Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

提高无创电神经调节的时空精度

基本信息

批准号：
9406395
负责人：
Don M Tucker
金额：
$ 73.23万
依托单位：
BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-23 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9406395
关键词：
Address Address Agreement Agreement Algorithms Algorithms Anterior Anterior BRAIN initiative BRAIN initiative Brain Brain Brain region Brain region Clinical Trials Clinical Trials Computer Simulation Computer Simulation Discrimination Discrimination Electricity Electricity Electrodes Electrodes Electroencephalography Electroencephalography Electronics Electronics Elements Elements Esthesia Esthesia Fingers Fingers Generations Generations Goals Goals Head Head High Performance Computing High Performance Computing Human Individual Individual Injectable Intervention Intervention Length Length Lidocaine Lidocaine Linux Linux Location Location Long-Term Depression Long-Term Depression Measurement Measurement Measures Measures Medical Device Medical Device Mental disorders Mental disorders Methods Methods Modeling Modeling Monitor Monitor Motor Motor Motor Cortex Motor Cortex Motor Evoked Potentials Motor Evoked Potentials Muscle Muscle Parahippocampal Gyrus Parahippocampal Gyrus Pattern Pattern Penetration Penetration Periodicity Periodicity Phase Phase Physics Physics Physiologic pulse Physiologic pulse Placebo Control Placebo Control Placebos Placebos Recovery Recovery Regulation Regulation Research Research Research Project Grants Research Project Grants Resolution Resolution Sales Sales Scientist Scientist Shoulder Shoulder Site Site Skin Skin Sleep Sleep Slow-Wave Sleep Slow-Wave Sleep Small Business Innovation Research Grant Small Business Innovation Research Grant Source Source Stimulus Stimulus Surface Surface System System Techniques Techniques Technology Technology Testing Testing Time Time Tissues Tissues Utah Utah Validation Validation Variant Variant brain abnormalities brain abnormalities clinical practice clinical practice commercialization commercialization cranium cranium design design digital digital efficacy testing efficacy testing electric impedance electrical impedance tomography experimental study experimental study flexibility flexibility frontal lobe frontal lobe human model improved improved meetings meetings neuroregulation neuroregulation novel novel operation operation prevent prevent programs programs response response sensor sensor signal processing signal processing simulation simulation source localization source localization spatiotemporal spatiotemporal tomography tool tool validation studies validation studies vector vector

项目摘要

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, the GTEN technology will be fully commercialized as a medical device through addressing four specific aims guided by the goals for noninvasive neuromodulation in the BRAIN Initiative. (1) We will improve focal current delivery at deep as well as superficial brain locations with a novel targeting algorithm (Discriminative Cortical Source Vectoring) implemented with a high resolution conductivity model of the human head. (2) Both simulation and experiment will be used to minimize extraneous stimulation to non target regions while quantifying current delivered to all brain regions. (3) We will design and test a placebo mode to allow definitive clinical trials. (4) Closed loop operation will be achieved by guiding the localization and phase of GTEN intervention with simultaneous monitoring of source-localized EEG. In the validation of closed-loop operation, the EEG rhythms will be those of slow wave sleep, and they will be hypothesized to be enhanced in both depth and length during the night's sleep. Completing the aims of this SBIR will create a dEEG-guided noninvasive dense array electrical neuromodulation technology as a powerful, precise, and inexpensive technology for both research and clinical practice.

该应用描述了测地线经颅电神经调节的商业化（GTEN）技术实现无创神经调节并提高时空精度。这 GTEN 系统支持 EEG 源分析和可配置的电神经调节 256 测地传感器网络的电极。 GTEN 现已向选定的研究客户推出测试版通过解决以下四个具体目标，技术将作为医疗设备全面商业化 BRAIN Initiative 中无创神经调节的目标。 (1) 我们将改善聚焦电流传输通过新颖的目标算法（判别性皮层源）识别深层和浅层大脑位置矢量）通过人体头部的高分辨率电导率模型实现。 (2) 模拟与实验将用于最大限度地减少对非目标区域的外部刺激，同时量化电流输送到所有大脑区域。 (3) 我们将设计并测试安慰剂模式，以进行最终的临床试验。 (4) 通过指导GTEN干预的定位和阶段，实现闭环运行同时监测源定位脑电图。在闭环操作验证中，脑电节律将是慢波睡眠，并且假设它们在深度和长度上都会增强晚上的睡眠。完成该 SBIR 的目标将创建一个 dEEG 引导的无创密集阵列电神经调节技术作为一种强大、精确且廉价的技术，可用于这两种研究和临床实践。