BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

BioSystems 网络和转化研究 - 炎症洞察 (BioSNTR-II)

• 批准号: 10593066
• 负责人: Adam David Hoppe
• 金额: $ 218.46万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593066
• 关键词: Acceleration; Animals; Area; Bioinformatics; Biological Sciences; Biomedical Research; Biotechnology; CRISPR imaging; Cell Communication; Cell Death; Cell physiology; Cells; Center for Translational Science Activities; Centers of Research Excellence; Cilia; Clinic; Clustered Regularly Interspaced Short Palindromic Repeats; Communication; Cytokine Signaling; Development; Disease; Education; Environment; Evaluation; Event; Faculty; Fostering; Funding; Genes; Genetic Transcription; Genomics; Goals; Grant; Growth; Health; Human; Inflammation; Inflammatory; Inflammatory Response; Investments; Knowledge; Labor Forces; Lymphangiogenesis; Lymphatic; Macrophage; Macrophage Cell Biology; Mentors; Microscopy; Mission; Molecular; Optics; Pathway Analysis; Pathway interactions; Performance; Personnel Management; Pilot Projects; Plants; Private Sector; Process; Program Research Project Grants; Proteins; Proteomics; Public Health; Records; Regulation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Senior Scientist; Signal Transduction; South Dakota; TNF gene; Technology; Technology Transfer; Tissues; Training Support; Translational Research; Translations; Ubiquitin; United States National Institutes of Health; Universities; University adminstration; Work; career; cohort; experience; formative assessment; immune cell infiltrate; improved; innovation; insight; instrumentation; interdisciplinary approach; medical schools; model development; next generation sequencing; programs; research and development; senior faculty; success; synergism; tenure track; transcriptome; transcriptome sequencing; transcriptomics

PROJECT SUMMARY – OVERALL The goal of this proposal is a coordinated, synergized, and integrated COBRE research program, called the “BioSystems Networks and Translational Research – Insights into Inflammation (BioSNTR-II),” at South Dakota State University (SDSU), Brookings, SD. Our research objective is to improve human health by advancing the understanding of molecular, cellular and tissue-level mechanisms of inflammation research via multi-disciplinary approaches. The overarching hypothesis is that intracellular regulatory events are governed by cell-cell communication across the macrophage, stromal and lymphatic axes during the inflammatory response and its resolution. Junior research project leaders, mentored by senior faculty, define the three research projects of BioSNTR-II in the areas of: macrophage cell biology in inflammation, the role or primary cilia in regulating lymphangiogenesis in inflammation and regulation of tumor necrosis factor signaling and cell death pathways. These projects will be supported by two cutting-edge research cores in (1) transcriptome sequencing, analysis and model development (Transcriptome and Network Analyses Core) and (2) CRISPR- based gene editing and Integrated Microscopy and Gene Evaluation (CRISPR-IMAGE). In addition, an Administrative Core is proposed to support the fiscal and personnel management, implementation, oversight and evaluation of both the research projects and the cores. The synergy and integration of these components has been carefully planned to maximize impact while supporting training, professional development, and the career potential of a cadre of bright, promising basic researchers. The Center will achieve success through the following aims: (1) Develop and manage a thriving environment for inflammation research at SDSU, (2) Establish new Research Cores to expand and enhance biomedical research at SDSU, and (3) Guide center performance and sustainability with assessment and advisory board input.

项目概要——总体 该提案的目标是协调、协同和综合的 COBRE 研究计划，称为 “生物系统网络和转化研究——炎症洞察 (BioSNTR-II)”，南方 达科他州立大学 (SDSU)，布鲁金斯，南达科他州 我们的研究目标是通过以下方式改善人类健康。 促进对炎症研究的分子、细胞和组织水平机制的理解 多学科方法的总体假设是细胞内调节事件受到控制。 在炎症过程中通过巨噬细胞、基质和淋巴轴的细胞间通讯 初级研究项目负责人在高级教师的指导下定义了这三个问题。 BioSNTR-II 的研究项目涉及以下领域：巨噬细胞生物学在炎症中的作用或主要作用 纤毛调节炎症中的淋巴管生成以及肿瘤坏死因子信号传导和细胞的调节 这些项目将得到 (1) 转录组方面的两个前沿研究核心的支持。 测序、分析和模型开发（转录组和网络分析核心）和 (2) CRISPR- 基于基因编辑和集成显微镜和基因评估（CRISPR-IMAGE）。 行政核心旨在支持财务和人事管理、实施和监督 以及对研究项目和核心部分的协同和整合的评估。 经过精心规划，以最大限度地发挥影响力，同时支持培训、专业发展和 中心将通过以下方式取得成功：培养一批聪明、有前途的基础研究人员的职业潜力。 以下目标：(1) 在 SDSU 开发和管理繁荣的炎症研究环境，(2) 建立新的研究核心以扩大和加强圣地亚哥州立大学的生物医学研究，以及 (3) 指导中心 绩效和可持续性以及评估和咨询委员会的意见。