MicroRNA Regulation Of Cell Survival In Angiogenesis & Vessel Maturation

血管生成中细胞存活的 MicroRNA 调节

基本信息

批准号：
8472527
负责人：
Sudarshan Anand
金额：
$ 9.79万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2014-03-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8472527
关键词：
Address Affect Angiogenic Factor Apoptosis Apoptotic Attenuated Blood Vessels Cell Death Cell Proliferation Cell Survival Cell physiology Cells Complex Development Disease Endothelial Cells Equilibrium Functional RNA Genome Growth Growth Factor Hemangioma Human In Vitro Inflammation Laboratories Macular degeneration Malignant Neoplasms Mediating Mediator of activation protein Medicine Mentors MicroRNAs Modeling Nature Neonatal Neoplasms in Vascular Tissue Notch Signaling Pathway Pathologic Neovascularization Pathology Pathway interactions Pattern Phase Physiological Processes Process Regulation Research Rest Retinal Diseases Retinal Hemangioma Role Signal Transduction Small RNA Smooth Muscle Myocytes Starvation Stem cells Stimulus Strawberry nevus Stress Tissues Training Tumor Suppressor Genes Work Xenograft Model angiogenesis biological adaptation to stress human disease in vivo malformation mouse model notch protein p120 GTPase Activating Protein postnatal programs response retinal angiogenesis

项目摘要

DESCRIPTION (provided by applicant): Aberrant growth of blood vessels termed 'angiogenesis' contributes to the pathology of several human diseases ranging from macular degeneration, retinopathy to inflammation and cancer. Recently small RNAs encoded in the genome termed microRNAs have been implicated in the regulation of diverse physiological processes including angiogenesis. We recently profiled microRNAs during activation of endothelial cells and identified microRNA-132 as a critical regulator of p120RasGAP during pathological neovascularization. In this proposal, I will characterize the role of miR-132/p120RasGAP in cell survival during stress responses in the vasculature using in vitro and in vivo angiogenesis models during the mentored phase. Using these models, in the independent phase, I will analyze the contribution of a different microRNA that functions as a negative regulator of cell survival in vascular cells. These studies will elucidate how distinct microRNA programs govern the balance between the pro and anti-angiogenic states in the vasculature during development and disease.

描述（由申请人提供）：称为“血管生成”的血管的异常生长有助于几种人类疾病的病理学，从黄斑变性，视网膜病到炎症和癌症。最近在称为microRNA的基因组中编码的小RNA与包括血管生成在内的多种生理过程有关。我们最近在激活内皮细胞的过程中介绍了microRNA，并将MicroRNA-132鉴定为病理新生血管化期间P120RASGAP的关键调节剂。在此提案中，我将在荷兰阶段使用体外和体内血管生成模型在脉管系统的应力反应中MiR-132/P120RASGAP在细胞存活中的作用。使用这些模型，在独立阶段，我将分析不同的microRNA的贡献，该microRNA充当血管细胞中细胞存活的负调节剂。这些研究将阐明不同的microRNA计划如何控制发育和疾病期间脉管系统中抗血管生成状态之间的平衡。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Emerging Role of Micro-RNAs in the Regulation of Angiogenesis.

DOI：
10.1177/1947601911423032
发表时间：
2011-12-01
期刊：
Genes & cancer
影响因子：
0
作者：
Anand, Sudarshan;Cheresh, David A
通讯作者：
Cheresh, David A

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling.

DOI：
10.1038/s41419-018-0690-y
发表时间：
2018-05-24
期刊：
Cell death & disease
影响因子：
9
作者：
Espinosa-Diez C;Wilson R;Chatterjee N;Hudson C;Ruhl R;Hipfinger C;Helms E;Khan OF;Anderson DG;Anand S
通讯作者：
Anand S

A brief primer on microRNAs and their roles in angiogenesis.