Core D: Developmental/Pilot Research Core p367-377

核心 D：发展/试点研究核心 p367-377

• 批准号: 8595688
• 负责人: Peter G. Shields
• 金额: $ 7.69万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8595688
• 关键词: Address; Adolescent; Adult; Advertising; Affective; Area; Award; Cognitive; Cohort Studies; Collaborations; Complement; Comprehensive Cancer Center; Data; Decision Making; Development; Environment; Evaluation; Eye; Funding; Goals; Grant; Image; Individual; Industry; Intramural Research Program; Marketing; Modeling; Ohio; Outcome; Persons; Pilot Projects; Population; Prevalence; Research; Research Infrastructure; Research Priority; Research Project Grants; Research Support; Rural Population; Science; Series; Smokeless Tobacco; Tobacco; Universities; Urban Population; Vision; disorder risk; expectation; preference; research study

This Core of The Ohio State University Center of Excellence in Regulatory Tobacco Science (OSUCERTS) proposes to develop, implement, and evaluate the Developmental/Pilot Research Core (DPRC) for tobacco regulatory science. The overall vision of The Ohio State University Center of Excellence in Regulatory Tobacco Science (OSU-CERTS) is to serve as a national leader in providing relevant scientific data to support FDA regulatory decision making in the Center for Tobacco Products. The overall theme of OSU-CERTS is to understand the reasons for underlying tobacco-product preferences, especially dual and poly-use, and how these reasons influence use in an environment of ever-changing diverse types of tobacco products. The Center will integrate this theme in a series of adolescent and adult cohort studies conducted in natural settings, complemented by well-controlled experimental studies that allow for causal inference. To accomplish the above, we will utilize a population harm model, where harm to the population is the result of individual disease risk and the number of persons who are exposed (prevalence). The major research areas of the OSU-CERTS that will assist the FDA include the impact of advertising and marketing; cognitive and affective influences in decision making; a focus on smokeless tobacco (ST) and dual use; use of both urban and rural populations to enhance generalizability; and synergistic studies that cover the range of tobacco users from adolescents to adults. Our Center will address 11 of 56 research priorities set forth by the FDA in January, 2012. The primary goal of the DPRC is to build upon our existing research projects and also to establish new ones with developmental monies; pilot projects may address the 11 current OSU-CERTS FDA research priorities, or new ones. Pilots that can support research across TCORS will be encouraged. There will be an expectation that awardees utilize the OCU-CERTS research infrastructure and cores. The review mechanism will be provided by the Comprehensive Cancer Center's (CCC) Intramural Research Program, which should be considered institutional support. Examples of pilots, as described below, include an evaluation of graphic warning images and eye tracking; and a study of industry documents about emerging products. A total of $600,000 will fund 20 pilots over years 2-5 of the grant, which includes institutional support from the CCC.

俄亥俄州立大学监管烟草科学卓越中心（Ousucerts）的核心 建议开发，实施和评估开发/飞行员研究核心（DPRC） 烟草监管科学。俄亥俄州立大学监管卓越中心的整体愿景 烟草科学（OSU-CERTS）是在提供相关科学数据以支持的国家领导者 烟草产品中心的FDA监管决策。 OSU-Certs的总体主题是 了解潜在的烟草产品偏好的原因，尤其是双重和多用途，以及如何 这些原因影响在不断变化的多种烟草产品的环境中使用。中心 将在一系列在自然环境中进行的青少年和成人队列研究中整合这个主题， 辅以良好控制的实验研究，可以进行因果推断。完成 上面，我们将利用人口危害模型，其中对人口的伤害是个体疾病的结果 风险和暴露的人数（患病率）。 OSU-Certs的主要研究领域 这将有助于FDA包括广告和营销的影响；认知和情感影响 决策;专注于无烟烟草（ST）和双重用途；使用城市和农村人口 提高普遍性；以及涵盖从青少年到的烟草用户范围的协同研究 成年人。我们的中心将解决FDA 2012年1月提出的56项研究优先事项中的11个。 DPRC的目标是建立我们现有的研究项目，并建立具有发展的新项目 货币；试点项目可以解决当前的11个OSU-CERTS FDA研究重点或新的研究重点。 可以鼓励可以支持跨TCOR的研究的飞行员。会有一个被授权人 利用OCU-Certs研究基础设施和核心。审核机制将由 综合癌症中心（CCC）的壁内研究计划，应视为机构 支持。如下所述，飞行员的示例包括对图形警告图像和眼睛的评估 追踪;以及有关新兴产品的行业文件的研究。总共60万美元将资助20名飞行员 在赠款的2 - 5年中，包括CCC的机构支持。