Regulatory Circuits and Virulence in Candida albicans

白色念珠菌的调节回路和毒力

• 批准号: 8369860
• 负责人: ALEXANDER D JOHNSON
• 金额: $ 67.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-01 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8369860
• 关键词: Address; Affect; Antifungal Agents; Bar Codes; Biochemical; Biological; Candida albicans; Carbon; Carbon Dioxide; Cells; Collection; Complex; DNA; DNA Binding; DNA Binding Domain; Data; Deletion Mutation; Disease; Dissection; Ectopic Expression; Environment; Environmental Risk Factor; Fission Yeast; Functional RNA; Gastrointestinal tract structure; Gene Targeting; Genes; Genetic Transcription; Genome; Goals; Hand; Heart; Heritability; Homologous Gene; Human; Immune; In Vitro; Individual; Infection; Injection of therapeutic agent; Intercistronic Region; Intestines; Kidney; Laboratories; Leukocytes; Life; Link; Liver; Longitudinal Studies; Modeling; Molecular; Molecular Target; Monitor; Mus; Open Reading Frames; Orthologous Gene; Output; Oxygen; Partner in relationship; Pathogenicity; Patients; Phenotype; Play; Process; Proliferating; Proteins; Relative (related person); Role; Saccharomyces cerevisiae; Site; Source; Spleen; Structure; Symbiosis; Systemic infection; Tail; Temperature; Testing; Transcript; Veins; Virulence; Work; Yeasts; base; feeding; fungus; in vitro Assay; in vivo; interest; mutant; novel; pathogen; programs; transcriptome sequencing

DESCRIPTION (provided by applicant): The yeast Candida albicans is a normal resident of the human digestive tract. It is also the most common fungal pathogen of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how C. albicans orchestrates its many interactions with the host. Our strategy is to approach aspects of commensalism and pathogenicity through dissection of the transcriptional circuitry that controls these processes. Our overarching goal is to understand how C. albicans is specialized to thrive and cause disease in many different environments of the host.

描述（由申请人提供）：白色念珠菌是人类消化道的正常居民。它也是人类最常见的真菌病原体，引起粘膜和全身感染，特别是在免疫受损的患者中。该提案旨在了解白色念珠菌如何协调其与宿主的多种相互作用。我们的策略是通过解剖控制这些过程的转录回路来研究共生性和致病性的各个方面。我们的首要目标是了解白色念珠菌如何在宿主的许多不同环境中专门繁殖并引起疾病。