Rocky Mountain Neurological Disorders Core Center

落基山神经疾病核心中心

• 批准号: 7084558
• 负责人: Angeles Badell Ribera
• 金额: $ 71.3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7084558
• 关键词: biomedical facility; fluorescent dye /probe; nervous system disorder; zebrafish

DESCRIPTION (provided by applicant): This application requests funding for the Rocky Mountain Neurological Disorders Core Center, a facility with the aim of providing services for NINDS-funded investigators at UCHSC focused on the use of protein fluorescent indicators in vivo in mice and zebrafish. The combination of animal model systems and modern microscopy techniques is expected to result in a core center that will catalyze exciting new collaborative research projects within a group of already outstanding investigators. The facility will be directed by Dr. Angeles Ribera who will be assisted by a steering committee made up of the Directors of each core. Core usage will be prioritized as a function of previous usage of the core by each investigator. The facility will be housed in brand new space in the new Fitzsimons campus of the UCHSC. The following are the individual cores: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) will design and construct vectors to generate gone-targeted and transgenic mice as well as viral targeting vectors. Core C Zebrafish Transgenic Core (Angeles Ribera, Director) will provide services for the generation and maintenance of transgenic zebrafish. Core D Machine Shop (John Caldwell, Director) will provide machine shop and computer services.

描述（由申请人提供）： 该应用程序要求为落基山神经疾病核心中心提供资金，该设施的目的是为UCHSC的Ninds资助的研究人员提供服务，重点是在小鼠和斑马鱼中使用蛋白质荧光指标。预计动物模型系统和现代显微镜技术的结合将导致一个核心中心，该中心将催化一群已经出色的研究人员中令人兴奋的新合作研究项目。该设施将由安吉尔斯·里贝拉（Angeles Ribera）博士执导，他将由每个核心董事组成的指导委员会协助。每个研究者将优先考虑核心用法作为先前使用核心的函数。该设施将安置在UCHSC的新Fitzsimons校园的全新空间中。以下是各个核心：核心A显微镜核心（Bill Betz，Director）将提供高级的光和电子显微镜服务。核心B基因靶向/病毒矢量核心（主管Mark Dell'acqua）将设计和构建向量，以生成靶向和转基因小鼠以及病毒靶向向量。核心斑马鱼转基因核心（主任安吉尔斯·里贝拉（Angeles Ribera）将为转基因斑马鱼的生成和维护提供服务。 Core D机械车间（主任John Caldwell）将提供机械车间和计算机服务。