BMI-based Prenatal Vitamins to Ameliorate Oxidative Stress in Obese Pregnancy

基于 BMI 的产前维生素可改善肥胖妊娠期的氧化应激

基本信息

批准号：
8581677
负责人：
Sarbattama Sen
金额：
$ 13.35万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-15 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8581677
关键词：
8-hydroxy-2&apos -deoxyguanosine Admission activity Adverse effects Affect Animal Model Antioxidants Ascorbic Acid Award Biochemical Biological Markers Body mass index Breast Feeding C-reactive protein Cells Child Clinical Clinical Research Clinical Trials Design Collaborations Commit Conduct Clinical Trials Congenital Abnormality Core Facility Data Diet Dose Environment Epidemic Equilibrium Erythrocytes Faculty Folate Foundations Future Future Generations Generations Glutathione Disulfide Growth Health Health Care Costs Immunology Infant Inflammation Intervention Intervention Studies Life Link Lipid Peroxidation Long-Term Effects Master&apos s Degree Maternal Health Measures Medical center Medicine Mentors Metabolic Metabolism Micronutrients Morbidity - disease rate Mothers Neonatal Obesity Outcome Oxidants Oxidative Stress Pathway interactions Pediatric Hospitals Perinatal Play Population Predisposition Pregnancy Pregnant Women Principal Investigator Program Development Prostaglandins Public Health Randomized Randomized Controlled Trials Recruitment Activity Regimen Research Research Personnel Research Project Grants Resources Rodent Model Role Sampling Serum Supplementation Testing Time Tissues Training Training Programs Translational Research Umbilical Cord Blood United States Universities Vitamins Weight Gain Woman Work base career combat cost effective experience improved infant outcome inflammatory marker innovation intergenerational mortality neonate next generation novel nutrition offspring oxidation oxidative DNA damage pediatric department premature prenatal professor public health relevance reproductive health intervention therapy design urinary

项目摘要

DESCRIPTION (provided by applicant): This K23 application summarizes a five-year training program for the development of the academic career of Dr. Sarbattama Sen in Neonatal-Perinatal Medicine. Dr. Sen has already shown that she is committed to becoming a leader in the field of maternal obesity research. This career training award would allow her to pursue formal training through a Master's degree in Clinical and Translational Research, with a focus on designing interventions and conducting clinical trials to improve maternal and neonatal outcomes in obese pregnancy. She will benefit from the experience of an expert mentoring team. Her primary mentor will be Dr. Simin Meydani, Professor of Nutrition and Immunology at Tufts University and a renowned expert in micronutrient intervention studies. Her co-mentors will be Dr. Marlene Goldman, an expert in antioxidant interventions and reproductive health, Dr. David Greenblatt, an expert in pharmacologic interventions and obesity and Dr. Norma Terrin, an expert in clinical trial design. Dr. Diana Bianchi and Dr. Jonathan Davis will serve as career mentors. The academic environment at Tufts University and The Department of Pediatrics at Tufts Medical Center/Floating Hospital for Children is an ideal training environment, with an established track record of successfully transitioning junior faculty to independent researchers. In addition, Tufts University and the Jean Mayer USDA HNRCA provide an unparalleled combination of resources, core facilities, intellectual expertise and potential collaborations in nutrition and obesity research. The proposed research project, "BMI-based prenatal vitamins to ameliorate oxidative stress in obese pregnancy," is a novel intervention aimed at decreasing oxidative stress and inflammation, key abnormalities in the intrauterine milieu of obese pregnancy. Dr. Sen previously identified the importance of oxidative stress in the causative pathway of intergenerational obesity in an animal model, and her pilot data shows that oxidative stress is markedly increased, and antioxidant defenses markedly depleted, in obese pregnant women. This trial is a logical extension of this previous work. Her central hypothesis is that obese pregnancy is characterized by an oxidant/antioxidant imbalance, which increases inflammation and adversely impacts maternal health and neonatal outcome. Restoring oxidant/antioxidant balance with a body mass index-based prenatal micronutrient supplement will decrease oxidative stress and inflammation and improve both maternal and neonatal outcomes in obese pregnancy. This hypothesis will be tested in a randomized controlled trial in obese pregnant women. Given its overwhelming current and future impact, innovative approaches to diminish the effect of maternal obesity on future generations are of paramount public health importance.

描述（由申请人提供）：这份 K23 申请总结了 Sarbattama Sen 博士在新生儿围产期医学学术生涯发展的五年培训计划。森博士已经表明她致力于成为孕产妇肥胖研究领域的领导者。该职业培训奖将使她能够通过临床和转化研究硕士学位进行正式培训，重点是设计干预措施和进行临床试验，以改善肥胖妊娠的孕产妇和新生儿结局。她将受益于专家指导团队的经验。她的主要导师是塔夫茨大学营养与免疫学教授、微量营养素干预研究领域的著名专家 Simin Meydani 博士。她的共同导师包括抗氧化干预和生殖健康专家 Marlene Goldman 博士、药理干预和肥胖专家 David Greenblatt 博士以及临床试验设计专家 Norma Terrin 博士。戴安娜·比安奇博士和乔纳森·戴维斯博士将担任职业导师。塔夫茨大学和塔夫茨医疗中心/浮动儿童医院儿科的学术环境是理想的培训环境，拥有成功将初级教师转变为独立研究人员的良好记录。此外，塔夫茨大学和 Jean Mayer USDA HNRCA 在营养和肥胖研究方面提供无与伦比的资源、核心设施、知识专长和潜在合作组合。拟议的研究项目“基于体重指数的产前维生素改善肥胖妊娠的氧化应激”是一项新颖的干预措施，旨在减少氧化应激和炎症，这是肥胖妊娠子宫内环境的关键异常。森博士之前在动物模型中确定了氧化应激在代际肥胖致病途径中的重要性，她的试验数据显示，肥胖孕妇的氧化应激显着增加，抗氧化防御显着降低。这项试验是先前工作的逻辑延伸。她的中心假设是，肥胖妊娠的特点是氧化剂/抗氧化剂失衡，这会增加炎症并对孕产妇健康和新生儿结局产生不利影响。通过基于体重指数的产前微量营养素补充剂恢复氧化剂/抗氧化剂平衡将减少氧化应激和炎症，并改善肥胖妊娠的孕产妇和新生儿结局。这一假设将在肥胖孕妇的随机对照试验中得到检验。鉴于其对当前和未来的巨大影响，减少孕产妇肥胖对子孙后代影响的创新方法对于公共卫生至关重要。