Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

提高无创电神经调节的时空精度

基本信息

批准号：
9406395
负责人：
Don M Tucker
金额：
$ 73.23万
依托单位：
BRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-23 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9406395
关键词：
Address Address Agreement Agreement Algorithms Algorithms Anterior Anterior BRAIN initiative BRAIN initiative Brain Brain Brain region Brain region Clinical Trials Clinical Trials Computer Simulation Computer Simulation Discrimination Discrimination Electricity Electricity Electrodes Electrodes Electroencephalography Electroencephalography Electronics Electronics Elements Elements Esthesia Esthesia Fingers Fingers Generations Generations Goals Goals Head Head High Performance Computing High Performance Computing Human Individual Individual Injectable Intervention Intervention Length Length Lidocaine Lidocaine Linux Linux Location Location Long-Term Depression Long-Term Depression Measurement Measurement Measures Measures Medical Device Medical Device Mental disorders Mental disorders Methods Methods Modeling Modeling Monitor Monitor Motor Motor Motor Cortex Motor Cortex Motor Evoked Potentials Motor Evoked Potentials Muscle Muscle Parahippocampal Gyrus Parahippocampal Gyrus Pattern Pattern Penetration Penetration Periodicity Periodicity Phase Phase Physics Physics Physiologic pulse Physiologic pulse Placebo Control Placebo Control Placebos Placebos Recovery Recovery Regulation Regulation Research Research Research Project Grants Research Project Grants Resolution Resolution Sales Sales Scientist Scientist Shoulder Shoulder Site Site Skin Skin Sleep Sleep Slow-Wave Sleep Slow-Wave Sleep Small Business Innovation Research Grant Small Business Innovation Research Grant Source Source Stimulus Stimulus Surface Surface System System Techniques Techniques Technology Technology Testing Testing Time Time Tissues Tissues Utah Utah Validation Validation Variant Variant brain abnormalities brain abnormalities clinical practice clinical practice commercialization commercialization cranium cranium design design digital digital efficacy testing efficacy testing electric impedance electrical impedance tomography experimental study experimental study flexibility flexibility frontal lobe frontal lobe human model improved improved meetings meetings neuroregulation neuroregulation novel novel operation operation prevent prevent programs programs response response sensor sensor signal processing signal processing simulation simulation source localization source localization spatiotemporal spatiotemporal tomography tool tool validation studies validation studies vector vector

Address Address Agreement Agreement Algorithms Algorithms Anterior Anterior BRAIN initiative BRAIN initiative Brain Brain Brain region Brain region Clinical Trials Clinical Trials Computer Simulation Computer Simulation Discrimination Discrimination Electricity Electricity Electrodes Electrodes Electroencephalography Electroencephalography Electronics Electronics Elements Elements Esthesia Esthesia Fingers Fingers Generations Generations Goals Goals Head Head High Performance Computing High Performance Computing Human Individual Individual Injectable Intervention Intervention Length Length Lidocaine Lidocaine Linux Linux Location Location Long-Term Depression Long-Term Depression Measurement Measurement Measures Measures Medical Device Medical Device Mental disorders Mental disorders Methods Methods Modeling Modeling Monitor Monitor Motor Motor Motor Cortex Motor Cortex Motor Evoked Potentials Motor Evoked Potentials Muscle Muscle Parahippocampal Gyrus Parahippocampal Gyrus Pattern Pattern Penetration Penetration Periodicity Periodicity Phase Phase Physics Physics Physiologic pulse Physiologic pulse Placebo Control Placebo Control Placebos Placebos Recovery Recovery Regulation Regulation Research Research Research Project Grants Research Project Grants Resolution Resolution Sales Sales Scientist Scientist Shoulder Shoulder Site Site Skin Skin Sleep Sleep Slow-Wave Sleep Slow-Wave Sleep Small Business Innovation Research Grant Small Business Innovation Research Grant Source Source Stimulus Stimulus Surface Surface System System Techniques Techniques Technology Technology Testing Testing Time Time Tissues Tissues Utah Utah Validation Validation Variant Variant brain abnormalities brain abnormalities clinical practice clinical practice commercialization commercialization cranium cranium design design digital digital efficacy testing efficacy testing electric impedance electrical impedance tomography experimental study experimental study flexibility flexibility frontal lobe frontal lobe human model improved improved meetings meetings neuroregulation neuroregulation novel novel operation operation prevent prevent programs programs response response sensor sensor signal processing signal processing simulation simulation source localization source localization spatiotemporal spatiotemporal tomography tool tool validation studies validation studies vector vector

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项目摘要

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, the GTEN technology will be fully commercialized as a medical device through addressing four specific aims guided by the goals for noninvasive neuromodulation in the BRAIN Initiative. (1) We will improve focal current delivery at deep as well as superficial brain locations with a novel targeting algorithm (Discriminative Cortical Source Vectoring) implemented with a high resolution conductivity model of the human head. (2) Both simulation and experiment will be used to minimize extraneous stimulation to non target regions while quantifying current delivered to all brain regions. (3) We will design and test a placebo mode to allow definitive clinical trials. (4) Closed loop operation will be achieved by guiding the localization and phase of GTEN intervention with simultaneous monitoring of source-localized EEG. In the validation of closed-loop operation, the EEG rhythms will be those of slow wave sleep, and they will be hypothesized to be enhanced in both depth and length during the night's sleep. Completing the aims of this SBIR will create a dEEG-guided noninvasive dense array electrical neuromodulation technology as a powerful, precise, and inexpensive technology for both research and clinical practice.

该应用描述了地球经颅电神经调节的商业化（GTEN）通过提高时空精度实现无创神经调节的技术。这 GTEN系统可以使用256启用EEG源分析和可配置的电气调节测量传感器网的电极。现在在Beta版本中向选定的研究客户发行了GTEN 通过解决由四个特定目标指导的技术，技术将被完全商业化为医疗设备大脑倡议中无创神经调节的目标。（1）我们将改善焦点当前交付具有新型靶向算法的深层和浅表脑位置（歧视性皮质来源矢量）以人头的高分辨率电导率模型实现。（2）模拟和实验将用于最大程度地减少非目标区域的外部刺激，同时量化电流交付给所有大脑区域。（3）我们将设计和测试安慰剂模式以允许确定的临床试验。（4）通过指导GTEN干预的本地化和阶段，可以实现闭环操作同时监测源元素的脑电图。在验证闭环操作时，脑电图将是慢波睡眠的人，并将假设它们在深度和长度上的增强夜晚的睡眠。完成此SBIR的目的将创建一个Deeg引导的无创的密集阵列电气神经调节技术是两项研究的强大，精确且廉价的技术和临床实践。