The Conte Center for Schizophrenia Research

康特精神分裂症研究中心

• 批准号: 8061041
• 负责人: DANIEL C. JAVITT
• 金额: $ 35.76万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061041
• 关键词: Conte; Center; Schizophrenia; Research

DESCRIPTION (provided by applicant): This is an application for a new Conte Center for Schizophrenia Research based at the New York University School of Medicine (NYUSoM) and the affiliated Nathan Kline Institute for Psychiatric Research (NKI). Schizophrenia (SZ) is associated with sensory processing deficits that represent a core, but understudied, connponent of the disorder. In the auditory system, patients show deficits in basic processes such as tone matching and auditory mismatch negativity (MMN) generation. In the visual system, patients show deficits in processes such as contrast gain and integration that contribute to higher order impairments in processes such as object recognition and face recognition. Sensory deficits may relate specifically to impairments in Nmethyl- D-aspartate (NMDA) receptor-mediated neurotransmission, and are especially amenable to translational investigation using human and animal models. The Center consists of 6 projects and 3 cores, which build from pre-existing collaborations among Center investigators. Projects 1, 2 and 4 are based at NKI/NYSoM and utilize human (Javitt) and primate (Schroeder) neurophysiological, and human postmortem/laser capture microscopy/gene array (Ginsberg/Smiley) approaches to the study of sensory cortical dysfunction and impaired functional connectivity in SZ. Project 3 (Hlllyard) is based at UCSD and investigates modulatory processes underlying normal visual function. Project 5 (Cornblatt) is based at Zucker Hillside Hospital and investigates sensory processing dysfunction within the SZ prodrome. Finally, Project 6 (Weiser) is based at Sheba Hospital/Tel Aviv University and evaluates effectiveness of sarcosine (N-methylglycine), a naturally occurring NMDA agonist not currently available in the US. Cores are devoted to administration (Javitt), patient recruitment/assessment (Butler) and data management/biostatistics (Robinson/Petkova). Although traditional models of SZ focus on dopamine, more recent models focus on underlying glutamatergic dysfunction, and have received support from neurogenetic, imaging, and treatment studies, as well as challenge studies with putative NMDA antagonists. The overall goal of the Center is to develop new assessment and intervention approaches for schizophrenia based upon glutamatergic models

描述（由申请人提供）：这是一份针对位于纽约大学医学院 (NYUSoM) 和附属内森·克莱恩精神病学研究所 (NKI) 的新康特精神分裂症研究中心的申请。精神分裂症 (SZ) 与感觉处理缺陷相关，这是该疾病的核心但尚未得到充分研究。在听觉系统中，患者在音调匹配和听觉失配负性（MMN）生成等基本过程中表现出缺陷。在视觉系统中，患者在对比度增益和积分等过程中表现出缺陷，从而导致物体识别和面部识别等过程中出现更高阶的损伤。感觉缺陷可能与 N 甲基- D-天冬氨酸 (NMDA) 受体介导的神经传递，特别适合 使用人类和动物模型进行转化研究。该中心由 6 个项目和 3 个核心组成，这些项目是在中心研究人员之间现有的合作基础上建立的。项目 1、2 和 4 以 NKI/NYSoM 为基础，利用人类 (Javitt) 和灵长类动物 (Schroeder) 神经生理学以及人类尸检/激光捕获显微镜/基因阵列 (Ginsberg/Smiley) 方法来研究感觉皮层功能障碍和受损深圳的功能连接。项目 3 (Hlllyard) 位于加州大学圣地亚哥分校，研究正常视觉功能的调节过程。项目 5 (Cornblatt) 位于 Zucker Hillside 医院，研究 SZ 前驱症状内的感觉处理功能障碍。最后，项目 6 (Weiser) 位于 Sheba 医院/特拉维夫大学，评估肌氨酸（N-甲基甘氨酸）的有效性，肌氨酸是一种天然存在的 NMDA 激动剂，目前在美国尚未上市。核心致力于管理（Javitt）、患者招募/评估（Butler）和数据管理/生物统计（Robinson/Petkova）。尽管传统的 SZ 模型关注多巴胺，但最近的模型关注潜在的谷氨酸能功能障碍，并得到了神经遗传学、影像学和治疗研究以及假定的 NMDA 拮抗剂的挑战研究的支持。该中心的总体目标是基于谷氨酸能模型开发新的精神分裂症评估和干预方法