Dietary Selenium, Selenoenzyme Genes and Adult Glioma

膳食硒、硒酶基因和成人神经胶质瘤

• 批准号: 8509399
• 负责人: Kathleen M. Egan
• 金额: $ 8.43万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509399
• 关键词: Adult; Adult Glioma; Anabolism; Antioxidants; Area; Biological Availability; Blood; Cardiovascular Diseases; Case-Control Studies; Cell physiology; Central Nervous System Neoplasms; Chemopreventive Agent; Clip; Communities; DNA; Development; Diet; Dietary Selenium; Environmental Risk Factor; Enzymes; Etiology; Evaluation; Excess Mortality; Funding; GCLM gene; Genes; Genetic Predisposition to Disease; Genetic Risk; Genetic Variation; Genotype; Glioblastoma; Glioma; Glutathione; Grant; Human; Immunity; Intake; Investigation; Link; Malignant Neoplasms; Measures; Mediating; Medical center; Nail plate; Outcome; Oxidation-Reduction; Participant; Patients; Population Study; Prevention Research; Research; Resources; Risk; Risk Factors; Role; Selenium; Single Nucleotide Polymorphism; Structure of nail of toe; Trace Elements; base; cancer prevention; cost effective; gene function; mortality; programs; public health relevance; response; selenoenzyme; selenoprotein; tumor

DESCRIPTION (provided by applicant): The proposal is submitted in response to PAR-11-079 (Cancer Prevention Research Small Grant Program). Glioma is a lethal human malignancy of unknown etiology. The aims of this project are to conduct an exploratory investigation on the relationships of selenium (Se), an essential trace mineral linked to cancer and cardiovascular disease, and genetic variation in selenoproteins which mediate the major cellular functions of Se, with risk and survival in glioma. Increased intake of Se has been suggested to have anticarcinogenic effects through cellular protective and redox antioxidant functions, though no population study has yet examined the role of Se in glioma. The project will be based on a multicenter NCI-funded (R01 CA116174) case-control study exploring genetic and environmental risk factors for adult glioma underway at medical centers in the Southeastern US. Nail clippings for assessment of trace elements and DNA for study of genetic susceptibility are available for all study participants. Specific aims of this project are to: 1) Measure toenail Se i 250 incident glioma cases and 250 matched community controls; 2) Genotype functional or tagging single nucleotide polymorphisms (SNPs) in the selenoenzymes in approximately1200 cases and 1200 controls; and 3) Evaluate associations of dietary Se and selenoenzyme genotypes for relationships with glioma risk and patient outcome. To our knowledge, this will be the first study to investigate dietary Se as a glioma risk factor. The project will also provide th first comprehensive evaluation of genetic variation in selenoenzymes in glioma. Based on a large, completed case-control study, the project offers cost-effective and timely new information on a potential dietary risk factor, mechanisms for tumor development, and promising new areas for research.

描述（由申请人提供）：该提案是针对Par-11-079（预防癌症研究小补助计划）提交的。神经胶质瘤是未知病因的致命人类恶性肿瘤。该项目的目的是对硒（SE）的关系进行探索性研究，硒（SE），与癌症和心血管疾病相关的必不可少的痕量矿物质，以及硒蛋白的遗传变异，介导SE的主要细胞功能，在SE的主要细胞功能，具有风险和存活率神经胶质瘤。尽管尚无人群研究尚未检查SE在神经胶质瘤中的作用，但已建议通过细胞保护性和氧化还原抗氧化功能的摄入量增加来具有抗癌作用。该项目将基于由NCI资助的（R01 CA116174）的病例对照研究，探讨美国东南部医疗中心成人神经胶质瘤的遗传和环境危险因素。用于评估痕量元素和DNA的指甲剪辑可用于所有研究参与者。该项目的具体目的是：1）测量Toenail SE I 250事件胶质瘤病例和250个匹配的社区控制； 2）在大约1200例和1200个对照中，基因型功能或标记单核苷酸多态性（SNP）； 3）评估饮食中的SE和硒酶基因型与神经胶质瘤风险和患者结局的关系。据我们所知，这将是首次研究作为神经胶质瘤危险因素的饮食中SE的研究。该项目还将对神经胶质瘤中硒酶的遗传变异进行首次全面评估。基于一项大型，完整的病例对照研究，该项目提供了有关潜在的饮食危险因素，肿瘤发育机制以及有希望的新研究领域的成本效益和及时的新信息。