Decision Making For Active Surveillance in Prostate Cancer Patients and Spouses

前列腺癌患者和配偶主动监测的决策

• 批准号: 8534064
• 负责人: Michael A Diefenbach
• 金额: $ 18.06万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534064
• 关键词: Address; Adverse effects; Advocate; Affective; Aftercare; Ally; Anxiety; Belief; Cancer Patient; Cognitive; Data; Data Collection; Decision Making; Diagnosis; Disease; Early treatment; Erectile dysfunction; Future; Goals; Individual; Informal Social Control; Intervention; Interview; Lead; Literature; Malignant Neoplasms; Malignant neoplasm of prostate; Memorial Sloan-Kettering Cancer Center; Methods; Participant; Patients; Persons; Physicians; Play; Process; Prostate-Specific Antigen; Psychological Factors; Questionnaires; Recruitment Activity; Regimen; Reporting; Research; Role; Screening for cancer; Services; Social support; Spouses; Staging; United States; Urinary Incontinence; Urology; active method; cancer site; clinical practice; cognitive function; insight; irritation; medical schools; men; preference; screening; social; theories

DESCRIPTION (provided by applicant): Prostate cancer is the most common site of cancer in men in the United States with over 240,000 men diagnosed with prostate cancer in 2011. Over the past years, widespread prostate specific antigen (PSA) screening has resulted in the earlier detection of these cancers. Screening has also led to controversy as men with very early stage disease are being treated when it is not clear to what extent treatment may be of benefit to them. Many clinicians agree that early stage disease is being over treated and it is estimated that 27-56% of men who undergo treatment for early stage prostate cancer can be managed effectively with active surveillance (AS). Given the potential for significant side-effects (e.g., erectile dysfunction, urinary incontinence, and bowl irritation) associated with treatment, AS is an important and viable alternative for patients with low-grade disease. Physicians have noticed that psychological factors such as anxiety or certain disease and treatment related beliefs may be influencing men and their partners to select active treatment (AT) over AS. In addition, intimate partners often exert an important influence of treatment choice as they are the primary social support for cancer patients. These anecdotal observations are supported by theory (i.e., self- regulation theory) and reports in the literature. However, a systematic examination of the influence of these cognitive-affective and social factors on the decision to decide on and adhere to an AS regimen is missing. The present application aims to investigate the decision making process for AS using a theory-guided self- regulation approach focusing on cognitive, affective and social/partner factors. This will be the first comprehensive examination of the contribution of affective and cognitive processes to decision making for AS. It will also be the first in this literature to include the perspective of patients' partners on decision making through the use of qualitative and quantitative data collection methods. Thus, the specific aims are: 1) to explore the cognitive and affective treatment decision-making processes among prostate cancer patients who are eligible for active surveillance and their partners/close allies. Aim 2: To explor how patients arrived at their decision and to investigate the influence partners/close allies play in this process.

描述（由申请人提供）：前列腺癌是美国男性最常见的癌症部位，2011年超过240,000名被诊断出患有前列腺癌的男性。在过去的几年中，广泛的前列腺特异性抗原（PSA）筛查已导致早期发现这些癌症。筛查也引起了争议，因为当尚不清楚治疗对他们有益时，患有非常早期疾病的男性正在接受治疗。许多临床医生同意，早期疾病正在过度治疗，据估计，可以通过主动监测（AS）有效地管理治疗早期前列腺癌的男性。考虑到与治疗相关的重要副作用（例如勃起功能障碍，尿失禁和碗刺激）的潜力，对于低级疾病的患者来说，这是重要且可行的替代方法。医师注意到，诸如焦虑或某些疾病和治疗信念之类的心理因素可能会影响男人及其伴侣，以选择主动治疗（AT）。此外，亲密的伴侣通常会对治疗选择的重要影响，因为它们是癌症患者的主要社会支持。这些轶事观察得到了理论（即自我调节理论）和文献报道的支持。但是，对这些认知影响和社会因素对决定并遵守As As As As As necimen的决定的影响的系统检查。本应用程序旨在调查决策过程，以使用理论指导的自我调节方法，重点是认知，情感和社会/伴侣因素。这将是对 AS决策的情感和认知过程。这也将是本文中第一个通过使用定性和定量数据收集方法来包括患者伴侣对决策做出决定的观点的观点。因此，具体目的是：1）探索有资格进行主动监视的前列腺癌患者的认知和情感治疗决策过程，及其伴侣/关闭盟友。目标2：探索患者如何做出决定并在此过程中调查伙伴/关闭盟友的影响。

项目成果

Social ecological influences on treatment decision-making in men diagnosed with low risk, localised prostate cancer.

• DOI: 10.1111/ecc.13697
• 发表时间: 2022-11
• 期刊: EUROPEAN JOURNAL OF CANCER CARE
• 影响因子: 2.1
• 作者: McIntosh, Megan;Opozda, Melissa J.;Short, Camille E.;Galvao, Daniel A.;Tutino, Rebecca;Diefenbach, Michael;Ehdaie, Behfar;Nelson, Christian
• 通讯作者: Nelson, Christian