Factors for enhanced neurotoxicity in methamphetamine abuse in HIV infection

HIV感染者滥用甲基苯丙胺神经毒性增强的因素

基本信息

批准号：
8417730
负责人：
LINDA CHANG
金额：
$ 41.42万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8417730
关键词：
AIDS neuropathy Abbreviations Acquired Immunodeficiency Syndrome Advisory Committees Amino Acids Animals Antidotes Antioxidants Brain Brain Diseases Brain region Carrier Proteins Cell model Cells Clinical Committee Members Complement DNA Nucleotidylexotransferase Development Dietary Selenium Dopamine Drug abuse Equilibrium Excitatory Postsynaptic Potentials Faculty Family Genetic Glucosephosphate Dehydrogenase Glutathione Guanine HIV Hawaii Hawaiian population Health Heavy Metals Human Hydrogen Peroxide Hypoxanthines Impaired cognition Infection Institution Instruction Intake Iodide Peroxidase Knock-out Knockout Mice Label Lead Learning Letters Life Long-Term Potentiation Malnutrition Memory Mentorship Methamphetamine Micronutrients Mood Disorders Movement Mus National Institute of Drug Abuse Native Hawaiian or Other Pacific Islander Needles Neuraxis Neuronal Injury Neurotoxins Nitric Oxide Organ Oxidants Oxidation-Reduction Oxidative Stress Peroxonitrite Persons Population Predisposition Property Proteins Quantitative Reverse Transcriptase PCR Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Rodent Model Role Scientist Selenium Selenocysteine Signal Transduction Students Supplementation Surveys System Toxic effect Training Transactivation Translational Research United States Universities Viral Virus Diseases aged career development developmental disease dopamine toxicity dopamine transporter dopaminergic neuron enhancing factor glutathione peroxidase graduate student health disparity high risk sexual behavior insight intraperitoneal member methamphetamine abuse methamphetamine exposure monoamine nervous system disorder neuronal survival neuroprotection neurotoxicity non-drug prevent programs public health relevance response reuptake selenium deficiency selenoenzyme selenophosphate synthetase selenoprotein small hairpin RNA thioredoxin reductase web site

项目摘要

DESCRIPTION (provided by applicant): This application is submitted in response to PAR-09-011 Diversity-promoting Institutions Drug Abuse Research Program (DIDARP) requested by the National Institute on Drug Abuse (NIDA). This proposed research program is timely since it focuses on two ofthe major health disparity issues in Hawaii, namely, methamphetamine abuse and HIV infection. Recent surveys indicate that Native Hawaiians or other Pacific islanders have the highest rate of methamphetamine use among persons aged 12 or older in the United States. Although HIV/AIDS infection rate is relatively low in Hawaii compared to other major metropolis, the rates are increasing among Hawaiians. This DIDARP will include two primary and one pilot research projects that will focus on mechanisms and factors that might enhance neurotoxicity associated with methamphetamine of HIV. We aim to enhance the capacity for drug abuse research at UH by creating this small translational research team. This group will take advantage and build on the expertise of the few but outstanding existing clinical drug abuse and HIV researchers and basic scientists. We aim to enable UH to develop a strong clinical and translational drug abuse research program. To complement these projects, we additionally propose training and career development activities that wil offer exciting opportunities for DIDARP investigators and others at UH through the Administrative and Training Core. The Faculty in the Core will provide guidance and mentorship for these junior faculty and graduate students, through infrastructure support, educational courses, seminars, and a dedicated DIDARP website, We have obtained institutional support for two additional graduate students for the program. We also have recruited 4 distinguished External Advisory Committee members with expertise related to the proposed research; each has enthusiastically agreed to provide their advice and letter of support for the development of this DIDARP at UH.

描述（由申请人提供）：该申请是针对美国国家药物滥用研究所（NIDA）要求的，响应于09-09-09-09-09-011促进多样性的药物滥用研究计划（DIDARP）。该提出的研究计划及时是及时的，因为它专注于夏威夷的两个主要健康差异问题，即甲基苯丙胺滥用和HIV感染。最近的调查表明，夏威夷原住民或其他太平洋岛民在美国12岁以上的人中使用甲基苯丙胺的使用率最高。尽管与其他主要大都市相比，夏威夷的艾滋病毒/艾滋病感染率相对较低，但夏威夷人的率正在增加。该DIDARP将包括两个主要和一个试点研究项目，这些项目将重点关注可能增强与HIV甲基苯丙胺相关的神经毒性的机制和因素。我们旨在通过建立这个小型的翻译研究团队来增强UH的药物滥用研究能力。该小组将利用并建立在少数但出色的现有临床药物滥用以及艾滋病毒研究人员和基础科学家的专业知识的基础上。我们的目标是使UH能够制定强大的临床和翻译药物滥用研究计划。为了补充这些项目，我们还提出了培训和职业发展活动，Will通过行政和培训核心为UH提供了激动人心的调查人员和其他人的激动人心的机会。核心的教师将通过基础设施支持，教育课程，研讨会和专门的DIDARP网站为这些初级教职员工和研究生提供指导和指导，我们为该计划提供了机构支持。我们还招募了4位杰出的外部咨询委员会成员，具有与拟议研究有关的专业知识；每个人都热情同意为UH的DIDARP开发提供建议和支持证。