Statistics, Epidemiology, and Data Management Core

统计、流行病学和数据管理核心

• 批准号: 8550987
• 负责人: BRUCE LEVIN
• 金额: $ 2.66万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550987
• 关键词: AIDS/HIV problem; Behavior; Behavior Therapy; Behavioral; Behavioral Sciences; Chairperson; Clinical; Clinical Trials Data Monitoring Committees; Communities; Data; Data Analyses; Data Base Management; Data Quality; Developing Countries; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Epidemiology; Faculty; Fostering; Future; Goals; Grant; HIV; HIV Infections; Individual; Infectious Disease Epidemiology; Intervention Studies; Joints; Leadership; Marshal; Methods; Mission; Observational Study; Online Systems; Performance; Positioning Attribute; Preparation; Prevention; Production; Productivity; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Risk; Role; Science; Solutions; Specialist; Staging; Structure; Technology; comparative; data management; design; epidemiologic data; experience; high standard; improved; innovation; instrumentation; meetings; member; multi-site trial; randomized trial; relational database; response; skills; statistics; transmission process

The Statistics, Epidemiology, and Data Management Core (SED) will advance HIV research and improve the quality of proposals submitted by HIV Center-affiliated researchers by providing advice and assistance with state-of-the-art statistics, epidemiology, and data management. The Core will continue to serve as a center of excellence for the planning and design of investigator-initiated observational studies and behavioral interventions to reduce the risk of HIV infection on the individual, couple, group, and community levels. It will identify previously unrecognized statistical needs and study design improvements at the earliest planning stages in order to generate innovative solutions. The SED Core will meet the biostatistical, epidemiologic, and data management needs of Center-affiliated studies in a centralized and unified manner, consistent with modern principles of conduct of randomized controlled trials for behavioral intervention studies and observational methods for comparative or descriptive, nonexperimental studies. With its tripartite structure, the Core provides an interrelated network of talented specialists who are interdisciplinary and collaborate on all aspects of marshaling evidence: study design and instrumentation, anticipation and avoidance of bias, data management, statistical analysis and weighing of evidence, and interrelation with other disciplines to evaluate evidence and make causal inferences. The Statistics Component increases the likelihood that the randomized trials and observational studies will achieve their scientific goals through the application of good statistical principles and practices that minimize threats to validity. The biostatistical faculty and staff in the Core are highly experienced in collaborating with investigators in keeping studies on target and are pro-active in identifying and seeking resolutions to new statistical problems. The Epidemiology Component sits at the interface of the behavioral and biomedical sciences and thus is uniquely positioned to contribute to the articulation and refinement of research questions, to the selection of appropriate study designs, to the resolution of issues that arise in the field, and to the interpretation of the resulting data. The Data Management Component provides state-of-the-art management of research information, including forms production, relational database management and web-based research products. The integration of these skills and resources into one Core has led to a synergistic interaction of disciplines to identify and develop specific technical methods and products that will enhance the research productivity of the Center and support new and innovative research. The SED Core also organizes preparation for Performance, Safety & Monitoring Board meetings and coordinates responses to PSMB queries and recommendations.

统计，流行病学和数据管理核心（SED）将提高HIV研究并改善 艾滋病毒中心附属研究人员提交的提案质量，通过提供建议和 协助最先进的统计数据，流行病学和数据管理。核心将继续 作为研究人员发起的观察的卓越中心 研究和行为干预措施，以减少对个人，夫妇，组， 和社区层面。它将确定以前未认可的统计需求和研究设计 在最早的计划阶段进行改进，以生成创新的解决方案。 SED核心 将满足中心相关研究的生物统计学，流行病学和数据管理需求 集中式和统一的方式，与现代的随机控制行为原则一致 进行行为干预研究和比较或描述性的观察方法的试验 研究。核心提供了三方结构，提供了一个相互关联的才华横溢的网络 跨学科的专家，并在整理证据的各个方面进行合作：研究设计 以及仪器，预期和避免偏见，数据管理，统计分析以及 权衡证据，并与其他学科的相互关系以评估证据并使因果关系 推论。统计成分增加了随机试验和 观察研究将通过应用良好的统计原则实现其科学目标 以及最大程度地减少对有效性威胁的实践。核心的生物统计学教师和核心工作人员很高 与调查人员合作的经验，可以保持对目标的研究，并积极主动 确定并寻求解决新统计问题的决议。流行病学组成部分位于 行为和生物医学科学的界面，因此具有独特的位置，以促进 研究和完善研究问题，选择适当的研究设计，向 解决现场出现的问题以及对结果数据的解释。数据 管理组件提供研究信息的最新管理，包括表格 生产，关系数据库管理和基于Web的研究产品。这些的整合 技能和资源成为一个核心，导致了学科的协同互动，以识别和发展 具体的技术方法和产品将提高中心的研究生产率和 支持新的创新研究。 SED核心还为绩效，安全组织组织准备 和监视委员会会议，并协调对PSMB查询和建议的响应。