Mechanisms of Sleep Disturbance in Children with Generalized Anxiety Disorder

广泛性焦虑症儿童睡眠障碍的机制

• 批准号: 7761669
• 负责人: Candice A Alfano
• 金额: $ 15.97万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7761669
• 关键词: Address; Adolescent; Adult; Aftercare; Anxiety; Anxiety Disorders; Area; Arousal; Attention; Behavior; Child; Childhood; Chronic; Clinical Research; Cognitive; Data; Development; Diagnostic; Dimensions; Disease; Environmental Risk Factor; Evaluation; Exhibits; Failure; Family; Fostering; Generalized Anxiety Disorder; Goals; Home environment; Hydrocortisone; Impairment; Injury; Intervention; Investigation; Knowledge; Laboratories; Matched Group; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Methods; Occupational; Parenting behavior; Patients; Polysomnography; Prevalence; Prospective Studies; Psychopathology; Recovery; Regulation; Relapse; Reporting; Research; Research Ethics; Research Personnel; Research Training; Risk; Risk-Taking; Salivary; Schools; Severities; Short-Term Memory; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Symptoms; Training; Translational Research; actigraphy; base; career development; childhood anxiety; clinically relevant; emotion regulation; experience; functional disability; programs; prospective; skills; social; success; teacher

DESCRIPTION (provided by applicant): This is the second resubmission of an application for a Mentored Patient-Oriented Research Career Development Award (K23) to support the academic career development of the applicant. The candidate's long term goal is to develop a program of clinically-relevant, translational research focused on examining the influence and modifiability of sleep disturbance in the course and treatment of childhood anxiety disorders. Previously, the applicant has conducted research focused on the development of anxiety disorders in children and adolescents, including the prevalence of sleep disturbance. This application proposes training that is necessary for the next step in this research program, including advanced training in pediatric sleep medicine, laboratory-based training in the use and interpretation of polysomnography, assessment of neurohormonal dimensions of arousal in anxious children, and further training in research ethics and methodology. The mentorship of a select group of senior investigators will foster the candidate's development in a promising new area of research integrating two distinct areas of investigation: sleep medicine and developmental psychopathology. Prior research indicates that more than 90% of children with Generalized Anxiety Disorder (GAD) experience problems initiating and/or maintaining sleep; rates that are similar or higher than those found among adults with the disorder. Because persistent sleep disturbance during childhood is independently associated with multiple impairments in functioning including academic failure, decreased emotion regulation, decrements in attention and reasoning skills, injury risk, and risk-taking behavior, sleep problems among children with GAD may compound existing impairments, exacerbate anxiety symptoms, and result in lower recovery and higher relapse rates. The proposed study will use rigorous methods of assessment to address two primary aims: 1) to evaluate the persistence, features and daytime sequelae of sleep disturbance in children with GAD compared to a group of matched controls based on a one-week prospective, at-home assessment; and 2) to identify specific factors associated with the presence of sleep problems among children with GAD related to neurophysiologic and cognitive dimensions of arousal, and parenting and environmental factors. The training and research outlined in this proposal will equip the candidate with a unique set of necessary skills to advance knowledge in this important and under-researched area. Over the long-term, data will inform the development of empirically-based interventions for children with both sleep and anxiety disorders.

描述（由申请人提供）：这是一个由受过指导的患者研究职业发展奖（K23）申请的第二次重新提交，以支持申请人的学术职业发展。候选人的长期目标是制定一项与临床相关的转化研究计划，重点是研究睡眠障碍在儿童焦虑症过程中的影响和修改性。 以前，申请人进行了研究，重点是儿童和青少年焦虑症的发展，包括睡眠障碍的流行。该申请提出了该研究计划下一步所必需的培训，包括小儿睡眠医学的高级培训，基于实验室的培训，用于使用和解释多个学术摄影的使用和解释，焦虑儿童唤醒的神经激素维度的评估以及进一步的研究伦理学培训和进一步的培训 方法论。精选的高级调查人员的指导将培养候选人的 在一个有希望的新研究领域的发展，整合了两个不同的调查领域：睡眠 医学与发育心理病理学。先前的研究表明，有90％以上的普遍焦虑症（GAD）经历了发起和/或维持睡眠的问题；比率相似或高于该疾病的成年人。因为儿童期间的持续性睡眠障碍与功能的多种障碍独立相关，包括学术失败，情绪调节和推理技能的降低，伤害风险和冒险行为，因此患有GAD的儿童的睡眠问题可能会使现有障碍的障碍加剧，加剧焦虑症状以及导致恢复较低的恢复和较低的复发率。拟议的研究将使用严格的评估方法来解决两个主要目的：1）与一组基于一周的前瞻性，在家评估的一组匹配的对照组相比，患有GAD儿童的持久性，特征和白天的睡眠障碍后遗症； 2）确定与唤醒的神经生理学和认知维度以及育儿和环境因素相关的GAD儿童的睡眠问题相关的特定因素。该提案中概述的培训和研究将使候选人拥有一套独特的必要技能，以提高在这个重要且研究不足的领域的知识。从长远来看，数据将为患有睡眠和焦虑症的儿童提供基于经验的干预措施的发展。