Resource for Quantitative Functional MRI

定量功能 MRI 资源

• 批准号: 8537457
• 负责人: Peter CM Van Zijl
• 金额: $ 129.33万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8537457
• 关键词: Anatomy; Attention; Automobile Driving; Biological Markers; Biomedical Research; Brain; Brain imaging; Child; Clinic; Coiled Bodies; Collaborations; Communities; Data; Development; Disease; Elderly; Environment; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Hospitals; Human; Image; Inherited; Instruction; Laboratories; Learning Disabilities; Longevity; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Maryland; Measurement; Mental disorders; Metabolic Diseases; Metabolism; Methodology; Modality; Multiple Sclerosis; Nerve Degeneration; Neurodegenerative Disorders; Physiological; Physiology; Process; Recording of previous events; Research; Research Infrastructure; Research Institute; Resources; Schizophrenia; Science; Services; Structure; Supercomputing; System; Technology; Tissues; Training; Translating; United States National Institutes of Health; Universities; Vertebral column; computerized data processing; data acquisition; design; image processing; improved; investigator training; method development; nervous system disorder; new technology; novel; research and development; supercomputer

The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary laboratory combining facilities of the F.M. Kirby Research Center for Functional Brain Imaging at the Hugo Moser Research Institute at Kennedy Krieger (KKI) and the Center for Imaging Science (CIS) at Johns Hopkins University (JHU). This Resource Center is dedicated to using its unique expertise to design novel MRI and MRS data acquisition and processing technology in order to facilitate the biomedical research of a large community of clinicians and neuroscientists in Maryland and throughout the USA, with a special focus on brain development, i.e. the changing brain throughout our life span. These NIH-funded driving biomedical projects have a continued need for the development of new quantitative technology to better achieve the aims in their grants, which focus on topics such as learning disabilities, impaired brain development, inherited metabolic disorders, attention deficit, neurodegeneration, multiple sclerosis, schizophrenia, and cancer. The Kirby Center has 3T and 7T state of the art scanners equipped with parallel imaging capabilities (8, 16, and 32-channel receive coils), and a dual transmit body coil at 3T. The 7T is to be extended with a 8-channel multi-transmit system. CIS has an IBM supercomputer that is part of a national supercomputing infrastructure. Our Resource combines a strong technical environment with unique expertise of the collaborators in our driving biomedical projects, who are continuously asking questions to improve technology for their studies in children, the elderly, and subjects with neurological and psychiatric disorders. These needs are reflected in the proposed developments in our technical research and development (TR&D) projects that focus on MRI and MR spectroscopy (MRS) assessment of tissue changes in metabolite levels, structure, physiology, and brain functioning when the brain is changing size during development. The resource provides training in these new acquisition and processing technologies and has a longstanding history of disseminating them to other research centers and hospitals.

定量功能磁共振成像资源是跨部门和 跨学科实验室结合了 F.M. 的设施柯比功能脑研究中心 肯尼迪克里格雨果莫泽研究所 (KKI) 和成像科学中心的成像 约翰霍普金斯大学（JHU）（CIS）。该资源中心致力于利用其独特的专业知识 设计新颖的MRI和MRS数据采集和处理技术，以促进生物医学 马里兰州和整个美国的一个由临床医生和神经科学家组成的大型社区的研究， 特别关注大脑发育，即大脑在我们一生中不断变化的情况。这些由 NIH 资助的 推动生物医学项目持续需要开发新的定量技术 更好地实现其赠款的目标，重点关注学习障碍、大脑受损等主题 发育、遗传性代谢紊乱、注意力缺陷、神经退行性疾病、多发性硬化症、 精神分裂症和癌症。卡比中心拥有 3T 和 7T 最先进的扫描仪，配备并行 成像功能（8、16 和 32 通道接收线圈）以及 3T 的双发射体线圈。 7T是为了 可通过 8 通道多传输系统进行扩展。 CIS 拥有一台 IBM 超级计算机，属于国家 超级计算基础设施。 我们的资源结合了强大的技术环境和合作者的独特专业知识 我们推动生物医学项目，他们不断提出问题以改进他们的技术 针对儿童、老年人以及患有神经和精神疾病的受试者的研究。这些需求是 反映在我们的技术研发 (TR&D) 项目的拟议发展中 重点关注 MRI 和 MR 波谱 (MRS) 评估组织代谢水平、结构、 当大脑在发育过程中改变大小时，生理学和大脑功能。资源 提供这些新的采集和处理技术的培训，并拥有悠久的历史 将它们传播到其他研究中心和医院。