Influence of subglottic anatomy on voice production

声门下解剖结构对发声的影响

• 批准号: 8492057
• 负责人: Jonathan J. Wisco
• 金额: $ 29.01万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8492057
• 关键词: Acoustics; Adult; Affect; Aftercare; Anatomy; Area; Caring; Characteristics; Computer Simulation; Connective Tissue; Coupling; Data; Excision; Experimental Models; Female; Frequencies; Goals; Healed; Image; Imagery; Intervention; Larynx; Lead; Life; Measures; Mechanics; Medical; Modeling; Motion; Motivation; Muscle; Operative Surgical Procedures; Outcome; Paralysed; Patients; Phonation; Positioning Attribute; Postoperative Period; Procedures; Production; Prostheses and Implants; Research; Research Personnel; Resolution; Role; Simulate; Slice; Source; Speech; Stenosis; Stress; Subglottis structure; Testing; Tissues; Voice; Voice Disorders; Voice Quality; X-Ray Computed Tomography; clinical care; conditioning; design; glottis; healing; improved; male; model development; models and simulation; physical model; pressure; reconstruction; repository; research study; routine care; sound frequency; vibration; virtual; vocal cord

PROJECT SUMMARY Vocal fold vibration is caused by a three-way coupling between laryngeal aerodynamics, acoustics, and tissue dynamics. Research focused on the glottic and supraglottic laryngeal regions has led to improved clinical care and medical procedures. Less understood is the role of the subglottic region in vocal fold vibration. However, the subglottis is an important part of speech production. A clear understanding of the geometry and mechanics of the subglottis will show how vocal fold vibration is affected by adverse conditions, such as subglottic stenosis, and corresponding phonosurgical treatment procedures. The goal of the proposed research is to acquire an improved understanding of the role of subglottic anatomy in voice production. This will result from pursuit of the following specific aims: Aim 1: Quantify three-dimensional adult human larynx geometry for use in voice production research. High- resolution, spatially calibrated images of adult human larynges will be collected from computed tomography (CT) and histological image sequences. Micro-CT and histological images will be obtained using excised larynges. These will be used to quantify macroscale glottic and subglottic geometric definitions, including vocal folds, cartilaginous framework, muscles, and connective tissue. The data will be made freely available to other researchers through an on-line repository. Aim 2: Explore the influence of subglottic anatomy on structural, acoustic, and aerodynamic aspects of phonation using complementary synthetic and computational models. Geometric data from Aim 1 will be used to create synthetic and computational self-oscillating laryngeal models, including glottic and subglottic regions. Models with changes in subglottic geometry and composition will be created, tested, and compared with original models. Observables include structural, acoustic, and aerodynamic data. Aim 3: Simulate the results of phonosurgical intervention through computational and synthetic model reconstruction. Patients with subglottic stenosis have CT imaging studies of the larynx available as part of their routine care. Before and after phonosurgical procedure of cricotracheal sleeve resection, the larynx will again be imaged. The images will be used for computational and synthetic model simulation and analysis. The results will be compared with preoperative and postoperative acoustic, aerodynamic, and laryngeal imaging measures. Adjustments to improve phonation will be tested using the computational and physical models. Accomplishing the above aims will impact several areas of voice care and research, including surgical treatment of voice disorders, vocal fold prosthesis and implant design, and voice production research.

项目摘要 声带振动是由喉空气动力学，声学和组织之间的三向耦合引起的 动力学。研究重点是发光和喉部喉部区域的研究导致了改善的临床护理 和医疗程序。不了解的是次声门区域在声带振动中的作用。然而， subglottis是语音生产的重要组成部分。对几何学和力学的清晰了解 subglottis的声音折叠振动如何受到不利条件的影响，例如sublottic 狭窄和相应的语音治疗程序。拟议研究的目的是 对亚平底解剖学在语音生产中的作用有了深入的了解。这将是由 追求以下特定目标： 目标1：量化用于语音生产研究的三维成年人喉几何形状。高的- 将从计算机断层扫描中收集分辨率的，空间校准的成年人喉的图像 （CT）和组织学图像序列。使用切除 喉。这些将用于量化宏观的镜头和次声学几何定义，包括人声 褶皱，软骨框架，肌肉和结缔组织。数据将免费提供给其他 研究人员通过在线存储库。 AIM 2：探讨亚平面解剖学对结构，声学和空气动力学方面的影响 使用互补的合成和计算模型发声。 AIM 1的几何数据将使用 创建合成和计算自我振荡的喉模型，包括震颤和次化区域。 将创建，测试并进行比较的模型，并将其构成变化。 原始型号。可观察的内容包括结构，声学和空气动力学数据。 AIM 3：通过计算和合成模型模拟语音干预的结果 重建。次变狭窄的患者对喉部的CT成像研究作为其喉部的一部分。 常规护理。骨气阀套筒切除后和之后，喉部将再次 成像。这些图像将用于计算和合成模型仿真和分析。这 结果将与术前和术后声学，空气动力学和喉成像进行比较 措施。调整以改进发声将使用计算和物理模型进行测试。 完成上述目标将影响语音护理和研究的几个领域，包括手术 语音障碍，声带假体和植入物设计以及语音生产研究的处理。