Neurocognitive Effects of Stress

压力对神经认知的影响

• 批准号: 8197074
• 负责人: Jeansok John Kim
• 金额: $ 30.52万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197074
• 关键词: Amygdaloid structure; Animal Experimentation; Anxiety; Attenuated; Behavior; Behavioral; Binding; Brain; Cells; Chemicals; Code; Cognitive; Corticosterone; Data; Decision Making; Disease; Drug usage; Elements; Endocrine; Episodic memory; Glucocorticoids; Goals; Grant; Health; Hippocampus (Brain); Human; Impairment; Information Storage; Learning; Lesion; Life; Long-Term Potentiation; Mediating; Memory; Mental Depression; Modeling; Nature; Neurobiology; Neurocognition; Neurocognitive; Neurons; Pattern; Performance; Play; Prefrontal Cortex; Process; Psychopathology; Rattus; Relapse; Research; Research Project Grants; Rodent; Role; Schizophrenia; Short-Term Memory; Societies; Stress; Structure; Synaptic plasticity; System; Techniques; Testing; Time; Update; Work; awake; base; cognitive function; density; insight; relating to nervous system; stress related disorder

Stress contributes to myriad psychopathologies, including anxiety, depression, schizophrenia, and drug use relapse. A common thread binding these disorders appears to be the stress-associated alteration in cognitive processes, namely learning and memory. Considerable human and animal research has shown that the hippocampus, a brain structure necessary for the formation of stable declarative (or explicit) memory, is highly susceptible to stress. Rodent studies further indicate that stress impairs long-term potentiation (LTP), a leading candidate cellular mechanism of information storage, in the hippocampus. We have recently discovered that the amygdala plays a necessary, time-dependent role in the emergence of stress effects on hippocampal LTP and memory. Accordingly, we hypothesize that the amygdala is an important component of the central stress mechanism that regulates neurocognitive functioning. The long-term goal of this research is to construct a general experimental and theoretical basis for understanding how stress influences the hippocampus¿from synaptic plasticity to neural activity to behavior¿and incorporate this in a systems-level model that can organize existing data, predict new results, and generalize to other cognitive processes impacted by stress. There are four specific aims of the project: (1) an IN VITRO ANALYSIS will investigate the central stress mechanism altering hippocampal LTP; (2) a BEHAVIORAL ANALYSIS will determine the nature of central stress mechanism influencing hippocampal memory; (3) a SINGLE UNIT ANALYSIS will relate stress effects on specific behaviors with the activity of hippocampal neurons; and (4) GENERALIZATION OF THE MODEL will test whether the central stress mechanism identified in the first three aims is applicable to other types of learning and memory. Information generated from this project would be of significance (1) from a basic scientific perspective, providing valuable insights into the neuronal substrates underlying stress effects on neurocognition; and (2) from an applied perspective, providing testable hypotheses for explaining neurobiological changes that occur during stressful situations, thereby allowing insights into and treatment of various stress-related disorders that severely limit the quality of human life in today¿s increasingly hectic and long-living society.

压力会导致无数的心理病理学，包括焦虑，抑郁，精神分裂症和药物 使用继电器。结合这些疾病的共同线程似乎是应力相关的改变 认知过程，即学习和记忆。大量的人类和动物研究表明 海马是形成稳定声明（或显式）记忆所必需的大脑结构，是 高度容易受到压力。啮齿动物的研究进一步表明，压力会损害长期潜力（LTP），A 海马中的领先候选细胞机制。我们最近有 发现杏仁核在压力影响的出现中起着必要的时间依赖性作用 海马LTP和内存。彼此之间，我们假设杏仁核是重要组成部分 调节神经认知功能的中央应力机制。这项研究的长期目标是 构建一个一般的实验和理论基础，以理解压力如何影响 海马从合成可塑性到神经活动再到行为，并将其纳入系统级别 可以组织现有数据，预测新结果并推广到其他认知过程的模型 受压力的影响。 该项目有四个特定的目的：（1）体外分析将研究中心应力 改变海马LTP的机制； （2）行为分析将确定中央的性质 压力机制影响海马记忆； （3）单位分析将与压力效应相关 关于海马神经元活性的特定行为； （4）模型的概括 将测试前三个目标中确定的中央应力机制是否适用于其他类型 学习和记忆。 从该项目产生的信息将具有重要意义（1）从基本的科学角度来看， 提供对压力对神经认知影响的神经元底物的宝贵见解； （2） 从应用的角度来看，提供了可检验的假设来解释发生的神经生物学变化 在压力大的情况下，从而允许对各种压力相关的疾病的见解和治疗 严重限制了当今人类生活的质量。越来越忙碌而悠久的社会。

项目成果

Prefrontal cortex and hippocampus subserve different components of working memory in rats.

前额叶皮层和海马体促进大鼠工作记忆的不同组成部分。

• DOI: 10.1101/lm.850808
• 发表时间: 2008
• 期刊: Learning & memory (Cold Spring Harbor, N.Y.)
• 作者: Yoon,Taejib;Okada,Jeffrey;Jung,MinW;Kim,JeansokJ
• 通讯作者: Kim,JeansokJ

Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice.

慢性压力改变行为小鼠的空间表征和位置细胞的爆发模式。

• DOI: 10.1038/srep16235
• 发表时间: 2015
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Park,Mijeong;Kim,Chong-Hyun;Jo,Seonmi;Kim,EunJoo;Rhim,Hyewhon;Lee,CJustin;Kim,JeansokJ;Cho,Jeiwon
• 通讯作者: Cho,Jeiwon

Early life manipulations alter learning and memory in rats.

• DOI: 10.1016/j.neubiorev.2012.07.003
• 发表时间: 2012-10
• 期刊: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
• 影响因子: 8.2
• 作者: Kosten, Therese A.;Kim, Jeansok J.;Lee, Hongjoo J.
• 通讯作者: Lee, Hongjoo J.

Hippocampal lesion effects on occasion setting by contextual and discrete stimuli.

海马损伤对情境和离散刺激的场合设置的影响。

• DOI: 10.1016/j.nlm.2010.07.001
• 发表时间: 2011
• 期刊: Neurobiology of learning and memory
• 影响因子: 2.7
• 作者: Yoon,Taejib;Graham,LaurenK;Kim,JeansokJ
• 通讯作者: Kim,JeansokJ

Social transmission of fear in rats: the role of 22-kHz ultrasonic distress vocalization.

• DOI: 10.1371/journal.pone.0015077
• 发表时间: 2010-12-01
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kim EJ;Kim ES;Covey E;Kim JJ
• 通讯作者: Kim JJ