Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research Unit

波士顿大学/拉塔医学研究基金会全球妇女儿童健康网络研究单位

• 批准号: 10747708
• 负责人: Patricia L Hibberd
• 金额: $ 62.27万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747708
• 关键词: 3 year old; Address; Age; Agreement; Arabs; Area; Azithromycin; Boston; Caring; Cesarean section; Cessation of life; Child; Child Health; Childhood; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Country; Devices; Disabled Persons; Discipline of obstetrics; Disparity; Environmental Exposure; Exposure to; Faculty; Foundations; Goals; Government; Growth and Development function; Haplotypes; Health; Household Air Pollution; India; Infant Malnutrition; Infant Mortality; Infrastructure; Institution; Intervention; Lactation; Lead; Leadership; Live Birth; Medical; Medical Research; Mentors; Metagenomics; Mobile Health Application; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Neonatology; Newborn Infant; Observational Study; Outcome; Patients; Pediatric Research; Pediatrics; Population; Population Heterogeneity; Populations at Risk; Pregnancy; Pregnant Women; Productivity; Protocols documentation; Publications; Rationalization; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Resource-limited setting; Risk; Role; Schools; Science; Sickle Cell Anemia; Site; Slum; Socioeconomic Status; Strategic Planning; Students; Sustainable Development; Testing; Time; Tribes; Underserved Population; United Nations; Universities; Variant; Woman; adolescent health; adverse outcome; azithromycin resistance; clinical research site; cost effective; data access; data sharing; design; early childhood; fetal; genome sequencing; global health; improved; indexing; low and middle-income countries; maternal depression; maternal risk; medical schools; microbiome; mortality; novel; patient engagement; point-of-care diagnostics; pregnant; prepregnancy; public health intervention; public health research; recruit; reproductive; retention rate; therapeutically effective; whole genome

PROJECT SUMMARY Although there have been improvements in the under age five mortality rate (U5MR) and neonatal mortality rate (NMR) in Indian children, the burden of death in this population is still one live births to deaths. To achieve the United Nations Sustainable Development Goals for the U5MR and NMR rate, there is still an urgent need for improvement in pre-pregnancy through childhood care in India and globally. The overarching goal of Boston University (BU) and Lata Medical Research Foundation's (LMRF) Global Network (GN) for Women's and Children's Health Research Unit (RU) is to continue to collaborate with other GN RUs on research to improve health outcomes for women and children in low- and lower middle-income countries (LMIC). We have had a GN RU in Nagpur, India continuously since 2008. Our RU is in the eastern part of the State of Maharashtra (center of India) where NMR and infant mortality rates are higher than the overall rates in the state and many other parts of India. Our RU involves a partnership between multiple Schools and Departments (particularly Global Health, Obstetrics, Pediatrics, and Infectious Diseases) at Boston University and the academic medical institutional consortium led by the LMRF in Nagpur, that provides clinical, research expertise and infrastructure support. Since 2008, our RU has been successfully implementing studies, by patient and public involvement and engagement strategy, that exemplify Global Network's goals to conduct high-impact clinical trials and observational studies of sustainable, cost-effective health interventions and their implementation in women and children in LMICs, and building sustainable professional capacity and infrastructure for infectious diseases (maternal and pediatric), obstetric, neonatal and pediatric research. In the current cycle of the GN, we have participated in all common protocols, and have maintained high recruitment and retention rates. We have led 5 research initiatives, including developing a new socioeconomic status index, and studying the risk of maternal, fetal and neonatal adverse outcomes associated with exposure to household air pollution, Caesarian Section delivery and Maternal Depression. We have also had a leadership role in the Azithromycin trial sub-study on risk of acquiring Azithromycin resistance using novel microbiome, metagenomics and whole genome sequencing approaches, which required helping develop lab capacity in several GN sites. We have jointly and successfully mentored 20 junior faculty, fellows and students who have led site specific and GN wide publications. continue growth and development of the Nagpur RU, advance the research network in the region, and sustain the research infrastructure for the design and conduct of public health research in the Nagpur academic institutions; strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area by public and patient engagement; and continue to identify and address gaps in maternal and child research.

