3D Single Fiber Endoscope for Minimally Invasive Surgeries

用于微创手术的 3D 单纤维内窥镜

基本信息

批准号：
8574496
负责人：
Jason Geng
金额：
$ 14.81万
依托单位：
XIGEN, LLC
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8574496
关键词：
Abdomen Affect Algorithms Area Balloon Angioplasty Caliber Cardiology Client satisfaction Clinical Clinical Research Collaborations Color Computational Science Computer software Confined Spaces Data Decision Making Development Devices Diagnosis Diagnostic Economics Endoscopes Endoscopy Engineering Family suidae Fiber Goals Health system Hip Joint Housing Human Image In Vitro Intervention Knee Labyrinth Lasers Lead Light Location Lung Magnetic Resonance Imaging Malignant Neoplasms Measurement Mechanics Medical Methods Nose Operative Surgical Procedures Ophthalmologic Surgical Procedures Optic Nerve Optics Oral cavity Otolaryngology Patient Care Pharmaceutical Preparations Phase Positioning Attribute Postoperative Pain Procedures Process Recording of previous events Recovery Rectum Research Research Personnel Resolution Risk Scanning Shoulder Signal Transduction Sinus Site Skin Small Business Innovation Research Grant Solutions Spottings Study Section Surface Surgical incisions System Technology Testing Three-Dimensional Image Three-Dimensional Imaging Time Tissues Tooth structure United States National Institutes of Health Universities University Hospitals Washington Work base cost design experience flexibility image guided intervention innovation instrument middle ear minimally invasive novel prevent prototype public health relevance repaired research study response sensor skull base tool two-dimensional visual feedback

项目摘要

DESCRIPTION (provided by applicant): The primary objective of this SBIR effort is to develop a novel ultrathin (1~2 mm in diameter) scanning fiber endoscope (SFE) with simultaneous 2D/3D surface imaging capability. The proposed 3D-SFE will be able to provide, for the first time, dense 3D XYZ surface data that is co-registered with its 2D RGB counterpart, making 3D imaging an inherent part of SFE imaging capability without requiring users to perform any special manipulations or to take multiple images. The novel 3D imaging capability would greatly enhance the functionality of the existing SFE and enable it to perform, with its miniature probe size of 1~2 mm in diameter, a broad range of minimally invasive surgery procedures that were previously impossible to do. Unique features of the proposed novel 3D-SFE are: 7 High resolution full color 2D video image; 7 Unprecedented 3D imaging capability, with simultaneous and co-registered 2D and 3D image acquisition, possibly at video rate; 7 Single fiber scanner to generate stereo 3D images. 7 Dynamically adjustable field of view and image resolution; 7 Miniature size of the endoscope (~1 mm in diameter); 7 Extreme flexibility; and 7 Powerful 2D/3D image processing capability for minimally invasive surgeries. Xigen LLC proposes this comprehensive SBIR project, based on our strong collaborations and partnership with leading researchers/clinicians in multiple universities and hospitals. The Xigen team has long history and proven experience of attacking significant yet difficult 3D imaging problems in biomedical applications. Working closely with the research and clinical teams at the University of Washington who have developed multiple versions of working 2D scanning fiber endoscopes, we will develop full scale design, algorithms, hardware, software, and packaging for the 3D-SFE system, making it an integrated endoscopic image-guided system for minimally invasive surgeries that can access many sites that is currently impossible for existing endoscopes to do due to its ultra-thin diameter. This SBIR support will support thorough optical design, opto-electro-mechanical engineering development, 3D algorithmic development, and extensive tests. In Phase 1, the feasibility of the novel 3D-SFE will be thoroughly investigated. In Phase 2, working closely with clinical experts on our team, we will develop two fully functional 3D-SFE systems. We have streamlined our clinical study plan and focused on using 3D surface imaging capability for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves. Proprietary Information of XIGEN LLC. 0 NIH SBIR PAR-09-220

描述（由申请人提供）：SBIR工作的主要目的是开发具有同时2D/3D表面成像能力的新型超薄（直径为1〜2 mm）扫描纤维内窥镜（SFE）。拟议的3D-SFE将能够首次提供与其2D RGB对应物共同注册的密集的3D XYZ表面数据，这使得3D成像成为SFE成像能力的固有部分，而无需用户执行任何特殊的操作或拍摄多个图像。新颖的3D成像能力将大大提高现有SFE的功能，并使其直径为1〜2 mm的微型探针大小，这是一系列以前无法执行的微创手术程序。拟议的小说3D-SFE的独特功能是：7个高分辨率全彩2D视频图像； 7前所未有的3D成像能力，具有同时且共同注册的2D和3D图像采集，可能会以视频速率； 7单光纤扫描仪生成立体声3D图像。 7动态可调节的视野和图像分辨率； 7内窥镜的微型尺寸（直径约1毫米）； 7极度灵活性；和7强功能的2D/3D图像处理能力，可用于微创手术。 Xigen LLC根据我们与多个大学和医院的主要研究人员/临床医生的合作以及与领先的研究人员/临床医生的合作，提出了这个全面的SBIR项目。 Xigen团队在生物医学应用中攻击重大而困难的3D成像问题的历史和经验丰富的经验。与华盛顿大学的研究和临床团队紧密合作，这些研究和临床团队已经开发了多个版本的2D扫描光纤内窥镜，我们将为3D-SFE系统开发全尺度设计，算法，硬件，软件和包装，使其成为一种用于微创手术的集成内窥镜图像引导系统，这些系统可以访问许多由于其超薄直径而无法实现现有内窥镜的许多站点。这种SBIR支持将支持彻底的光学设计，光电机械工程开发，3D算法开发和广泛的测试。在第1阶段，将彻底研究新颖的3D-SFE的可行性。在第二阶段，与团队的临床专家紧密合作，我们将开发两个功能齐全的3D-SFE系统。我们已经简化了临床研究计划，并着重于使用3D表面成像能力进行微创手术，例如耳鼻喉科手术（访问窦，中耳，内耳和基于颅骨的手术），以及眼部手术和眼睛手术和药物对光学神经。 Xigen LLC的专有信息。 0 NIH SBIR PAR-09-220