A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy

怀孕期间阴道微生物组的多组学分析

基本信息

批准号：
8617339
负责人：
Gregory Allen Buck
金额：
$ 250万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-06 至 2016-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the U.S., the annual cost of health care for newborns with complications approaches $26 billion, and worldwide, preterm birth is the leading cause of morbidity and mortality among neonates. Despite improved survival rates, the past few decades have seen no significant decrease in preterm births. It is becoming more clear that the billions of bacteria that colonize the human body play important roles in the health of the individual. However, the role of the millions of bacteria and other microbes that colonize the human female urogenital tract in prenatal health and birth of a healthy baby remains obscure. Previous to the recent development of 'omics' technologies; i.e., genomics, transcriptomics, proteomics, metabolomics, interactomics, etc., it was not possible to study these microbial populations in any in depth or highly efficient way. Many of these organisms have never been characterized and a fairly large fraction have not been successfully cultured. Herein, we propose to use these 'omic' technologies to dissect the bacterial populations that inhabit and colonize the female urogenital tract of pregnant women to assess the role(s) of these organisms in maintenance of health or in the cause of disease in these women and their babies. An understanding of the roles these organisms play in the health of the female urogenital tract will lead to better, more efficient prenatal and postnatal care, likely leading to diminished levels of preterm birth and infant morbidity and mortality.

描述（由申请人提供）：在美国，患有并发症的新生儿每年的医疗费用接近 260 亿美元，而在世界范围内，早产是新生儿发病和死亡的主要原因。尽管存活率有所提高，但过去几十年来早产率并没有显着下降。人们越来越清楚地认识到，寄居在人体中的数十亿细菌对个人健康发挥着重要作用。然而，人类女性泌尿生殖道中数以百万计的细菌和其他微生物在产前健康和健康婴儿出生中的作用仍然不清楚。早于“组学”技术的最新发展；即基因组学、转录组学、蛋白质组学、代谢组学、相互作用组学等，不可能以任何深入或高效的方式研究这些微生物种群。其中许多生物体从未被表征过，并且相当大一部分尚未成功培养。在此，我们建议使用这些“组学”技术来剖析居住和定殖于孕妇女性泌尿生殖道的细菌种群，以评估这些生物体在维持这些妇女的健康或导致疾病方面的作用和他们的孩子。了解这些微生物在女性泌尿生殖道健康中发挥的作用将带来更好、更有效的产前和产后护理，可能导致早产和婴儿发病率和死亡率的降低。