Effects of Partner Violence and Mental Health on HIV Disease Progression in Women

伴侣暴力和心理健康对女性艾滋病毒疾病进展的影响

基本信息

批准号：
8541098
负责人：
Jocelyn Christine Anderson
金额：
$ 4.22万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8541098
关键词：
Address Adherence Adult Affect African American Alcohol consumption Battered Women Behavior Biological Markers CD4 Lymphocyte Count Caring Characteristics Chronic stress Clinic Clinic Visits Coercion Complex Data Diagnosis Disease Disease Progression Drug usage Epidemic Female Goals HIV HIV-1 Health Hospitalization Immune response Individual Intervention Interview Life Link Literature Low income Mediating Medical Records Mental Depression Mental Health Mental disorders Methods Opportunistic Infections Outcome Participant Pathway interactions Perception Phase Population Post-Traumatic Stress Disorders Predisposition Pregnancy Pregnancy Outcome Prevalence Recording of previous events Recruitment Activity Reporting Research Risk Risk Factors Role Sexually Transmitted Diseases Substance abuse problem Surveys Survivors Symptoms Time Treatment outcome Violence Viral Load result Virus Diseases Woman acute stress biological adaptation to stress birth control career condoms depressive symptoms emotional abuse experience health disparity high risk high risk sexual behavior improved intimate partner violence knowledge base male medication compliance mortality partner violence phase 1 study physical abuse pressure public health relevance reproductive sex sex risk treatment adherence unintended pregnancy violence against women

项目摘要

DESCRIPTION (provided by applicant): The proposed mixed-methods study aims to examine the complex relationship between intimate partner violence (IPV) and reproductive coercion, mental health and HIV treatment adherence and disease progression. Pathways including substance abuse, depression and post-traumatic stress disorder will be examined. Women will be recruited from an urban HIV clinic that serves a primarily low income, African American population. African American women are disproportionally affected by the intertwined epidemics of HIV, violence and substance abuse. Phase 1 of the study will include quantitative data regarding past year, IPV, reproductive coercion, PTSD symptoms, depressive symptoms, substance abuse, and HIV medication adherence collected from eligible women. Participant's medical records will be reviewed to obtain biologic markers of disease progression and medication adherence (CD4 count and viral load) as well as covariates related to HIV disease progression (hospitalizations, opportunistic infections) and verification of mental health related diagnoses (PTSD, depression, substance abuse). Prevalence of IPV and reproductive coercion will be estimated, prior to examining the direct and mediated effects of IPV and reproductive coercion on HIV disease progression and treatment adherence (CD4 counts, viral load and missed clinic visits). Following analysis of Phase 1 data, a subsample of women will be purposefully selected for Phase 2 qualitative interviews. The aim of these qualitative interviews is to explore women's perceptions on IPV and reproductive coercion and the role in adherence and disease progression. The findings from the proposed study will be used to inform culturally competent interventions to reduce health disparities among urban, HIV positive women.

描述（由申请人提供）：拟议的混合方法研究旨在研究亲密伴侣暴力（IPV）与生殖胁迫，心理健康和HIV治疗遵守和疾病进展之间的复杂关系。将检查包括药物滥用，抑郁症和创伤后应激障碍的途径。妇女将从一个城市艾滋病毒诊所招募，该诊所主要是低收入的非裔美国人人口。非洲裔美国妇女受到艾滋病毒，暴力和滥用毒品的交织流行的影响不成比例。该研究的第1阶段将包括有关过去一年，IPV，生殖胁迫，PTSD症状，抑郁症状，药物滥用和HIV药物依从性的定量数据。将审查参与者的病历，以获取疾病进展和药物依从性（CD4计数和病毒负荷）的生物学标志物以及与HIV疾病进展（住院，机会性感染）和心理健康相关诊断（PTSD，PTSD，PTSD，抑郁症，药物滥用）的协变量。在检查IPV和生殖胁迫对HIV疾病进展和治疗依从性的直接和介导作用之前，将估算IPV和生殖胁迫的患病率（CD4计数，病毒载量和错过的诊所就诊）。在对第1阶段数据的分析后，将有目的地选择女性的子样本进行第二阶段定性访谈。这些定性访谈的目的是探索妇女对IPV和生殖胁迫的看法，以及在依从性和疾病进展中的作用。拟议的研究的发现将用于为具有文化胜任的干预措施提供信息，以减少城市艾滋病毒阳性妇女的健康差异。