Wisconsin Center for the Neuroscience and Psychophysiology of Meditation

威斯康星冥想神经科学和心理生理学中心

• 批准号: 8551840
• 负责人: Richard J Davidson
• 金额: $ 178.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8551840
• 关键词: Academic Medical Centers; Adult; Allergens; American; Asthma; Behavioral; Belief; Biological; Biological Process; Brain; Breathing; Centers of Research Excellence; Chronic; Cognitive; Compassion; Complementary and alternative medicine; Conscious; Development; Disease; Electroencephalography; Electromyography; Face; Grant; Health; Healthcare; Hormonal; Human; Individual; Inflammation; Inflammatory Response; Intervention; Love; Lung; Measures; Mediating; Medical; Meditation; Methods; Neurosciences; Participant; Performance; Personal Satisfaction; Phase; Protocols documentation; Psyche structure; Psychophysiology; Randomized; Recovery; Recruitment Activity; Reporting; Research; Research Personnel; Sampling; Signal Transduction; Sleep; Stress; Structure; Surveys; Testing; Time; Training; Treatment Efficacy; United States; United States National Institutes of Health; Universities; Waiting Lists; Wakefulness; Wisconsin; Work; base; biobehavior; comparison group; design; emotion regulation; emotional stimulus; experience; improved; indexing; inflammatory marker; mental practice; mindfulness; mindfulness meditation; mindfulness-based stress reduction; neural circuit; novel; programs; public health relevance; relating to nervous system; response; stress related disorder; teacher

DESCRIPTION (provided by applicant): We propose to extend our Center for Excellence for Research in Complementary and Alternative Medicine (CERC)-The Wisconsin Center for the Neuroscience and Psychophysiology of Meditation-for a second five-year period. This will be a highly focused center dedicated to novel and cutting edge research on the mechanisms by meditation works. In the next five-year period, two of the original three projects will continue wih important new components. Project 1 (Davidson, PI) will examine the impact of the explicit use of mindfulness and loving-kindness-compassion strategies on emotion regulation, specifically neural, hormonal and behavioral (including facial electromyography in the scanner) indices of reactivity to and recovery from pictures of human suffering and flourishing. Project 2 will be directed by William Busse, a well-known asthma researcher at the University of Wisconsin-Madison. Based upon collaborative work by Busse and Davidson that established the neural circuitry activated by asthma-relevant emotional stimuli that predicts inflammatory response in asthmatics, we propose to examine the impact of Mindfulness-Based Stress Reduction (MBSR) on altering the neural signals and inflammatory response in the lung in a group of asthmatics. The third project will be focused on sleep and directed by Giulio Tononi. This project will extend our previous findings by examining whether the increase in gamma oscillations during NREM sleep in meditators is associated with changes in mental content during sleep. In addition, relations between sleep and waking EEG and between sleep EEG changes and waking performance on cognitive and attentional measures, and experience sampling measures, will be studied. Each of these projects will be conducted with the identical group of participants recruited through our Core that will include those randomized assigned to MBSR, the active comparison intervention we explicitly developed to test against MBSR~the Health Enhancement Program (HEP)~or a wait list (WL), as well as Long-Term Meditators (LTMs). We believe that the understanding of the mechanisms by which meditation produces changes in behavioral and biological processes will be dramatically advanced through the work of this CERC.

描述（由申请人提供）：我们建议将我们的补充和替代医学卓越研究中心（CERC）——威斯康星冥想神经科学和心理生理学中心——延长第二个五年期。这将是一个高度集中的中心，致力于通过冥想作品对机制进行新颖和前沿的研究。在接下来的五年中，最初的三个项目中的两个将继续进行，并添加重要的新内容。项目 1（戴维森，PI）将研究明确使用正念和慈爱同情策略对情绪调节的影响，特别是神经、激素和行为（包括扫描仪中的面部肌电图）对图片的反应和恢复指数人类的苦难与繁荣。项目2将由威斯康星大学麦迪逊分校著名哮喘研究员William Busse 指导。基于 Busse 和 Davidson 的合作工作，建立了由哮喘相关情绪刺激激活的神经回路，可预测哮喘患者的炎症反应，我们建议研究正念减压 (MBSR) 对改变神经信号和炎症反应的影响在一组哮喘患者的肺部。第三个项目将重点关注睡眠，由朱利奥·托诺尼 (Giulio Tononi) 执导。该项目将通过检查冥想者 NREM 睡眠期间伽马振荡的增加是否与睡眠期间心理内容的变化相关来扩展我们之前的发现。此外，还将研究睡眠和清醒脑电图之间的关系以及睡眠脑电图变化与认知和注意力测量以及经验采样测量的清醒表现之间的关系。这些项目中的每一个都将由通过我们的核心招募的同一组参与者进行，其中包括随机分配到 MBSR 的参与者，MBSR 是我们明确开发的用于测试 MBSR 的主动比较干预措施〜健康增强计划 (HEP)〜或等待名单（WL）以及长期冥想者（LTM）。我们相信，通过该 CERC 的工作，将极大地促进对冥想产生行为和生物过程变化的机制的理解。