Regulatory Circuits and Virulence in Candida albicans

白色念珠菌的调节回路和毒力

基本信息

批准号：
8589572
负责人：
ALEXANDER D JOHNSON
金额：
$ 71.34万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2016-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8589572
关键词：
Address Affect Antifungal Agents Bar Codes Biochemical Biological Candida albicans Carbon Carbon Dioxide Cells Collection Complex DNA DNA Binding DNA Binding Domain Data Deletion Mutation Disease Dissection Ectopic Expression Environment Environmental Risk Factor Fission Yeast Functional RNA Gastrointestinal tract structure Gene Targeting Genes Genetic Transcription Genome Goals Hand Heart Heritability Homologous Gene Human Immune In Vitro Individual Infection Injection of therapeutic agent Intercistronic Region Intestines Kidney Laboratories Leukocytes Life Link Liver Longitudinal Studies Modeling Molecular Molecular Target Monitor Mus Open Reading Frames Orthologous Gene Output Oxygen Partner in relationship Pathogenicity Patients Phenotype Play Process Proliferating Proteins Relative (related person)Role Saccharomyces cerevisiae Site Source Spleen Structure Symbiosis Systemic infection Tail Temperature Testing Transcript Veins Virulence Work Yeasts base feeding fungus in vitro Assay in vivo interest mutant novel pathogen programs transcriptome sequencing

Address Affect Antifungal Agents Bar Codes Biochemical Biological Candida albicans Carbon Carbon Dioxide Cells Collection Complex DNA DNA Binding DNA Binding Domain Data Deletion Mutation Disease Dissection Ectopic Expression Environment Environmental Risk Factor Fission Yeast Functional RNA Gastrointestinal tract structure Gene Targeting Genes Genetic Transcription Genome Goals Hand Heart Heritability Homologous Gene Human Immune In Vitro Individual Infection Injection of therapeutic agent Intercistronic Region Intestines Kidney Laboratories Leukocytes Life Link Liver Longitudinal Studies Modeling Molecular Molecular Target Monitor Mus Open Reading Frames Orthologous Gene Output Oxygen Partner in relationship Pathogenicity Patients Phenotype Play Process Proliferating Proteins Relative (related person)Role Saccharomyces cerevisiae Site Source Spleen Structure Symbiosis Systemic infection Tail Temperature Testing Transcript Veins Virulence Work Yeasts base feeding fungus in vitro Assay in vivo interest mutant novel pathogen programs transcriptome sequencing

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项目摘要

DESCRIPTION (provided by applicant): The yeast Candida albicans is a normal resident of the human digestive tract. It is also the most common fungal pathogen of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how C. albicans orchestrates its many interactions with the host. Our strategy is to approach aspects of commensalism and pathogenicity through dissection of the transcriptional circuitry that controls these processes. Our overarching goal is to understand how C. albicans is specialized to thrive and cause disease in many different environments of the host.

描述（由申请人提供）：白色念珠菌是人类消化道的普通居民。它也是人类最常见的真菌病原体，引起粘膜和全身感染，特别是在免疫受损的患者中。该提议试图了解白色念珠菌如何协调其与宿主的许多互动。我们的策略是通过解剖控制这些过程的转录电路来处理共生主义和致病性的各个方面。我们的总体目标是了解白色念珠菌如何在宿主的许多不同环境中壮成长和引起疾病。