Experience-dependent plasticity of synaptic structure.

突触结构的经验依赖性可塑性。

基本信息

批准号：
8676596
负责人：
WENBIAO GAN
金额：
$ 38.59万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-11 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8676596
关键词：
Adult Animals Behavior Behavioral Brain Cerebral cortex Dendritic Spines Development Electroporation Excitatory Synapse Exhibits Fragile X Syndrome Genetic Growth Image Imaging Techniques Impaired cognition Impairment Individual Information Storage Label Learning Life Link Mental Retardation Microscopy Morphology Mus Mutant Strains Mice Neurodevelopmental Disorder Neurons Performance Pharmaceutical Preparations Phase Plastics Play Proteins Pyramidal Cells Regulation Rett Syndrome Role Sensory Sensory Deprivation Shapes Staging Structure Synapses Synaptic plasticity Techniques Testing Time Transgenic Mice Vertebral column base cell type density experience hippocampal pyramidal neuron in utero in vivo insight motor learning motor skill learning mouse model neural circuit novel novel strategies postnatal postsynaptic research study response sensory cortex sensory stimulus skills treatment strategy two-photon young adult

项目摘要

The aim of this proposal is to study the developmental regulation of dendritic spine plasticity and the role of experience in modifying synaptic connections in postnatal life. Using an in vivo transcranial two-photon imaging technique, changes of individual dendritic spines will be followed over extended periods of time in different cell types and in diverse cortical regions. We will determine how and to what degree sensory experience and learning modulate dendritic spine plasticity in the developing and adult cortex. Furthermore, we will investigate whether experience-dependent spine plasticity is compromised in mouse models of Fragile X syndrome and Rett syndrome and if so, whether drug treatment can restore experience-dependent spine plasticity in mutant mice. Together, these studies will provide fundamental insights into how experience and genetic factors shape neural circuits at different stages of life and suggest new strategies for the treatment of mental retardation.

该提案的目的是研究树突棘可塑性的发育调节以及经验在改变出生后突触连接中的作用。使用体内经颅双光子成像技术，将在较长时间内跟踪不同细胞类型和不同皮质区域中个体树突棘的变化。我们将确定感官体验和学习如何以及在多大程度上调节发育中和成人皮层的树突棘可塑性。此外，我们将研究脆性 X 综合征和雷特综合征小鼠模型中经验依赖性脊柱可塑性是否受到损害，如果是的话，药物治疗是否可以恢复突变小鼠中经验依赖性脊柱可塑性。总之，这些研究将为经验和遗传因素如何在生命的不同阶段塑造神经回路提供基本见解，并提出治疗精神发育迟滞的新策略。