MECHANISMS OF SLEEP DISTURBANCE IN CHILDREN WITH GENERALIZED ANXIETY DISORDER (G

患有广泛性焦虑症（G）的儿童睡眠障碍的机制

• 批准号: 8167294
• 负责人: Candice A Alfano
• 金额: $ 0.15万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167294
• 关键词: Adult; Anxiety; Anxiety Disorders; Area; Arousal; Attention; Child; Chronic; Clinical Research; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Dimensions; Disease; Environmental Risk Factor; Failure; Funding; Generalized Anxiety Disorder; Grant; Impairment; Injury; Institution; Laboratories; Methods; Occupational; Parenting behavior; Patients; Prospective Studies; Recovery; Research; Research Personnel; Resources; Risk; Severities; Short-Term Memory; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Source; Symptoms; United States National Institutes of Health; base; emotion regulation; experience; functional disability; neurophysiology; psychologic; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Generalized Anxiety Disorder (GAD) is among the most common anxiety disorders in children and is associated with impairments in multiple areas of functioning including academic, occupational, social, familial, and psychological domains. In addition to chronic worry and somatic complaints, patients with GAD frequently experience insomnia (defined as difficulty initiating and/or maintaining sleep). Although well-recognized in up to 70% of adults with the disorder, only recently has research begun to examine the extent of sleep disturbance in children. Preliminary research conducted by the PI and consultants based on both subjective and objective assessment indicates that 90% children with GAD experience sleep problems (Alfano, Ginsburg & Kingery, 2007; Forbes et al., 2008). However, in the absence of controlled, prospective studies, the persistence and severity of these problems are unknown. In otherwise healthy children, persistent sleep disturbance is associated with functional impairment including academic failure (Kahn et al., 1989), deficits in working memory and attention (Bruni et al., 2005; Steenari et al., 2003), decreased emotion regulation (Leotta et al.,1997; Wolfson & Carskadon, 1998), and injury risk (Owens et al., 2005). The presence of persistent sleep disturbance among children with GAD may therefore compound existing impairments in daytime functioning, exacerbate anxiety symptoms, and result in lower recovery rates. The current study will use both naturalistic and laboratory-based methods of assessment to evaluate the persistence, severity and features of sleep disturbance in children with GAD, including relationships with anxiety symptoms and impairments in functioning. Shared and unique factors associated with sleep disturbance also will be investigated including neurophysiological and cognitive dimensions of pre-sleep arousal, and parenting and environmental factors. Findings from this study may serve to identify children at risk for the later development of insomnia and GAD, as well as specific targets for clinical research and practice.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 广泛性焦虑症 (GAD) 是儿童最常见的焦虑症之一，与学术、职业、社交、家庭和心理等多个功能领域的损害有关。除了长期忧虑和躯体症状外，广泛性焦虑症患者还经常出现失眠（定义为难以入睡和/或维持睡眠）。尽管高达 70% 的成年人患有这种疾病，但研究直到最近才开始检查儿童睡眠障碍的程度。 PI 和顾问根据主观和客观评估进行的初步研究表明，90% 的广泛性焦虑症儿童存在睡眠问题（Alfano、Ginsburg & Kingery，2007；Forbes 等，2008）。然而，由于缺乏对照、前瞻性研究，这些问题的持续性和严重性尚不清楚。在其他方面健康的儿童中，持续的睡眠障碍与功能障碍有关，包括学业失败（Kahn 等人，1989）、工作记忆和注意力缺陷（Bruni 等人，2005；Steenari 等人，2003）、情绪调节能力下降（Leotta 等人，1997 年；Wolfson 和 Carskadon，1998 年）和伤害风险（Owens 等人，2005 年）。因此，广泛性焦虑症儿童持续性睡眠障碍可能会加剧现有的日间功能障碍，加剧焦虑症状，并导致康复率降低。目前的研究将使用自然主义和基于实验室的评估方法来评估广泛性焦虑症儿童睡眠障碍的持续性、严重性和特征，包括与焦虑症状和功能障碍的关系。还将研究与睡眠障碍相关的共同和独特因素，包括睡前唤醒的神经生理学和认知维度，以及养育和环境因素。这项研究的结果可能有助于确定有可能患上失眠和广泛性焦虑症的儿童，以及临床研究和实践的具体目标。