Core B: Administrative Core

核心 B：行政核心

• 批准号: 10606564
• 负责人: MARGARET A. GOODELL
• 金额: $ 10.66万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606564
• 关键词: Animals; Annual Reports; Bioinformatics; Budgets; Cancer Center; Cells; Communication; Communities; Data; Ensure; Ethics; Evaluation; Experimental Designs; Feedback; Funding; Goals; Hematologic Neoplasms; Hematopoiesis; Human; Human Resources; Institution; Institutional Review Boards; Leadership; Malignant - descriptor; Manuscripts; Medicine; Monitor; Mus; Participant; Patients; Productivity; Program Evaluation; Program Reviews; Protocols documentation; Public Health Schools; Publications; Recommendation; Reporting; Reproducibility; Research; Research Personnel; Rice; Running; Suggestion; Texas; Training; Universities; Videoconferencing; Work; cohesion; college; good laboratory practice; high standard; improved; meetings; member; multidisciplinary; programs; sound; stressor

Project Summary This Program brings together a multidisciplinary team from Baylor College of Medicine, MD Anderson Cancer Center, Johns Hopkins Bloomberg School of Public Health, Texas A&M University, and Rice University to examine factors influencing the progression of clonal hematopoiesis to hematologic malignancy in mice and humans. To facilitate this bold undertaking, Core B (the Administrative Core) will coordinate the activities of the Program. This Core will (1) facilitate communication within and outside the Program by organizing monthly scientific meetings including all Program participants and quarterly meetings of Program leadership. The Core will facilitate an annual meeting including all participants and internal and external advisory board members to discuss progress and generate feedback. In addition, the Core will ensure that work is communicated to the scientific community in a timely fashion through presentations, publications, and data release. (2) The Core will be responsible for sound fiscal management including budgeting and distribution of funds. (3) The Core will coordinate ongoing evaluation of the Program through internal and external advisory boards and will use the advisory feedback to adjust the Program plans as needed. (4) The Core will be responsible for ensuring compliance with ethical considerations with regard to animal and IRB protocol approvals and good laboratory practices. The Core will ensure that all participating investigators have appropriate and current ethics training. The Core will also oversee research rigor by ensuring training of all Program personnel and rigorous review. This Core will also be responsible for statistical evaluation of plans in the Projects. Overall, Core B will facilitate the highest level of productivity throughout the Program, allowing each Project and Core to work together to achieve our overall goal of understanding how modifiable stressors cause expansion and malignant transformation in patients with clonal hematopoiesis.

项目概要 该项目汇集了来自贝勒医学院、MD 安德森癌症中心的多学科团队 中心、约翰霍普金斯大学彭博公共卫生学院、德克萨斯农工大学和莱斯大学 检查影响小鼠克隆造血进展为血液恶性肿瘤的因素 人类。为了促进这一大胆的事业，核心 B（行政核心）将协调 程序。该核心将 (1) 通过每月组织一次活动来促进计划内外的沟通 包括所有计划参与者在内的科学会议以及计划领导层的季度会议。核心 将促成一次由所有参与者以及内部和外部顾问委员会成员参加的年度会议，以 讨论进展并产生反馈。此外，核心将确保将工作传达给 通过演示、出版物和数据发布及时向科学界通报。 (2) 核心将 负责健全的财政管理，包括预算和资金分配。 (3) 核心将 通过内部和外部顾问委员会协调对该计划的持续评估，并将利用 根据需要调整计划计划的咨询反馈。 (4) 核心负责确保 遵守动物和 IRB 方案批准以及良好实验室方面的道德考虑 做法。核心将确保所有参与的调查人员接受适当且最新的道德培训。 核心还将通过确保所有计划人员的培训和严格审查来监督研究的严谨性。 该核心还将负责项目计划的统计评估。总体而言，核心 B 将促进 整个计划中最高水平的生产力，允许每个项目和核心共同努力 实现我们的总体目标，即了解可改变的压力源如何导致扩张和恶性 克隆性造血患者的转化。