OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

儿童和青少年 MTBI 的结果测量

• 批准号: 8167301
• 负责人: GERARD A. GIOIA
• 金额: $ 0.05万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167301
• 关键词: 18 year old; Adolescent; Age; Alleles; Area; Back; Behavioral; Child; Childhood; Childhood Injury; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Education; Funding; Gene Frequency; Genes; Genetic; Genetic Polymorphism; Grant; Institution; Link; Measurement; Measures; Medical center; Neurocognitive; Outcome; Outcome Measure; Phase; Process; Protocols documentation; Psychometrics; Recovery; Research; Research Personnel; Resources; Sample Size; Sensitivity and Specificity; Short-Term Memory; Source; Testing; Traumatic Brain Injury; United States National Institutes of Health; Universities; Validation; interest; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 6-year-multi-center collaborative research study between Children's National Medical Center, the Department of Education-Kaua'i Complex Area, University of Pittsburgh Medical Center, A.T. Still University and Dartmouth Hitchcock Medical Center. The aim of Phase 1, which has already been completed, was the initial development and adaptation of the three principal tests of the mTBI battery for the pediatric age range (5-18 years) - ImPACT, the BRIEF, and the N-back working memory measure. The specific aim of Phase 2 is the psychometric development of the tests with the mTBI battery including norming, test-retest reliability, and concurrent validity across the 5-18 year age range. The specific aim of Phase 3 is clinical validation, i.e., to establish the sensitivity and specificity of the mTBI battery to detect neruocognitive and behavioral changes in children with mTBI.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尽管轻度的脑损伤（MTBI）是儿童最常见的伤害之一，但在MTBI后儿童的恢复过程和长期功能后遗症（包括遗传因素的影响），几乎没有进行系统性研究。将多态性等位基因与神经认知结果联系起来是确定某些基因是否有助于MTBI后恢复的一种策略。但是，等位基因多态性研究需要明确和验证的结果指标和适合感兴趣等位基因频率的样本量。该协议描述了第1阶段的试点阶段，是一项为期4期，6年的中心合作研究，匹兹堡大学医学中心，儿童国家医疗中心（儿童国家医疗中心）之间的儿童国家医疗中心之间的研究阶段。 Still University和Dartmouth Hitchcock医疗中心。已经完成的第1阶段的目的是针对小儿年龄范围（5-18岁）的MTBI电池的三个主要测试的初步开发和适应 - 影响，简介和N-BACK工作记忆测量。 第2阶段的具体目的是通过MTBI电池进行测试的心理测量发展，包括规范，测试可靠性和在5-18岁年龄段的同时有效性。第3阶段的具体目的是临床验证，即建立MTBI电池的敏感性和特异性，以检测MTBI儿童的神经认知和行为变化。