Regulation of Hematopoietic Progenitors by de novo DNA Methylation

DNA 从头甲基化对造血祖细胞的调节

• 批准号: 8286460
• 负责人: MARGARET A. GOODELL
• 金额: $ 34.43万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286460
• 关键词: Aberrant DNA Methylation; Ablation; Acute Myelocytic Leukemia; Adult; Age; Age-Months; Anemia; Azacitidine; Binding; Blast Cell; Blood; Bone Marrow Transplantation; Candidate Disease Gene; Cell physiology; Cells; Clinical; DNA; DNA Methylation; DNA Methyltransferase; DNA Modification Methylases; DNA Structure; Data; Development; Disease; Dysmyelopoietic Syndromes; Enzymes; Epigenetic Process; Equilibrium; Frequencies; Future; Gene Expression; Genes; Genome; Goals; Hematopoiesis; Hematopoietic; Hematopoietic stem cells; Hypermethylation; Impotence; Incidence; Lead; Life; Link; Marrow; Mediating; Methylation; Modeling; Modification; Molecular; Mus; Mutation; Nucleic Acid Regulatory Sequences; Pathologic; Patients; Phenotype; Portraits; Production; Property; Proteins; Regulation; Role; Staging; Stem cells; cell type; clinical efficacy; improved; inhibitor/antagonist; insight; interest; progenitor; self-renewal; stem cell population; therapeutic development