ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES

造口婴儿的锌和铜排泄和吸收

• 批准号: 8356699
• 负责人: STEVEN A ABRAMS
• 金额: $ 1.02万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356699
• 关键词: Ceruloplasmin; Clinical Research; Copper; Enteral Feeding; Enteral Nutrition; Excretory function; Funding; Grant; Hour; Infant; Intestines; Measures; National Center for Research Resources; Ostomy; Output; Patients; Principal Investigator; Research; Research Infrastructure; Resources; Serum; Serum zinc level result; Source; Time; Total Parenteral Nutrition; United States National Institutes of Health; Zinc; absorption; cost; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT We propose to examine the absorption and excretion of zinc and copper in infants with ostomies. This will be accomplished by measuring baseline excretion and serum levels of zinc, copper, and ceruloplasmin, and by utilizing stable isotopes of zinc and copper to measure absorption and excretion. When an infant with an ostomy is receiving primarily total parenteral nutrition (TPN) with minimal or no enteral feeds, we will collect ostomy output for 24 hours to measure zinc and copper excretion, and will measure serum zinc, copper, and ceruloplasmin levels. We will utilize stable isotopes of zinc and copper at two time points: when the infant still has the ostomy and is receiving primarily enteral nutrition without TPN, and lastly, when/if the patients ostomy is removed with the bowels reanastamosed and the patient is stable on enteral feeds.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 抽象的 我们建议检查造口婴儿体内锌和铜的吸收和排泄情况。这将通过测量锌、铜和铜蓝蛋白的基线排泄和血清水平，并利用锌和铜的稳定同位素来测量吸收和排泄来实现。当造口婴儿主要接受全肠外营养 (TPN) 且极少或无肠内喂养时，我们将收集 24 小时的造口输出以测量锌和铜的排泄，并测量血清锌、铜和铜蓝蛋白水平。我们将在两个时间点使用锌和铜的稳定同位素：当婴儿仍然有造口并且主要接受肠内营养而不进行 TPN 时，最后，当/如果患者的造口被移除且肠道重新吻合并且患者情况稳定时肠内喂养。