Medical University of South Carolina - Cancer Center Support Grant

南卡罗来纳医科大学 - 癌症中心支持补助金

• 批准号: 8138939
• 负责人: Andrew S Kraft
• 金额: $ 8.47万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8138939
• 关键词: Medical; University; South; Carolina; Cancer

DESCRIPTION (provided by applicant): The Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC) seeks National Cancer Institute (NCI) designation via the P30 Cancer Center Support Grant mechanism to support its mission to reduce the cancer burden in South Carolina and beyond. As South Carolina's leading academic medical center, MUSC has been charged and supported over the past decade to build clinical, basic, translational and population-based research programs that address the state's significant cancer morbidity and mortality. Through the support of an NCI P20 Planning Grant (2001-2007), the HCC has recruited and organized 97 cancer scientists, representing six MUSC Colleges - Medicine, Pharmacy, Dental Medicine, Nursing, Health Professions and Graduate Studies - into productive and collaborative cancer research programs. These programs are: Lipid Signaling in Cancer, Cancer Genes & Molecular Regulation, Developmental Cancer Therapeutics and Cancer Immunology. A Cancer Prevention & Control program is in development. The HCC has expanded and continues to expand its research facilities and resources to enhance further growth. In 2006, the HCC completed a seven story tower adjacent to its original 85,761 ft[2] building adding more than 116,000 ft2 in research, clinical and administrative space, and MUSC has committed an additional 62,000 ft2 of research space to the HCC in two new buildings starting construction in summer 2008. As part of this P30 application, five shared research resources will be presented: Lipidomics, Flow Cytometry & Cell Sorting, Cell & Molecular Imaging, Biostatistics and Clinical Trials. The HCC has invested $1.6 million since 2004 into enhancing these five essential and critical resources. Given the rapid and ongoing development of research in the programs, the HCC has also invested another $6 million in initiating the development and optimizing the function of seven other shared resources that will greatly impact on HCC's current and future programmatic-based research initiatives. These investments have resulted in a doubling of the HCC's extramural research funding base since 2003, currently $31.2 million with NCI funding representing $12.1million. Accrual to therapeutic clinical trials has quadrupled in the same time period. This application demonstrates that HCC scientists have made significant contributions to the understanding of cancer biology and the development of novel approaches to prevent, diagnose and treat cancer.

描述（由申请人提供）：南卡罗来纳医科大学 (MUSC) 的霍林斯癌症中心 (HCC) 通过 P30 癌症中心支持拨款机制寻求国家癌症研究所 (NCI) 指定，以支持其减轻癌症负担的使命南卡罗来纳州及其他地区。作为南卡罗来纳州领先的学术医疗中心，MUSC 在过去十年中一直负责和支持建立临床、基础、转化和基于人群的研究项目，以解决该州显着的癌症发病率和死亡率。通过 NCI P20 规划拨款（2001-2007 年）的支持，HCC 招募并组织了 97 名癌症科学家，代表 MUSC 六所学院（医学、药学、牙科、护理、卫生专业和研究生院），致力于富有成效和协作的癌症研究研究计划。这些项目包括：癌症中的脂质信号传导、癌症基因和分子调控、发育性癌症治疗和癌症免疫学。癌症预防和控制计划正在制定中。 HCC 已经并将继续扩大其研究设施和资源，以促进进一步发展。 2006 年，HCC 在其原来的 85,761 英尺[2] 大楼附近建成了一座七层塔楼，增加了超过 116,000 平方英尺的研究、临床和行政空间，MUSC 已在两个新的项目中为 HCC 额外提供了 62,000 平方英尺的研究空间。建筑物于 2008 年夏季开始施工。作为 P30 应用程序的一部分，将提供五个共享研究资源：脂质组学、流量细胞计数和细胞分选、细胞和分子成像、生物统计学和临床​​试验。自 2004 年以来，HCC 已投资 160 万美元来增强这五项重要且关键的资源。鉴于这些项目研究的快速和持续发展，HCC 还投资了另外 600 万美元，用于启动其他七个共享资源的开发和功能优化，这将对 HCC 当前和未来基于项目的研究计划产生重大影响。这些投资使 HCC 的外部研究经费基础自 2003 年以来翻了一番，目前为 3,120 万美元，其中 NCI 资助为 1,210 万美元。同期治疗性临床试验的数量增加了四倍。该应用表明，肝癌科学家为理解癌症生物学以及开发预防、诊断和治疗癌症的新方法做出了重大贡献。