pasteurized donor human milk will provide adequate calcium absorption to preterm infants. In addition, this new fortifier will provide adequate growth and bone mineralization. Primary Aim: To determine calcium absorption in premature infants fed mother''s own milk fortified with pasteurized donor human milk fortifier. Secondary Aims: (1) To evaluate the growth, bone mineral status, and body composition of premature infants fed mother''s own milk fortified with pasteurized donor human milk fortifier, and, (2) To assess feeding tolerance (pilot data) in infants fed mother''s own milk fortified with pasteurized donor human milk.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 母乳被认为是婴儿的首选营养品，包括新生儿重症监护病房 (NICU) 中的早产儿。对于极低出生体重 (VLBW) 婴儿，这种牛奶通常会添加母乳强化剂 (HMF)，以提供这些婴儿所需的额外营养。我们建议研究由巴氏灭菌的捐赠母乳制成的 HMF，特别是在钙吸收、生长、骨矿物质状况、身体成分和喂养耐受性方面。我们假设这些研究参数将通过使用基于 HMF 的捐赠乳产生足够的结果。 使用由巴氏灭菌的捐赠母乳制成的母乳强化剂将为早产儿提供足够的钙吸收。此外，这种新的强化剂将提供足够的生长和骨矿化。 主要目的：确定用巴氏灭菌捐赠母乳强化剂强化母乳喂养的早产儿的钙吸收情况。 次要目标：(1) 评估用巴氏灭菌捐赠母乳强化剂强化母乳喂养的早产儿的生长、骨矿物质状况和身体成分，以及 (2) 评估喂养耐受性（试点数据）婴儿喂养的是母亲自己的母乳，并添加了经过巴氏灭菌的捐赠母乳。