Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt University

范德比尔特大学尤尼斯·肯尼迪·施赖弗智力与发育障碍研究中心

• 批准号: 9275636
• 负责人: ELISABETH MAY DYKENS
• 金额: $ 39.76万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-17 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275636
• 关键词: Eunice; Kennedy; Shriver; Intellectual; Developmental

 DESCRIPTION (provided by applicant): This U54 application seeks renewed funding for Vanderbilt University's Intellectual and Developmental Disabilities Research Center (IDDRC), based in Vanderbilt's Kennedy Center. Vanderbilt's IDDRC includes the full range of basic, clinical, and intervention scientists necessary to fulfill the goals for the EKS NICHD IDDRC program of translational research that improves the lives of people with intellectual and developmental disabilities (IDD) and their families. Our IDDRC focuses on elucidating mechanisms and effective interventions for individuals with autism spectrum disorders, learning disabilities, genetic IDD syndromes, and acquired IDDs. Within each of these groups, IDDRC investigators discover underlying disease mechanisms, treatment targets, and aberrant developmental processes in model systems; assess cognitive, social, emotional, and neural phenotypes; and conduct innovative treatment and intervention studies. These activities are embodied in the U54 Research Project, Sensory and Multisensory Contributions to Autism, which meets the EKS NICHD Focus Theme #2: Outcome Measures for Interventions, and highlights an understudied but increasingly recognized characteristic of autism. Vanderbilt's U54 IDDRC includes 46 investigators from 15 academic departments who lead 69 research projects; 14 are funded by the EKS NICHD. We propose five exceptional, non-duplicative IDDRC Cores to support these investigators and that are also integrated into each Specific Aim of the U54 Research Project. The Administrative Core A provides scientific direction, manages IDDRC governance committees and activities, and leads innovative training and educational programs. Clinical Translational Core B meets investigators' immediate needs for recruiting and phenotyping participants with IDDs, while also assisting with clinical trials, mining novel epidemiological data for IDD phenotyping, and building a new resource of IDD outcome measures. Translational Neuroimaging Core C assists investigators with neuroimaging and psychophysiology data acquisition, processing, and analyses; creates novel experimental paradigms, and proposes "big data" approaches for large-scale investigations of IDD. Neuroscience Core D provides essential and inherently generative services in mouse neurobehavioral phenotyping, neurochemistry, molecular neurobiology and genomics, and scientific instrumentation, which designs, constructs, or repairs specialized research equipment. Biostatistics and Bioinformatics Core E improves research quality with expert biostatistical consultation and training on topics that are relevant to IDDs, and also develops unique bioinformatics databases of electronic medical record data from patients with IDDs that are linked to their DNA. IDDRC Cores are thus customized to meet the immediate needs of our investigators, and also to generate novel, forward-thinking technologies, tools, or resources that drive innovative discoveries aimed at understanding and ameliorating IDDs.

 描述（由申请人提供）：此 U54 申请为范德比尔特大学智力和发育障碍研究中心 (IDDRC) 寻求续期资助，该中心位于范德比尔特肯尼迪中心。范德比尔特 IDDRC 包括满足以下要求所需的全方位基础、临床和干预科学家。 EKS NICHD IDDRC 转化研究计划的目标是改善智力和发育障碍人士 (IDD) 及其家人的生活。我们的 IDDRC 致力于阐明自闭症谱系障碍、学习障碍、遗传性 IDD 综合征和获得性 IDD 患者的机制和有效干预措施，在这些群体中，IDDRC 调查人员发现模型系统中潜在的疾病机制、治疗目标和异常发育过程。评估认知、社交、情感和神经表型；并进行创新的治疗和干预研究，这些活动体现在符合 EKS 的 U54 研究项目“感觉和多感觉对自闭症的贡献”中。 NICHD 焦点主题#2：干预措施的结果，强调了自闭症的一个尚未得到充分研究但日益被认可的特征，范德堡大学 U54 IDDRC 包括来自 15 个学术部门的 46 名研究人员，他们领导了 69 个研究项目；我们提出了 5 个特殊项目。 、非重复的 IDDRC 核心来支持这些研究人员，并且也集成到 U54 研究项目的每个特定目标中。核心 A 提供科学指导，管理 IDDRC 治理委员会和活动，并领导创新培训和教育计划。核心 B 满足研究人员招募 IDD 参与者并对其进行表型分析的迫切需求，同时协助临床试验，挖掘新的流行病学数据。 IDD 表型分析，以及构建 IDD 结果测量的新资源，可协助研究人员进行神经影像和心理生理学数据采集、处理和分析，并提出新的实验范式；用于 IDD 大规模研究的“大数据”方法。神经科学核心 D 在小鼠神经行为表型、神经化学、分子神经生物学和基因组学以及科学仪器方面提供必要的、固有的生成服务，用于设计、构建或修复专业的生物统计学设备。生物信息学核心 E 通过专家生物统计咨询和 IDD 相关主题培训提高研究质量，并开发独特的电子病历数据生物信息学数据库因此，IDDRC 核心经过定制，可以满足我们研究人员的即时需求，并产生新颖的、前瞻性的技术、工具或资源，推动旨在理解和改善 IDD 的创新发现。