Brain and behavior correlates of prenatal cannabis exposure

产前大麻暴露的大脑和行为相关性

基本信息

批准号：
10734717
负责人：
STEPHEN R DAGER
金额：
$ 69.61万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734717
关键词：
ATOD Affect Age Age Months Alcohols Amygdaloid structure Animal Experimentation Animals Antiemetics Anxiety Attention Behavior Behavioral Binding Biological Assay Birth Birth Weight Brain Brain imaging Brain region COVID-19 pandemic Cannabidiol Cannabinoids Cannabis Cell Adhesion Molecules Cerebellum Complementary and alternative medicine Conceptions Conscious Consumption Data Development Diffusion Magnetic Resonance Imaging Disease Dopamine D2 Receptor Dose Early Diagnosis Educational Status Endocannabinoids Enrollment Evaluation Exclusion Criteria Exhibits Female First Pregnancy Trimester Frequencies Functional Magnetic Resonance Imaging Goals Growth Head circumference Health Health Benefit Human Illicit Drugs Infant Influentials Label Legal Legal Status Length Magnetic Resonance Imaging Measures Medicine Memory Modernization Monitor Mothers Multimodal Imaging Nausea and Vomiting Neonatal Neurodevelopmental Disorder Neuropsychology Newborn Infant Odors Outcome Outcomes Research Pacific Northwest Participant Pathway interactions Patient Self-Report Perception Persons Pharmacologic Substance Placenta Population Pregnancy Pregnant Women Product Labeling Property Prospective Studies Protocols documentation Psychotropic Drugs Recreation Regulation Reporting Research Risk Second Pregnancy Trimester Sex Differences Signal Transduction Sleep Stimulus Structure System Testing Tetrahydrocannabinol Third Pregnancy Trimester Time Tobacco Update Urine Visit Washington Woman Work adverse outcome autism spectrum disorder behavior measurement behavioral outcome brain dysfunction cannabinoid receptor density design drug of abuse experience fetal marijuana exposure follow up assessment frontal lobe imaging study in utero indexing infancy infant outcome innovation male marijuana legalization marijuana use marijuana use in pregnancy marijuana user maternal marijuana use motor behavior myelination neural neurobehavior neurobehavioral neurodevelopment pain reduction polysubstance use pregnant prenatal prenatal exposure programs prospective receptor density recruit response reward processing symptom management white matter

项目摘要

Cannabis use during pregnancy has increased substantially, in conjunction with widespread decriminalization/legalization, changing public perceptions about harm, and evidence of cannabis's antiemetic properties. Prior outcomes research on prenatal cannabis exposure is narrow in scope, as these older studies included research participants with polysubstance use (e.g., tobacco, alcohol, illicit drugs). In addition, prior research also likely underestimated potential risks specific to cannabis use during pregnancy because modern strains are 10x more potent than they were 40 years ago. We propose to study neurodevelopment in infants exposed in utero to cannabis using state-of-the-art MRI and behavioral measures. Maternal cannabis use will be measured prospectively using weekly reports validated with labels and urine-based assays. By focusing on infancy, we aim to characterize cannabis-induced brain changes at a time when environmental effects are minimized and are less influential than at older. In addition, we will test the hypothesis that prenatal cannabis exposure is more detrimental to male than females. To test our hypotheses, we will recruit 200 pregnant people (where the mother uses cannabis, but not other drugs, tobacco, or alcohol) and 170 pregnant control participants matched on education level. Infants will receive a neonatal neurobehavioral exam and multi-modal imaging (functional magnetic resonance imaging, diffusion tensor imaging, and structural MRI) under natural sleep at 2-4 weeks-of-age and extensive neuropsychological follow-up assessments at 6 and 18 months. This program of research aims to clarify potential health risks, enabling pregnant people to make better-informed choices surrounding cannabis use during pregnancy.

怀孕期间的大麻使用大大增加了，并普遍存在非刑事化/合法化，改变公众对损害的看法以及大麻抗气的证据特性。这些较旧的研究，有关产前大麻暴露的先前结果研究范围很狭窄包括使用多物质使用的研究参与者（例如烟，酒精，非法药物）。另外，先验研究还可能低估了怀孕期间大麻使用的潜在风险菌株比40年前的功率高10倍。我们建议研究婴儿的神经发育使用最先进的MRI和行为指标，在子宫内暴露于大麻中。孕产妇大麻使用可以使用标签和基于尿液的测定验证的每周报告对前瞻性测量。通过关注婴儿期，我们旨在表征大麻引起的大脑变化，而环境影响是最小化和影响力不如较旧的影响力。此外，我们将测试产前大麻的假设与女性相比，暴露对男性更有害。为了检验我们的假设，我们将招募200个怀孕人们（母亲使用大麻，但不使用其他药物，烟草或酒精）和170个怀孕控制参与者在教育水平上匹配。婴儿将接受新生儿神经行为检查和多模式在天然下成像（功能性磁共振成像，扩散量张量成像和结构MRI）在2-4周的2-4周睡眠和6个月和18个月的广泛神经心理随访评估。这研究计划旨在澄清潜在的健康风险，使孕妇能够使知情更加信息怀孕期间大麻使用的选择。