项目摘要 尽管五岁以下死亡率（U5MR）和新生儿死亡率有所改善 印度儿童的率（NMR），该人口的死亡负担仍然是死亡的一个活产。实现 联合国U5MR和NMR利率的可持续发展目标，仍然有迫切需要 通过印度和全球的儿童护理来改善怀孕的儿童护理。总体目标 波士顿大学（BU）和LATA医学研究基金会（LMRF）全球网络（GN） 儿童健康研究部（RU）将继续与其他GN RUS合作进行研究 改善中低收入国家（LMIC）的妇女和儿童的健康状况。我们有 自2008年以来一直在印度那格浦尔（Nagpur 马哈拉施特拉邦（印度中心），NMR和婴儿死亡率高于 州和印度许多其他地区。我们的RU涉及多个学校和部门之间的伙伴关系 （尤其是全球健康，妇产科，儿科和传染病）在波士顿大学和 由NAGPUR的LMRF领导的学术医疗机构财团，该财团提供临床，研究专业知识 和基础设施支持。自2008年以来，我们的RU一直由患者和 公众参与和参与策略，体现了全球网络进行高影响力的目标 可持续，具有成本效益的健康干预措施的临床试验和观察性研究 在LMIC中实施妇女和儿童，并建立可持续的专业能力和 传染病（母亲和小儿），产科，新生儿和小儿研究的基础设施。在 GN的当前周期，我们参与了所有共同协议，并保持了高招聘 和保留率。我们领导了5项研究计划，包括建立新的社会经济地位 索引，研究与暴露有关的产妇，胎儿和新生儿不利结果的风险 家庭空气污染，凯撒分段的分娩和孕产妇抑郁症。我们也有领导 在阿奇霉素试验中的作用在使用新型微生物组获得阿奇霉素耐药性的风险中， 宏基因组学和整个基因组测序方法，这需要帮助发展实验室能力 几个GN站点。我们已经共同指导了20名初级教师，研究员和有 LED网站特定和GN广泛的出版物。继续增长和发展纳格布尔Ru，促进 该地区的研究网络，并维持公众设计和行为的研究基础设施 那格浦尔学术机构的健康研究；加强研究的重点是 公众和NAGPUR地区的怀孕和幼儿期的发病率和死亡率由公众和 患者参与；并继续识别和解决孕产妇研究中的差距。

项目成果

Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India.

• DOI: 10.3390/ijerph18010183
• 发表时间: 2020-12-29
• 期刊: International journal of environmental research and public health
• 作者: Parikh R;Rao SR;Kukde R;O'Connor GT;Patel A;Hibberd PL
• 通讯作者: Hibberd PL

Detection and risk stratification of women at high risk of preterm birth in rural communities near Nagpur, India.

• DOI: 10.1186/s12884-017-1504-4
• 发表时间: 2017-09-19
• 期刊: BMC pregnancy and childbirth
• 影响因子: 3.1
• 作者: Patel A;Prakash AA;Pusdekar YV;Kulkarni H;Hibberd P
• 通讯作者: Hibberd P

Gender variations in neonatal and early infant mortality in India and Pakistan: a secondary analysis from the Global Network Maternal Newborn Health Registry.

• DOI: 10.1186/s12978-020-01028-0
• 发表时间: 2020-12-17
• 期刊: Reproductive health
• 影响因子: 3.4
• 作者: Aghai ZH;Goudar SS;Patel A;Saleem S;Dhaded SM;Kavi A;Lalakia P;Naqvi F;Hibberd PL;McClure EM;Nolen TL;Iyer P;Goldenberg RL;Derman RJ
• 通讯作者: Derman RJ

Early Identification of Preterm Neonates at Birth With a Tablet App for the Simplified Gestational Age Score (T-SGAS) When Ultrasound Gestational Age Dating Is Unavailable: Protocol for a Validation Study.

当超声孕龄测定不可用时，使用平板电脑应用程序进行简化孕龄评分 (T-SGAS) 早期识别早产新生儿：验证研究方案。

• DOI: 10.2196/11913
• 发表时间: 2019
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Patel,ArchanaB;Kurhe,Kunal;Prakash,Amber;Bhargav,Savita;Parepalli,Suchita;Fogleman,ElizabethV;Moore,JanetL;Wallace,DennisD;Kulkarni,Hemant;Hibberd,PatriciaL
• 通讯作者: Hibberd,PatriciaL

Early identification of preterm neonates at birth with a Tablet App for the Simplified Gestational Age Score (T-SGAS) when ultrasound gestational age dating is unavailable: A validation study.

当超声孕龄测定不可用时，使用平板电脑应用程序进行简化孕龄评分 (T-SGAS) 早期识别早产儿：一项验证研究。

• DOI: 10.1371/journal.pone.0238315
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Patel,ArchanaB;Kulkarni,Hemant;Kurhe,Kunal;Prakash,Amber;Bhargav,Savita;Parepalli,Suchita;Fogleman,ElizabethV;Moore,JanetL;Wallace,DennisD;Hibberd,PatriciaL
• 通讯作者: Hibberd,PatriciaL