Training Program in Cardiovascular Research

心血管研究培训计划

基本信息

批准号：
8496847
负责人：
RICHARD H KARAS
金额：
$ 35.25万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8496847
关键词：
Cardiovascular system Research Training Programs

项目摘要

DESCRIPTION (provided by applicant): This is a competitive renewal application for a post-doctoral Cardiovascular Training Grant (CVTG) Program centered at Tufts Medical Center (Tufts-MC) and Tufts University School of Medicine (TUSM). This CVTG provides state-of-the-art training to outstanding postdoctoral M.D. and/or Ph.D. fellows and is exemplary of the approach that the NHLBI seeks for training the next generation of CV scientists. Two broad and overlapping types of mechanistic CV research are emphasized: (1) cellular and molecular investigations of the CV system; and (2) translational, clinical studies in CV medicine. In its first five-year cycle this CVTG Program has been highly successful with 20 trainees to date, 43 peer-reviewed articles published by trainees, and two CVTG graduates now with K-grant funding. Several integrated elements make this CVTG Program a highly unique, multidisciplinary training experience: the rich training environment of the Tufts Health Sciences Campus, which includes Tufts-MC, TUSM, the Tufts Sackler Graduate School of Biomedical Sciences and the Tufts Human Nutrition Research Center, the internationally recognized Molecular Cardiology Research Institute, a major CV research department at Tufts-MC with 17 Pis and ~100 people, and the Tufts-MC Cardiology Division, with a superb group of translational researchers; the extensive portfolio of NIH-funded CV research in CVTG faculty; new training resources from the recent CTSA award; and the world-class faculty, with highly evolved collaborative interactions especially in this CVTG Program. Additional important strengths of this revised CVTG application include: 1. a special emphasis on mentoring, with each trainee being mentored by a 3-member mentoring committee with expertise spanning basic, clinical, and translational approaches, 2. a strong commitment to recruitment of highly qualified minority trainees, and 3. the inclusion of a strong and broad core curriculum. Trainees and faculty are formally evaluated on an annual basis. This program trains 4 postdoctoral M.D. and/or Ph.D. fellows per year for three years (steady-state: 12 trainees/year), with the goal of producing independent cardiovascular scientists well-equipped to lead their own research programs.

描述（由申请人提供）：这是竞争性更新的申请，用于以塔夫茨医学中心（TUFTS-MC）和塔夫茨大学医学院（TUSM）为中心的博士后心血管培训补助金（CVTG）计划。该CVTG为未偿还的博士后医学博士和/或博士提供了最先进的培训。研究员，是NHLBI寻求培训下一代简历科学家的方法的典范。强调了两种广泛而重叠的机械CV研究类型：（1）CV系统的细胞和分子研究；（2）CV医学的转化，临床研究。在其第一个五年周期中，该CVTG计划迄今为止，有20名学员，43位由学员发表的同行评审文章以及两名CVTG毕业生，现在拥有K-Grant资助。几个综合元素使该CVTG计划成为一种高度独特的多学科培训经验：塔夫茨健康科学校园的丰富培训环境，包括塔夫特式MC，TUSM，TUSM，Tufts Sackler生物医学科学研究生院以及簇生的人类营养研究中心。以及Tufts-MC心脏病学部，拥有一群流行的转化研究人员； CVTG教师的NIH资助CV研究的广泛投资组合；最近获得CTSA奖的新培训资源；以及世界一流的教师，具有高度发展的协作互动，尤其是在这个CVTG计划中。该修订后的CVTG应用程序的其他重要优势包括：1。特别强调指导，每个受训者都由一个由三名成员的指导委员会指导，具有跨越基本，临床和翻译方法的专业知识，2。对高度合格的少数派学员的招聘的坚定承诺，以及3。包含强大而广泛的核心级别的课程。每年对学员和教职员工进行正式评估。该计划训练4个博士后医学博士和/或博士学位。每年三年的研究员（稳态：12名学员/年），目的是生产独立的心血管科学家，能够领导自己的研究计划。

项目成果

期刊论文数量（47）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Carotid artery stiffness, high-density lipoprotein cholesterol and inflammation in men with pre-hypertension.

DOI：
10.1038/jhh.2009.7
发表时间：
2009-09
期刊：
Journal of human hypertension
影响因子：
2.7
作者：
通讯作者：

Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas.

DOI：
10.1186/1471-2261-13-19
发表时间：
2013-03-15
期刊：
BMC cardiovascular disorders
影响因子：
2.1
作者：
Warner PJ;Al-Quthami A;Brooks EL;Kelley-Hedgepeth A;Patvardhan E;Kuvin JT;Heffernan KS;Huggins GS
通讯作者：
Huggins GS

Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy.

DOI：
10.1016/j.amjcard.2010.10.023
发表时间：
2011-02-15
期刊：
AMERICAN JOURNAL OF CARDIOLOGY
影响因子：
2.8
作者：
Heffernan, Kevin S.;Maron, Martin S.;Patvardhan, Eshan A.;Karas, Richard H.;Kuvin, Jeffrey T.
通讯作者：
Kuvin, Jeffrey T.

A Non-Perturbative Molecular Grafting Strategy for Stable and Potent Therapeutic Peptide Ligands.

DOI：
10.1021/acscentsci.0c01237
发表时间：
2021-03-24
期刊：
ACS central science
影响因子：
18.2
作者：
Sicinski KM;Montanari V;Raman VS;Doyle JR;Harwood BN;Song YC;Fagan MP;Rios M;Haines DR;Kopin AS;Beinborn M;Kumar K
通讯作者：
Kumar K

Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells.