Maternal and Child Health Benefits from Reducing Household Air Pollution

减少家庭空气污染对孕产妇和儿童健康有益

基本信息

批准号：
8519707
负责人：
Patricia L Hibberd
金额：
$ 65.19万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-03 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8519707
关键词：
Address Adverse effects Age Air Air Pollution Area Asia Attention Biological Biological Markers Biomass Birth Weight Carbon Monoxide Cessation of life Child Child health care Childhood Clinical Clinical Research Clinical Trials Commit Communicable Diseases Communities Cotinine Country Data Developing Countries Development Diarrhea Educational workshop Female First Pregnancy Trimester Foundations Funding Future Gases General Hospitals Goals Government Grant Growth Growth and Development function Guidelines Health Health Benefit Height Household Human Resources India Indoor Air Quality International Knowledge Lead Leadership Low Birth Weight Infant Massachusetts Maternal and Child Health Measures Medical Research Mentors Morbidity - disease rate National Institute of Child Health and Human Development Neonatal Neonatal Mortality Observational Study Outcome Particulate Matter Perinatal Perinatal mortality demographics Petroleum Pneumonia Policies Population Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Principal Investigator Process Protocols documentation Public Health Public Health Schools Quality of Care Randomized Clinical Trials Research Research Infrastructure Resources Risk Science Site Solid Tobacco smoke USAID Ultrasonography United States National Institutes of Health Ursidae Family Weight Woman World Health Organization abstracting base catalyst cooking evidence base experience falls implementation science improved infant outcome medical schools mortality neonatal sepsis pollutant primary outcome programs public health relevance randomized trial respiratory secondary outcome working group

项目摘要

DESCRIPTION (provided by applicant): The consortium between the Massachusetts General Hospital and the Indira Gandhi Government Medical College Nagpur, India, affiliated with Lata Medical Research Foundation, has extensive experience in conducting international multicenter collaborative clinical trials/implementation science research dedicated to improving maternal and child health. Since 2008, the consortium has participated as a Research Unit (RU) in the Global Network (GN) for Women's and Children's Health Research and is applying to continue the productive and successful RU in Nagpur, India. The RU's goal is to continue to develop and implement GN sponsored common protocols that generate evidence and scientific knowledge to sustainably improve outcomes for women and children. The research that the MGH-Nagpur consortium proposes to develop is based on their current GN studies on the adverse effects of Household Air Pollution (HAP) on pregnancy and infant outcomes. Their GN research is focused in this area because 3 billion people (~ half of the world's population) and -80% of pregnant women in the GN still use traditional cook stoves and solid fuels that generate high levels of household pollutants, far exceeding World Health Organization (WHO) indoor air quality guidelines. WHO estimates that HAP causes 2 million deaths annually (mostly in women and children). They propose to develop a multicenter randomized clinical trial to evaluate whether pregnancy and infant outcomes can be improved by introduction of cook stoves/fuel that reduce HAP in households where pregnant women, in their first trimester, are using traditional cook stoves. The primary outcome is birth weight. Secondary outcomes are preterm birth, perinatal/neonatal mortality, childhood pneumonia/neonatal sepsis and adverse child growth/development. They also propose to measure HAP levels in women and children in a random subset of households to improve knowledge about the biological basis of the effects of HAP - including particulate matter < 2.5 micrometers, carbon monoxide and biomarkers 1-hydroxypyrene, methoxyphenol and cotinine (tobacco smoke). Successful introduction of cook stoves/fuel that reduce HAP has the potential to sustainably improve pregnancy outcomes and child health in resource limited settings.

描述（由申请人提供）：与LATA医学研究基金会相关的印度纳格布尔的马萨诸塞州综合医院与英迪拉·甘地政府医学院之间的财团在进行国际多中心协作临床试验/实施科学研究方面具有丰富的经验，致力于改善母体和儿童健康。自2008年以来，该财团已在全球网络（GN）中担任研究部门（RU），以供妇女和儿童健康研究，并申请继续在印度那格浦尔的富有成效和成功的RU。 RU的目标是继续开发和实施GN赞助的共同协议，以产生证据和科学知识，以可持续改善妇女和儿童的预后。 MGH-NAGPUR联盟提议开发的研究基于他们目前关于家庭空气污染（HAP）对怀孕和婴儿结局的不利影响的研究。他们的GN研究集中在这一领域，因为GN中有30亿人（约占世界人口的一半）和-80％的孕妇仍使用传统的库克炉和固体燃料，这些炉灶和固体燃料产生了高水平的家庭污染物，远远超过了世界卫生组织（WHO）iniveror Air质量指南。谁估计HAP每年造成200万人死亡（主要是在妇女和儿童中）。他们建议开发一项多中心随机临床试验，以评估通过引入库克炉/燃料的引入孕妇使用传统库克炉的孕妇的家庭中的库克炉/燃料是否可以改善怀孕和婴儿结果。主要结果是出生体重。次要结果是早产，围产期/新生儿死亡率，儿童肺炎/新生儿败血症和儿童成长/发育不良。他们还建议在家庭中随机子集中衡量妇女和儿童的HAP水平，以提高有关HAP作用的生物学基础的知识 - 包括颗粒物<2.5微米，一氧化碳和生物标志物1-羟基氧基，甲氧基苯酚和cotinine和cotinine（烟草烟）。成功地引入了减少HAP的厨师炉子/燃料，有可能在资源有限的环境中可持续改善妊娠结局和儿童健康。