Development of Anhedonia in High-Risk Adolescents

高危青少年快感缺失的发展

基本信息

批准号：
9424682
负责人：
Erika E Forbes
金额：
$ 56.28万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9424682
关键词：
Adolescence Adolescent Affective Age Anhedonia Behavior Behavioral Bipolar Disorder Brain Characteristics Communities Depressive disorder Development Diagnostic Dimensions Disease Exhibits Family history of Female First Degree Relative Functional Magnetic Resonance Imaging Functional disorder Goals Growth Internet Laboratories Learning Manic Measures Mental Depression Mental Health Modeling Mood Disorders Motivation National Institute of Mental Health Parents Participant Population Positive Valence Prevention approach Preventive Intervention Psychopathology Psychotic Disorders Recording of previous events Reporting Research Research Domain Criteria Rewards Risk Sampling Schedule Schizophrenia Severities Social Functioning Stimulus Symptoms System Techniques Testing Time Ventral Striatum Visit base depressive symptoms design experience high risk high risk population high-risk adolescents indexing innovation longitudinal design male neural correlate pleasure public health relevance recruit relating to nervous system response reward circuitry severe mental illness social

项目摘要

DESCRIPTION (provided by applicant): The proposed developmental psychopathology study examines the development of anhedonia during adolescence. Anhedonia, or difficulty experiencing pleasure in anticipation of or response to rewarding stimuli, is a coherent dimension within positive valence systems, has putative neural correlates in frontostriatal circuitry, and is relevant to several forms of serious psychopathology that emerge during adolescence. Anhedonia, a serious symptom, is likely to emerge during adolescence, and we propose that the development of anhedonia could precede the development of affective and schizophrenia-spectrum psychopathology. Specifically, the study examines developmental changes in subjective, neural, and behavioral aspects of anhedonia in 130 adolescents, age 13-17, who are either typically developing or have a first-degree relative with a history of depression, bipolar disorder, or schizophrenia-spectrum disorder. With the goal of understanding the development of anhedonia, the proposed study's aims include investigating (1) differences in anhedonia between high-risk and low-risk adolescents; (2) the development of anhedonia across adolescence; and (3) associations between anhedonia and depression, mania, and psychosis both cross-sectionally and longitudinally. Participants will complete 3 laboratory visits at annual intervals and 2 internet-based assessments, scheduled every 6 months between lab visits. Laboratory visits include self- and parent-report of anhedonia, psychopathology, and functioning; functional magnetic resonance imaging (fMRI) of frontostriatal function in response to monetary and social rewards; and behavioral tasks assessing reward motivation and reward learning. We will use longitudinal growth modeling to test our hypotheses. This study promises to advance mental health research by elucidating the development and pathophysiology of anhedonia, a dimension of psychopathology that occurs across disorders. Resulting understanding can inform the design of innovative, developmentally targeted prevention approaches.

描述（由申请人提供）：拟议的发展精神病理学研究检查了青春期快感缺乏的发展，或在预期或对奖励刺激做出反应时难以体验到快乐，是正价系统内的一个连贯维度，在额纹状体中具有推定的神经相关性。电路，并且与青春期出现的几种严重精神病理学相关，快感缺乏是一种严重的症状，很可能在青春期出现，我们建议这种发展。具体来说，这项研究调查了 130 名 13-17 岁青少年的主观、神经和行为方面的发展变化，这些青少年要么正在发育，要么已经有先发性快感缺失。与抑郁症、双相情感障碍或精神分裂症谱系障碍病史相关的学位为了了解快感缺失的发展，拟议研究的目的包括调查（1）高风险和低风险青少年之间快感缺乏的差异；（2）整个青春期快感缺乏的发展；以及（3）横向和纵向的快感缺乏与抑郁症、躁狂症和精神病之间的关联。每年完成 3 次实验室访问和 2 次基于互联网的评估，实验室访问之间每 6 个月安排一次，包括快感缺失、精神病理学和功能磁共振成像的自我报告和家长报告；（功能磁共振成像）对金钱和社会奖励的反应；以及评估奖励动机和奖励学习的行为任务。这项研究有望通过阐明奖励动机和病理生理学来推进心理健康研究。快感缺乏是跨疾病发生的精神病理学的一个维度，由此产生的理解可以为创新的、针对发育的预防方法的设计提供信息。