Development of Anhedonia in High-Risk Adolescents

高危青少年快感缺失的发展

• 批准号: 9424682
• 负责人: Erika E Forbes
• 金额: $ 56.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9424682
• 关键词: Adolescence; Adolescent; Affective; Age; Anhedonia; Behavior; Behavioral; Bipolar Disorder; Brain; Characteristics; Communities; Depressive disorder; Development; Diagnostic; Dimensions; Disease; Exhibits; Family history of; Female; First Degree Relative; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Growth; Internet; Laboratories; Learning; Manic; Measures; Mental Depression; Mental Health; Modeling; Mood Disorders; Motivation; National Institute of Mental Health; Parents; Participant; Population; Positive Valence; Prevention approach; Preventive Intervention; Psychopathology; Psychotic Disorders; Recording of previous events; Reporting; Research; Research Domain Criteria; Rewards; Risk; Sampling; Schedule; Schizophrenia; Severities; Social Functioning; Stimulus; Symptoms; System; Techniques; Testing; Time; Ventral Striatum; Visit; base; depressive symptoms; design; experience; high risk; high risk population; high-risk adolescents; indexing; innovation; longitudinal design; male; neural correlate; pleasure; public health relevance; recruit; relating to nervous system; response; reward circuitry; severe mental illness; social

 DESCRIPTION (provided by applicant): The proposed developmental psychopathology study examines the development of anhedonia during adolescence. Anhedonia, or difficulty experiencing pleasure in anticipation of or response to rewarding stimuli, is a coherent dimension within positive valence systems, has putative neural correlates in frontostriatal circuitry, and is relevant to several forms of serious psychopathology that emerge during adolescence. Anhedonia, a serious symptom, is likely to emerge during adolescence, and we propose that the development of anhedonia could precede the development of affective and schizophrenia-spectrum psychopathology. Specifically, the study examines developmental changes in subjective, neural, and behavioral aspects of anhedonia in 130 adolescents, age 13-17, who are either typically developing or have a first-degree relative with a history of depression, bipolar disorder, or schizophrenia-spectrum disorder. With the goal of understanding the development of anhedonia, the proposed study's aims include investigating (1) differences in anhedonia between high-risk and low-risk adolescents; (2) the development of anhedonia across adolescence; and (3) associations between anhedonia and depression, mania, and psychosis both cross-sectionally and longitudinally. Participants will complete 3 laboratory visits at annual intervals and 2 internet-based assessments, scheduled every 6 months between lab visits. Laboratory visits include self- and parent-report of anhedonia, psychopathology, and functioning; functional magnetic resonance imaging (fMRI) of frontostriatal function in response to monetary and social rewards; and behavioral tasks assessing reward motivation and reward learning. We will use longitudinal growth modeling to test our hypotheses. This study promises to advance mental health research by elucidating the development and pathophysiology of anhedonia, a dimension of psychopathology that occurs across disorders. Resulting understanding can inform the design of innovative, developmentally targeted prevention approaches.

 描述（由适用提供）：拟议的发育心理病理学研究研究了青少年期间Anhedonia的发展。 Anhedonia或艰难的经历在预期或对奖励刺激的反应中经历了愉悦，是正价系统中的一个连贯的维度，具有假定的神经元相关性，并且与青少年期间出现的几种严重的心理病理学相关。 Anhedonia是一种严重的症状，很可能在青少年期间出现，我们建议Anhedonia的发展可以在情感和精神分裂症 - 谱系心理病理学的发展之前。具体而言，该研究检查了130名青少年（13-17岁）的Anhedonia主观，神经和行为方面的发展变化，他们通常是发展或具有具有抑郁症，双相情感障碍或精神分裂症 - 谱系疾病的一级亲戚。为了理解Anhedonia的发展，拟议的研究的目的包括研究（1）高风险和低风险青少年之间的Anhedonia差异； （2）跨青少年的Anhedonia的发展； （3）在横截面和纵向上，阿尼多尼亚与抑郁，躁狂和精神病之间的关联。参与者将以年间和2次基于Internet的评估完成3次实验室访问，并计划在实验室访问之间每6个月进行一次。实验室访问包括Anhedonia的自我和父母报告，心理病理学以及功能；额叶功能的功能磁共振成像（fMRI）响应于货币和社会奖励；行为任务评估奖励动机和奖励学习。我们将使用纵向增长模型来检验我们的假设。这项研究有望通过阐明Anhedonia的发展和病理生理学来推动心理健康研究，这是跨疾病的心理病理学的维度。产生的理解可以为创新，开发的针对预防方法的设计提供信息。