Rocky Mountain Neurological Disorders Core

落基山神经疾病核心

基本信息

批准号：
8427299
负责人：
Angeles Badell Ribera
金额：
$ 4.06万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8427299
关键词：
Animal Model Animals Appointment Area Award Basic Science Behavioral Biochemistry Biological Models Biophysics Clinical Collaborations Colorado Core Facility Developmental Cell Biology Disease Electron Microscopy Epilepsy Faculty Fluorescence Fostering Funding Gene Targeting Generations Genetic Goals Ice Individual Instruction Laboratories Measurement Medical Microbiology Microscopy Molecular Mus Names National Institute of Neurological Disorders and Stroke Neurobiology Neurosciences Neurosciences Research Pediatric Neurology Pharmacologic Substance Pharmacology Pharmacy Schools Phenotype Physiology Positioning Attribute Rattus Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Rodent Science Secure Seizures Services Techniques Transgenic Mice Transgenic Organisms Translational Research Universities Ursidae Family Viral Viral Vector Zebrafish base design and construction experience interest light microscopy medical schools meetings molecular imaging nervous system disorder positional cloning professor programs synaptic function translational neuroscience translational study vector

项目摘要

PROJECT SUMMARY (See instructions): This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) \N\\\ design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core C Zebrafish Transgenic Core (Angeles Ribera, Director)m\\ provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.

项目摘要（请参阅说明）：这是对落基山神经障碍中心（RMNOC）的竞争更新，其主要目标是增强和进一步研究Ninos针对的神经生物学领域。 RMNO中心核心建立了设施，允许有效地生成和使用遗传变化的动物，这些动物表现出有趣且信息丰富的功能或行为表型。我们现有的核心都非常成功并发展为实现最先进的方法，从而使用户能够有效地进行协作研究。因此，我们建议将原始核心保持原始名称，并强调它们将在未来五年内继续发展，如应用程序中所述（核A，6，C和0）。和以前一样，这四个核心提供的服务在Anschutz的其他地方无法获得医疗校园。我们为RMNO Center Core提出了四个核心设施：核心A显微镜核心（Bill Betz，董事）将提供高级的轻型和电子显微镜服务。核心B基因靶向/病毒载体核心（主管Mark Dell'acqua）\ n \\\设计和构造向量，以生成靶向基因的和转基因小鼠以及病毒靶向向量。核心C斑马鱼转基因核心（Angeles Ribera，董事）M \\提供了维护和表征转基因斑马的服务。核心D机械车间核心（Ulli Bayer，董事）将提供机械车间的支持服务。