A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy

怀孕期间阴道微生物组的多组学分析

基本信息

批准号：
8731192
负责人：
Gregory Allen Buck
金额：
$ 250万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-06 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8731192
关键词：
Abdominal colic Accounting Address Bacteria Bacterial Genome Birth Cells Clinic Controlled Environment Data Databases Developed Countries Development Disease Enrollment Environment Female Fetus Funding Generations Genes Genitourinary system Genomics Gestational Diabetes Health Health Care Costs Human Microbiome Human body Immune Immune response Incidence Individual Infant Infection Inflammation Lead Life Low Birth Weight Infant Maintenance Maps Measures Mediating Metabolic Metagenomics Microbe Morbidity - disease rate Necrotizing Enterocolitis Neonatal Newborn Infant Organism Outcome Participant Pathway interactions Play Population Population Study Postnatal Care Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Premature Infant Premature Labor Premature Rupture Fetal Membranes Prenatal care Proteomics Recombinant DNA Regulatory Pathway Research Personnel Risk Role Sampling Shotgun Sequencing Signal Pathway Survival Rate System Taxonomy Technology Testing Uterine cavity Vagina Woman Women&apos s Health cohort cytokine fetal genome sequencing human female improved infant morbidity/mortality insight interest metabolomics microbial microbiome microorganism mortality neonatal morbidity neonate perinatal health premature prenatal health prevent protein protein interaction rRNA Genes stillbirth transcriptomics

项目摘要

In the U.S., the annual cost of health care for newborns with complications approaches $26 billion, and worldwide, preterm birth is the leading cause of morbidity and mortality among neonates. Despite improved survival rates, the past few decades have seen no significant decrease in preterm births. It is becoming more clear that the billions of bacteria that colonize the human body play important roles in the health of the individual. However, the role of the millions of bacteria and other microbes that colonize the human female urogenital tract in prenatal health and birth of a healthy baby remains obscure. Previous to the recent development of 'omics' technologies; i.e., genomics, transcriptomics, proteomics, metabolomics, interactomics, etc., it was not possible to study these microbial populations in any in depth or highly efficient way. Many of these organisms have never been characterized and a fairly large fraction have not been successfully cultured. Herein, we propose to use these 'omic' technologies to dissect the bacterial populations that inhabit and colonize the female urogenital tract of pregnant women to assess the role(s) of these organisms in maintenance of health or in the cause of disease in these women and their babies. An understanding of the roles these organisms play in the health of the female urogenital tract will lead to better, more efficient prenatal and postnatal care, likely leading to diminished levels of preterm birth and infant morbidity and mortality.

在美国，患有并发症的新生儿每年的医疗费用接近 260 亿美元，在世界范围内，早产是新生儿发病和死亡的主要原因。尽管有所改善存活率方面，过去几十年来早产率没有显着下降。它正在成为更清楚的是，寄居在人体中的数十亿细菌对人体健康发挥着重要作用。个人。然而，寄居在人类女性体内的数以百万计的细菌和其他微生物的作用泌尿生殖道在产前健康和健康婴儿出生方面的影响仍然不清楚。之前到最近 “组学”技术的开发；即基因组学、转录组学、蛋白质组学、代谢组学、相互作用组学等，不可能深入或高效地研究这些微生物种群方式。其中许多生物体从未被表征过，并且相当大一部分还没有被表征过。培养成功。在这里，我们建议使用这些“组学”技术来剖析细菌居住在孕妇女性泌尿生殖道的人群，以评估其作用这些生物体维持这些妇女及其婴儿的健康或导致疾病。一个了解这些生物体在女性泌尿生殖道健康中所发挥的作用将导致更好、更有效的产前和产后护理，可能会导致早产和产后水平下降婴儿发病率和死亡率。